Search Results - "Nesan, Dinushan"

Opening the black box of endocrine disruption of brain development: Lessons from the characterization of Bisphenol A by Nesan, Dinushan, Sewell, Laronna C., Kurrasch, Deborah M.

“…Bisphenol A (BPA) is among the best-studied endocrine disrupting chemicals, known to act via multiple steroid hormone receptors to mediate a myriad of cellular…”
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Gestational bisphenol A exposure alters energy homeostasis and adult hypothalamic neurogenesis in female mice by Feighan, Kira M., Nesan, Dinushan, Kurrasch, Deborah M.

“…Regulation of physiological homeostasis, including energy balance, is thought to be modified by low levels of adult neurogenesis in the hypothalamus. Hormones…”
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Cortisol regulates Na+ uptake in zebrafish, Danio rerio, larvae via the glucocorticoid receptor by Kumai, Yusuke, Nesan, Dinushan, Vijayan, Mathilakath M., Perry, Steve F.

“…► Cortisol stimulates Na+ uptake and ammonia excretion in zebrafish larvae through glucocorticoid receptor. ► The stimulation of Na+ uptake in larvae during…”
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Embryonic microglia influence developing hypothalamic glial populations by Marsters, Candace M, Nesan, Dinushan, Far, Rena, Klenin, Natalia, Pittman, Quentin J, Kurrasch, Deborah M

“…Although historically microglia were thought to be immature in the fetal brain, evidence of purposeful interactions between these immune cells and nearby…”
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The transcriptomics of glucocorticoid receptor signaling in developing zebrafish by Nesan, Dinushan, Vijayan, Mathilakath M

“…Cortisol is the primary corticosteroid in teleosts that is released in response to stressor activation of the hypothalamus-pituitary-interrenal axis. The…”
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Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis by Bashiri, Amir, Nesan, Dinushan, Tavallaee, Ghazaleh, Sue-Chue-Lam, Ian, Chien, Kevin, Maguire, Graham F., Naples, Mark, Zhang, Jing, Magomedova, Lilia, Adeli, Khosrow, Cummins, Carolyn L., Ng, Dominic S.

“…Non-alcoholic steatohepatitis (NASH), is the form of non-alcoholic fatty liver disease posing risk to progress into serious long term complications. Human and…”
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Gestational Exposure to Common Endocrine Disrupting Chemicals and Their Impact on Neurodevelopment and Behavior by Nesan, Dinushan, Kurrasch, Deborah M

“…Endocrine disrupting chemicals are common in our environment and act on hormone systems and signaling pathways to alter physiological homeostasis. Gestational…”
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Maternal Cortisol Mediates Hypothalamus-Pituitary-Interrenal Axis Development in Zebrafish by Nesan, Dinushan, Vijayan, Mathilakath M.

“…In zebrafish ( Danio rerio ), de novo synthesis of cortisol in response to stressor exposure commences only after hatch. Maternally deposited cortisol is…”
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Role of glucocorticoid in developmental programming: Evidence from zebrafish by Nesan, Dinushan, Vijayan, Mathilakath M

“…Highlights ► Ontogeny of corticosteroid stress axis is well conserved among vertebrates. ► Glucocorticoid receptor signaling is essential for zebrafish…”
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Embryo exposure to elevated cortisol level leads to cardiac performance dysfunction in zebrafish by Nesan, Dinushan, Vijayan, Mathilakath M.

“…► Exposure of zebrafish embryo to elevated cortisol level leads to heart deformities. ► Embryo cortisol exposure downregulates key genes involved in cardiac…”
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Genetic programs of the developing tuberal hypothalamus and potential mechanisms of their disruption by environmental factors by Nesan, Dinushan, Kurrasch, Deborah M.

“…The hypothalamus is a critical regulator of body homeostasis, influencing the autonomic nervous system and releasing trophic hormones to modulate the endocrine…”
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ODP269 Impacts of Gestational Bisphenol A Exposure on Adult Hypothalamic Neurogenesis by Feighan, Kira, Kurrasch, Deborah, Nesan, Dinushan

“…Abstract Regulation of physiological homeostasis by the hypothalamus is influenced by low basal levels of adult neurogenesis arising from proliferative cell…”
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Gestational low-dose BPA exposure impacts suprachiasmatic nucleus neurogenesis and circadian activity with transgenerational effects by Nesan, Dinushan, Feighan, Kira M, Antle, Michael C, Kurrasch, Deborah M

“…Critical physiological processes such as sleep and stress that underscore health are regulated by an intimate interplay between the endocrine and nervous…”
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An Efficient Method for Generating Murine Hypothalamic Neurospheres for the Study of Regional Neural Progenitor Biology by Nesan, Dinushan, Thornton, Hayley F, Sewell, Laronna C, Kurrasch, Deborah M

“…Abstract The hypothalamus is a key homeostatic brain region and the primary effector of neuroendocrine signaling. Recent studies show that early embryonic…”
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Lecithin:Cholesterol Acyltransferase (LCAT) Deficiency Promotes Differentiation of Satellite Cells to Brown Adipocytes in a Cholesterol-dependent Manner by Nesan, Dinushan, Tavallaee, Ghazaleh, Koh, Deborah, Bashiri, Amir, Abdin, Rawand, Ng, Dominic S.

“…Our laboratory previously reported that lecithin:cholesterol acyltransferase (LCAT) and LDL receptor double knock-out mice (Ldlr−/−xLcat−/− or DKO)…”
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Glucocorticoid Receptor Signaling Is Essential for Mesoderm Formation and Muscle Development in Zebrafish by Nesan, Dinushan, Kamkar, Maryam, Burrows, Jeffrey, Scott, Ian C, Marsden, Mungo, Vijayan, Mathilakath M

“…Glucocorticoid receptor (GR) signaling is thought to play a key role in embryogenesis, but its specific developmental effects remain unclear. Cortisol is the…”
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Recent development in targeting brown adipose tissues for the treatment of cardiometabolic diseases by Nesan, Dinushan, Ng, Dominic S

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Revising the high-density lipoprotein targeting strategies - Insights from human and preclinical studies by Nesan, Dinushan, Ng, Dominic S.

“…Abstract In recent years, the high-density lipoprotein (HDL) hypothesis has been challenged. Several completed randomized clinical trials continue to fall…”
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The Transcriptomics of Glucocorticoid Receptor Signaling in Developing Zebrafish: e80726 by Nesan, Dinushan, Vijayan, Mathilakath M

“…Cortisol is the primary corticosteroid in teleosts that is released in response to stressor activation of the hypothalamus-pituitary-interrenal axis. The…”
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