Search Results - "Nerurkar, Nandan L."

Villification: How the Gut Gets Its Villi by Shyer, Amy E., Tallinen, Tuomas, Nerurkar, Nandan L., Wei, Zhiyan, Gil, Eun Seok, Kaplan, David L., Tabin, Clifford J., Mahadevan, L.

“…The villi of the human and chick gut are formed in similar stepwise progressions, wherein the mesenchyme and attached epithelium first fold into longitudinal…”
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BMP signaling controls buckling forces to modulate looping morphogenesis of the gut by Nerurkar, Nandan L., Mahadevan, L., Tabin, Clifford J.

“…Looping of the initially straight embryonic gut tube is an essential aspect of intestinal morphogenesis, permitting proper placement of the lengthy small…”
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Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development by Huycke, Tyler R., Miller, Bess M., Gill, Hasreet K., Nerurkar, Nandan L., Sprinzak, David, Mahadevan, L., Tabin, Clifford J.

“…The gastrointestinal tract is enveloped by concentric and orthogonally aligned layers of smooth muscle; however, an understanding of the mechanisms by which…”
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Molecular control of macroscopic forces drives formation of the vertebrate hindgut by Nerurkar, Nandan L., Lee, ChangHee, Mahadevan, L., Tabin, Clifford J.

“…The embryonic gut tube is a cylindrical structure from which the respiratory and gastrointestinal tracts develop 1 . Although the early emergence of the…”
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Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus by Mauck, Robert L, Nerurkar, Nandan L, Baker, Brendon M, Sen, Sounok, Wible, Emily E, Elliott, Dawn M

“…Successful engineering of load-bearing tissues requires recapitulation of their complex mechanical functions. Given the intimate relationship between function…”
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Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity by Heo, Su-Jin, Driscoll, Tristan P, Thorpe, Stephen D, Nerurkar, Nandan L, Baker, Brendon M, Yang, Michael T, Chen, Christopher S, Lee, David A, Mauck, Robert L

“…Mesenchymal stem cell (MSC) differentiation is mediated by soluble and physical cues. In this study, we investigated differentiation-induced transformations in…”
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Degeneration and regeneration of the intervertebral disc: lessons from development by Smith, Lachlan J, Nerurkar, Nandan L, Choi, Kyung-Suk, Harfe, Brian D, Elliott, Dawn M

“…Degeneration of the intervertebral discs, a process characterized by a cascade of cellular, biochemical, structural and functional changes, is strongly…”
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Engineered disc-like angle-ply structures for intervertebral disc replacement by Nerurkar, Nandan L, Sen, Sounok, Huang, Alice H, Elliott, Dawn M, Mauck, Robert L

“…To develop a construction algorithm in which electrospun nanofibrous scaffolds are coupled with a biocompatible hydrogel to engineer a mesenchymal stem cell…”
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Homologous structure–function relationships between native fibrocartilage and tissue engineered from MSC-seeded nanofibrous scaffolds by Nerurkar, Nandan L, Han, Woojin, Mauck, Robert L, Elliott, Dawn M

“…Abstract Understanding the interplay of composition, organization and mechanical function in load-bearing tissues is a prerequisite in the successful…”
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Engineering on the straight and narrow: the mechanics of nanofibrous assemblies for fiber-reinforced tissue regeneration by Mauck, Robert L, Baker, Brendon M, Nerurkar, Nandan L, Burdick, Jason A, Li, Wan-Ju, Tuan, Rocky S, Elliott, Dawn M

“…Tissue engineering of fibrous tissues of the musculoskeletal system represents a considerable challenge because of the complex architecture and mechanical…”
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Editorial: Special issue on synthetic developmental biology by Nerurkar, Nandan L.

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Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries by Wagenseil, Jessica E, Nerurkar, Nandan L, Knutsen, Russell H, Okamoto, Ruth J, Li, Dean Y, Mecham, Robert P

“…Supravalvular aortic stenosis (SVAS) is associated with decreased elastin and altered arterial mechanics. Mice with a single deletion in the elastin gene…”
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A chemo-mechanical model of endoderm movements driving elongation of the amniote hindgut by Oikonomou, Panagiotis, Cirne, Helena C, Nerurkar, Nandan L

“…Although mechanical and biochemical descriptions of development are each essential, integration of upstream morphogenic cues with downstream tissue mechanics…”
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Morphogenetic adaptation of the looping embryonic heart to altered mechanical loads by Nerurkar, Nandan L., Ramasubramanian, Ashok, Taber, Larry A.

“…The biophysical mechanisms that drive and regulate cardiac looping are not well understood, but mechanical forces likely play a central role. Previous studies…”
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Mechanobiology of vertebrate gut morphogenesis by Durel, John F, Nerurkar, Nandan L

“…Approximately a century after D’Arcy Thompson’s On Growth and Form, there continues to be widespread interest in the biophysical and mathematical basis of…”
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Mechanical design criteria for intervertebral disc tissue engineering by Nerurkar, Nandan L, Elliott, Dawn M, Mauck, Robert L

“…Abstract Due to the inability of current clinical practices to restore function to degenerated intervertebral discs, the arena of disc tissue engineering has…”
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Evo-Devo Mechanobiology: The Missing Link by Loffet, Elise A, Durel, John F, Nerurkar, Nandan L

“…Synopsis While the modern framework of evolutionary development (evo-devo) has been decidedly genetic, historic analyses have also considered the importance of…”
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Elastic fibers define embryonic tissue stiffness to enable buckling morphogenesis of the small intestine by Loffet, Elise A, Durel, John F, Gao, Jenny, Kam, Richard, Lim, Hyunjee, Nerurkar, Nandan L

“…During embryonic development, tissues must possess precise material properties to ensure that cell-generated forces give rise to the stereotyped morphologies…”
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The developmental mechanics of divergent buckling patterns in the chick gut by Gill, Hasreet K, Yin, Sifan, Lawlor, John C, Huycke, Tyler R, Nerurkar, Nandan L, Tabin, Clifford J, Mahadevan, L

“…Tissue buckling is an increasingly appreciated mode of morphogenesis in the embryo, but it is often unclear how geometric and material parameters are…”
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Mechanics of oriented electrospun nanofibrous scaffolds for annulus fibrosus tissue engineering by Nerurkar, Nandan L., Elliott, Dawn M., Mauck, Robert L.

“…Engineering a functional replacement for the annulus fibrosus (AF) of the intervertebral disc is contingent upon recapitulation of AF structure, composition,…”
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