Search Results - "Nersting, J"

Cost-effective multiplexing before capture allows screening of 25 000 clinically relevant SNPs in childhood acute lymphoblastic leukemia by Wesolowska, A, Dalgaard, M D, Borst, L, Gautier, L, Bak, M, Weinhold, N, Nielsen, B F, Helt, L R, Audouze, K, Nersting, J, Tommerup, N, Brunak, S, Sicheritz-Ponten, T, Leffers, H, Schmiegelow, K, Gupta, R

“…Genetic variants, including single-nucleotide polymorphisms (SNPs), are key determiners of interindividual differences in treatment efficacy and toxicity in…”
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Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression by Mikkelsen, M, Sønder, S U, Nersting, J, Bendtzen, K

“…Spironolactone (SPIR) has been described to suppress accumulation of pro-inflammatory cytokines. Here, the suppression of TNF-alpha in lipopolysaccharide…”
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Maintenance therapy of childhood acute lymphoblastic leukemia revisited-Should drug doses be adjusted by white blood cell, neutrophil, or lymphocyte counts? by Schmiegelow, Kjeld, Nersting, Jacob, Nielsen, Stine Nygaard, Heyman, Mats, Wesenberg, Finn, Kristinsson, Jon, Vettenranta, Kim, Schrøeder, Henrik, Weinshilboum, Richard, Jensen, Katrine Lykke, Grell, Kathrine, Rosthoej, Susanne

“…Background 6‐Mercaptopurine (6MP) and methotrexate (MTX) based maintenance therapy is a critical phase of childhood acute lymphoblastic leukemia treatment…”
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Effects of germ line DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia by Tulstrup, M., Moriyama, T., Jiang, C., Grosjean, M., Nersting, J., Abrahamsson, Jonas, Grell, K., Hjalgrim, L. L., Jonsson, O. G., Kanerva, J., Lund, B., Nielsen, S. N., Nielsen, R. L., Quist-Paulsen, P., Pruunsild, K., Wolthers, B. O., Zhang, H., Gupta, R., Yang, J. J., Schmiegelow, K.

“…Methotrexate (MTX) during maintenance therapy is essential for curing acute lymphoblastic leukemia (ALL), but dosing strategies aiming at adequate treatment…”
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No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study by Nielsen, Stine Nygaard, Toksvang, Linea Natalie, Grell, Kathrine, Nersting, Jacob, Abrahamsson, Jonas, Lund, Bendik, Kanerva, Jukka, Jónsson, Ólafur Gísli, Vaitkeviciene, Goda, Pruunsild, Kaie, Appell, Malin Lindqvist, Hjalgrim, Lisa Lyngsie, Schmiegelow, Kjeld

“…Purpose 6-mercaptopurine(6MP)/methotrexate maintenance therapy is essential to reduce relapse of childhood acute lymphoblastic leukemia (ALL). Common germline…”
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Maintenance therapy and risk of osteonecrosis in children and young adults with acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study by Toksvang, Linea Natalie, Andrés-Jensen, Liv, Rank, Cecilie Utke, Niinimäki, Riitta, Nersting, Jacob, Nielsen, Stine Nygaard, Mogensen, Signe Sloth, Harila-Saari, Arja, Abrahamsson, Jonas, Joelsson, Joel, Overgaard, Ulrik Malthe, Quist-Paulsen, Petter, Griškevičius, Laimonas, Jónsson, Ólafur Gisli, Vaitkevičienė, Goda, Frandsen, Thomas Leth, Toft, Nina, Grell, Kathrine, Schmiegelow, Kjeld

“…Purpose Osteonecrosis is a burdensome treatment-related toxicity that is mostly diagnosed during or soon after 6-mercaptopurine (6MP)/methotrexate (MTX)…”
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Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study by Schmiegelow, Kjeld, Al-Modhwahi, Ibrahim, Andersen, Mette Klarskov, Behrendtz, Mikael, Forestier, Erik, Hasle, Henrik, Heyman, Mats, Kristinsson, Jon, Nersting, Jacob, Nygaard, Randi, Svendsen, Anne Louise, Vettenranta, Kim, Weinshilboum, Richard

“…Among 1614 children with acute lymphoblastic leukemia (ALL) treated with the Nordic Society for Paediatric Haematology and Oncology (NOPHO) ALL-92 protocol, 20…”
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NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia by Tulstrup, Morten, Grosjean, Marie, Nielsen, Stine Nygaard, Grell, Kathrine, Wolthers, Benjamin Ole, Wegener, Peder Skov, Jonsson, Olafur Gisli, Lund, Bendik, Harila-Saari, Arja, Abrahamsson, Jonas, Vaitkeviciene, Goda, Pruunsild, Kaie, Toft, Nina, Holm, Mette, Hulegårdh, Erik, Liestøl, Sigurd, Griskevicius, Laimonas, Punab, Mari, Wang, Jinhua, Carroll, William L., Zhang, Zeyu, Dalgaard, Marlene D., Gupta, Ramneek, Nersting, Jacob, Schmiegelow, Kjeld

“…The antileukaemic drug 6-mercaptopurine is converted into thioguanine nucleotides (TGN) and incorporated into DNA (DNA-TG), the active end metabolite. In a…”
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Hepatic sinusoidal obstruction syndrome during maintenance therapy of childhood acute lymphoblastic leukemia is associated with continuous asparaginase therapy and mercaptopurine metabolites by Toksvang, Linea Natalie, Pietri, Silvia, Nielsen, Stine N., Nersting, Jacob, Albertsen, Birgitte K., Wehner, Peder S., Rosthøj, Steen, Lähteenmäki, Päivi M., Nilsson, Daniel, Nystad, Tove A., Grell, Kathrine, Frandsen, Thomas L., Schmiegelow, Kjeld

“…Background Hepatic sinusoidal obstruction syndrome (SOS) during treatment of childhood acute lymphoblastic leukemia (ALL) has mainly been associated with…”
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Hepatotoxicity During Maintenance Therapy and Prognosis in Children With Acute Lymphoblastic Leukemia by Ebbesen, Maria S, Nygaard, Ulrikka, Rosthøj, Susanne, Sørensen, Ditte, Nersting, Jacob, Vettenranta, Kim, Wesenberg, Finn, Kristinsson, Jon, Harila-Saari, Arja, Schmiegelow, Kjeld

“…Hepatotoxicity is a known toxicity to treatment of childhood acute lymphoblastic leukemia. Hepatotoxicity occurs during maintenance therapy and is caused by…”
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Incorporation of 6-Thioguanine Nucleotides into DNA During Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia-The Influence of Thiopurine Methyltransferase Genotypes by Ebbesen, Maria S., Nersting, Jacob, Jacobsen, Jack H., Frandsen, Thomas L., Vettenranta, Kim, Abramsson, Jonas, Wesenberg, Finn, Schmiegelow, Kjeld

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Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: Influence on cure rates and risk of second cancer by Levinsen, Mette, Rotevatn, Elisabeth Ørskov, Rosthøj, Susanne, Nersting, Jacob, Abrahamsson, Jonas, Appell, Malin Lindqvist, Bergan, Stein, Bechensteen, Anne-Grete, Harila-Saari, Arja, Heyman, Mats, Jonsson, Olafur Gisli, Maxild, Jakob Bernhard Cohn, Niemi, Mikko, Söderhäll, Stefan, Schmiegelow, Kjeld

“…Background Previous studies have indicated that patients with thiopurine methyltransferase (TPMT) low activity (TPMTLA) have reduced risk of relapse but…”
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IgG Antibodies Cannot Explain Silent Inactivation in PEG-Asparaginase Treatment by Gottschalk Højfeldt, S, Harila-Saari, A, Lund, B, Abrahamsson, Jonas, Lähtenmäki, P, Henriksen, LT, Vaitkeviciene, G, Pruunsild, K, Jonsson, OG, Heyman, Mats, Schmiegelow, K, Albertsen, BK, Nersting, J

“…Background/Objectives: PEG-asparaginase represents a key element in the treatment of acute lymphoblastic leukemia (ALL), however allergic reactions and lack of…”
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Maturation of human dendritic cells by monocyte-conditioned medium is dependent upon trace amounts of lipopolysaccharide inducing tumour necrosis factor α by Nersting, Jacob, Svenson, Morten, Andersen, Vagn, Bendtzen, Klaus

“…We investigated the ability of monocyte-conditioned medium (MCM), generated by monocytes cultured on plastic-immobilised immunoglobulin, to stimulate…”
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Autoinflammatory disease: a new concept by Nersting, Jacob, Andersen, Vagn, Bendtzen, Klaus

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