Search Results - "Neri, Fidencio"
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Global reference mapping of human transcription factor footprints
Published in Nature (London) (30-07-2020)“…Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been…”
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Index and biological spectrum of human DNase I hypersensitive sites
Published in Nature (London) (13-08-2020)“…DNase I hypersensitive sites (DHSs) are generic markers of regulatory DNA 1 – 5 and contain genetic variations associated with diseases and phenotypic traits 6…”
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Mapping and Dynamics of Regulatory DNA and Transcription Factor Networks in A. thaliana
Published in Cell reports (Cambridge) (25-09-2014)“…Our understanding of gene regulation in plants is constrained by our limited knowledge of plant cis-regulatory DNA and its dynamics. We mapped DNase I…”
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Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
Published in Science (American Association for the Advancement of Science) (07-09-2012)“…Genome-wide association studies have identified many noncoding variants associated with common diseases and traits. We show that these variants are…”
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5
Conservation of trans-acting circuitry during mammalian regulatory evolution
Published in Nature (London) (20-11-2014)“…The basic body plan and major physiological axes have been highly conserved during mammalian evolution, yet only a small fraction of the human genome sequence…”
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6
Mapping and Dynamics of Regulatory DNA in Maturing Arabidopsis thaliana Siliques
Published in Frontiers in plant science (14-11-2019)“…The genome is reprogrammed during development to produce diverse cell types, largely through altered expression and activity of key transcription factors. The…”
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Genome-scale mapping of DNase I sensitivity in vivo using tiling DNA microarrays
Published in Nature methods (01-07-2006)“…Localized accessibility of critical DNA sequences to the regulatory machinery is a key requirement for regulation of human genes. Here we describe a…”
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Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling
Published in Cell reports (Cambridge) (26-05-2020)“…The human genome encodes millions of regulatory elements, of which only a small fraction are active within a given cell type. Little is known about the global…”
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A comparative encyclopedia of DNA elements in the mouse genome
Published in Nature (London) (20-11-2014)“…The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two…”
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10
The accessible chromatin landscape of the human genome
Published in Nature (London) (06-09-2012)“…DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis -regulatory elements including…”
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Enhancing GTEx by bridging the gaps between genotype, gene expression, and disease
Published in Nature genetics (01-12-2017)“…Genetic variants have been associated with myriad molecular phenotypes that provide new insight into the range of mechanisms underlying genetic traits and…”
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Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution
Published in Science (American Association for the Advancement of Science) (21-11-2014)“…To study the evolutionary dynamics of regulatory DNA, we mapped >1.3 million deoxyribonuclease I–hypersensitive sites (DHSs) in 45 mouse cell and tissue types,…”
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13
Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling
Published in Cell reports (Cambridge) (23-06-2020)Get full text
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