Search Results - "Nerland, D E"

Covalent Binding of Acrylonitrile to Specific Rat Liver Glutathione S-Transferases in Vivo by Nerland, Donald E, Cai, Jian, Pierce, William M, Benz, Frederick W

“…Acrylonitrile (AN) is an industrial vinyl monomer that is acutely toxic. When administered to rats, AN covalently binds to tissue proteins in a dose-dependent…”
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Identification of N-acetyl-S-(2,5-dihydroxyphenyl)-L-cysteine as a urinary metabolite of benzene, phenol, and hydroquinone by Nerland, D E, Pierce, Jr, W M

“…The metabolite 2-(S-glutathionyl)hydroquinone is formed when a microsomal incubation mixture containing either benzene or phenol is supplemented with…”
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Inhibition of interferon gamma production by benzene and benzene metabolites by Cheung, S C, Nerland, D E, Sonnenfeld, G

“…We exposed spleen cells from female Swiss/Webster mice to benzene and benzene metabolites to determine the effects of such exposure on interferon gamma…”
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Acute acrylonitrile toxicity: studies on the mechanism of the antidotal effect of D- and L-cysteine and their N-acetyl derivatives in the rat by Benz, F W, Nerland, D E, Pierce, W M, Babiuk, C

“…Thiol-containing antidotes for acute acrylonitrile (AN) toxicity may exert their action by chemically reacting with AN, by replacing critical sulfhydryl groups…”
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Hematotoxicity and concentration-dependent conjugation of phenol in mice following inhalation exposure to benzene by Wells, M S, Nerland, D E

“…Benzene is metabolized to one or more hematotoxic species. Saturation of benzene metabolism could limit the production of toxic species. Saturation of phase II…”
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Type II interferon induction and passive transfer depress the murine cytochrome P-450 drug metabolism system by Sonnenfeld, G, Harned, C L, Thaniyavarn, S, Huff, T, Mandel, A D, Nerland, D E

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Kinetics of depression and recovery of murine hepatic cytochrome P-450 levels after treatment with the interferon inducer polyriboinosinic-polyribocytidylic acid by Crowe, D O, Reiners, Jr, J J, Nerland, D E, Sonnenfeld, G

“…In vivo treatment of randombred Swiss Webster mice with polyriboinosinic-polyribocytidylic acid (poly l X poly C) inhibited the induction of cytochrome P-450's…”
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Purification of mouse liver benzene dihydrodiol dehydrogenases by Bolcsak, L E, Nerland, D E

“…Multiple forms of cytosolic benzene dihydrodiol dehydrogenase (designated DD1, DD2, DD3, and DD4 according to order of elution from DEAE-cellulose column) were…”
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Gamma interferon induction depresses murine hepatic promutagen/procarcinogen activation by Reiners, Jr, J J, Crowe, D, McKeown, C, Nerland, D E, Sonnenfeld, G

“…In vivo induction of gamma interferon (IFN-gamma) by sensitization of mice with Mycobacterium bovis strain BCG and subsequent challenge with tuberculin…”
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Species, sex, and developmental differences in the O- and N-dealkylation of ethylmorphine by hepatic microsomes by Nerland, D E, Mannering, G J

“…3-O-[1'-14C]Ethylmorphine and ethylmorphine, respectively, were used to measure O- and N-dealkylase activities of hepatic microsomes. The well-known sex…”
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Qualitative and quantitative analyses of phenol, phenylglucuronide, and phenylsulfate in urine and plasma by gas chromatography/mass spectrometry by Pierce, Jr, W M, Nerland, D E

“…Phenol and related compounds are toxic agents to which humans are exposed. Analysis of phenolic compounds may be used as an index of exposure. In this report a…”
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Inhibition of erythropoiesis by benzene and benzene metabolites by Bolcsak, L E, Nerland, D E

“…Mice were injected sc with benzene or one of its metabolites, phenol, catechol, or hydroquinone. The ability of these compound to inhibit erythropoiesis was…”
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Induction of mouse liver glutathione S-transferase by ethanol by David, R M, Nerland, D E

“…The induction of hepatic glutathione S-transferase by ethanol was investigated in male Swiss-Webster mice using a liquid diet. After a 7-day feeding period,…”
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Inhibition of interferon-alpha/beta induction in L-929 cells by benzene and benzene metabolites by Cheung, S C, Nerland, D E, Sonnenfeld, G

“…Murine L-929 cells were treated with benzene or a series of benzene metabolites, washed and then interferon-alpha/beta was induced with…”
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Biological markers of acute acrylonitrile intoxication in rats as a function of dose and time by BENZ, F. W, NERLAND, D. E, CORBETT, D, LI, J

“…Three markers of acute acrylonitrile (AN) intoxication, namely, tissue glutathione (GSH), tissue cyanide (CN), and covalent binding to tissue protein, were…”
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Dose Dependence of Covalent Binding of Acrylonitrile to Tissue Protein and Globin in Rats by Benz, Frederick W., Nerland, Donald E., Li, Junyu, Corbett, Donna

“…The dose dependence of acrylonitrile (AN) covalent binding to tissue protein, following a single acute exposure over a 100-fold range in dose, was measured…”
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Use of linoleic acid hydroperoxide in the determination of absolute spectra of membrane-bound cytochrome P-450 by Nerland, D E, Iba, M M, Mannering, G J

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Quantitative analysis of 2-oxoglutarate in biological samples using liquid chromatography with electrochemical detection by Kaysinger, K K, Pierce, Jr, W M, Nerland, D E

“…This paper describes a technique for quantitative analysis of 2-oxoglutarate (alpha-ketoglutarate) in biological samples using liquid chromatography with…”
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Effects of cysteine isomers and derivatives on acute acrylonitrile toxicity by Nerland, D E, Benz, F W, Babiuk, C

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Measurement of effect of interferon on metabolism of diphenylhydantoin by Sonnenfeld, G, Nerland, D E

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