Search Results - "Nepveu, Francoise"

Antimalarial activities of indolones and derivatives by Nepveu, Francoise, Najahi, Ennaji, Valentin, Alexis

“…The search for antimalarial compounds continues to be an area of intensive investigation in medicinal chemistry. This review presents the structural variations…”
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Interactions between Antimalarial Indolone-N-oxide Derivatives and Human Serum Albumin by Ibrahim, Nehal, Ibrahim, Hany, Kim, Sothea, Nallet, Jean-Pierre, Nepveu, Françoise

“…The binding affinity of human serum albumin (HSA) to three antimalarial indolone-N-oxide derivatives, INODs, was investigated under simulated physiological…”
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Interaction between Antimalarial 2‑Aryl‑3H‑indol-3-one Derivatives and Human Serum Albumin by Rakotoarivelo, Nambinina V, Perio, Pierre, Najahi, Ennaji, Nepveu, Françoise

“…Binding of drugs to plasma proteins, such as albumin, is a major factor which determines their pharmacokinetics and pharmacological effects. Therefore, the…”
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Molecular Pharmacology of NRH:Quinone Oxidoreductase 2: A Detoxifying Enzyme Acting as an Undercover Toxifying Enzyme by Janda, Elzbieta, Nepveu, Françoise, Calamini, Barbara, Ferry, Gilles, Boutin, Jean A.

“…N-ribosyldihydronicotinamide:quinone oxidoreductase 2 (NQO2/QR2, Enzyme Commission number 1.10.99.2) is a cytosolic enzyme, abundant in the liver and variably…”
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Melatonin facts: Lack of evidence that melatonin is a radical scavenger in living systems by Boutin, Jean A., Liberelle, Maxime, Yous, Saïd, Ferry, Gilles, Nepveu, Françoise

“…Melatonin is a small natural compound, so called a neuro‐hormone that is synthesized mainly in pineal gland in animals. Its main role is to master the clock of…”
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Artemisinin nanoformulation suitable for intravenous injection: Preparation, characterization and antimalarial activities by Ibrahim, Nehal, Ibrahim, Hany, Sabater, Alicia Moreno, Mazier, Dominique, Valentin, Alexis, Nepveu, Françoise

“…[Display omitted] More than 40 years after its discovery, artemisinin has become the most promising antimalarial agent. However, no intravenous formulation is…”
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The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production by Cassagnes, Laure-Estelle, Hervé, Vincent, Nepveu, Françoise, Hureau, Christelle, Faller, Peter, Collin, Fabrice

“…Copper‐amyloid‐β ROS production: Copper ions (red sphere, see picture) have been found to accumulate in amyloid‐β plaques and play a role in the generation of…”
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LUCS (Light-Up Cell System), a universal high throughput assay for homeostasis evaluation in live cells by Derick, Sylvain, Gironde, Camille, Perio, Pierre, Reybier, Karine, Nepveu, Françoise, Jauneau, Alain, Furger, Christophe

“…Observations of fluorescent cyanine dye behavior under illumination at 500 nm lead to a novel concept in cell biology allowing the development of a new live…”
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Effects of fermentation on the phytochemical composition and antioxidant properties of soy germ by Hubert, Jane, Berger, Monique, Nepveu, Françoise, Paul, François, Daydé, Jean

“…Soy germ is a remarkable source of bioactive phytochemicals offering an interesting alternative as starting ingredient for fermented food. This work aimed to…”
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Concentration and purification by magnetic separation of the erythrocytic stages of all human Plasmodium species by Ribaut, Clotilde, Berry, Antoine, Chevalley, Séverine, Reybier, Karine, Morlais, Isabelle, Parzy, Daniel, Nepveu, Françoise, Benoit-Vical, Françoise, Valentin, Alexis

“…Parasite concentration methods facilitate molecular, biochemical and immunological research on the erythrocytic stages of Plasmodium. In this paper, an…”
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Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2 by Cassagnes, Laure-Estelle, Chhour, Monivan, Pério, Pierre, Sudor, Jan, Gayon, Régis, Ferry, Gilles, Boutin, Jean A., Nepveu, Françoise, Reybier, Karine

“…There is increasing evidence that oxidative stress is involved in the etiology and pathogenesis of neurodegenerative disorders. Overproduction of reactive…”
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In cellulo monitoring of quinone reductase activity and reactive oxygen species production during the redox cycling of 1,2 and 1,4 quinones by Cassagnes, Laure-Estelle, Perio, Pierre, Ferry, Gilles, Moulharat, Natacha, Antoine, Mathias, Gayon, Régis, Boutin, Jean A., Nepveu, Françoise, Reybier, Karine

“…Quinones are highly reactive molecules that readily undergo either one- or two-electron reduction. One-electron reduction of quinones or their derivatives by…”
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Albumin-bound nanoparticles of practically water-insoluble antimalarial lead greatly enhance its efficacy by Ibrahim, Nehal, Ibrahim, Hany, Dormoi, Jerome, Briolant, Sébastien, Pradines, Bruno, Moreno, Alicia, Mazier, Dominique, Legrand, Philippe, Nepveu, Françoise

“…We recently showed that the indolone-N-oxides can be promising candidates for the treatment of chloroquine-resistant malaria. However, the in vivo assays have…”
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Targeting the redox metabolism of Plasmodium falciparum by Nepveu, Françoise, Turrini, Francesco

“…Targeting the redox metabolism of Plasmodium falciparum to create a fatal overload of oxidative stress is a route to explore the discovery of new antimalarial…”
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Antimalarial Properties of Dunnione Derivatives as NQO2 Substrates by Chhour, Monivan, Aubouy, Agnès, Bourgeade-Delmas, Sandra, Pério, Pierre, Ternet-Fontebasso, Hélène, Haidara, Mahamane, Ferry, Gilles, Nepveu, Françoise, Boutin, Jean A, Reybier, Karine

“…Dunnione, a natural product isolated from the leaves of (Gesneriaceae), acts as a substrate for quinone-reductases that may be associated with its antimalarial…”
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2-Aryl-3H-indol-3-ones: synthesis, electrochemical behaviour and antiplasmodial activities by Najahi, Ennaji, Valentin, Alexis, Fabre, Paul-Louis, Reybier, Karine, Nepveu, Françoise

“…The synthesis of indolone derivatives and their antiplasmodial activity in vitro against Plasmodium falciparum at the blood stage are described. The…”
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Insights into the redox cycle of human quinone reductase 2 by Reybier, Karine, Perio, Pierre, Ferry, Gilles, Bouajila, Jalloul, Delagrange, Philippe, Boutin, Jean A, Nepveu, Françoise

“…NRH:quinone oxidoreductase 2 (QR2) is a cytosolic enzyme that catalyzes the reduction of quinones, such as menadione and co-enzymes Q. With the aim of…”
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Association of NQO2 With UDP-Glucuronosyltransferases Reduces Menadione Toxicity in Neuroblastoma Cells by Chhour, Monivan, Perio, Pierre, Gayon, Regis, Ternet-Fontebasso, Hélène, Ferry, Gilles, Nepveu, Françoise, Boutin, Jean A., Sudor, Jan, Reybier, Karine

“…The balance between detoxification and toxicity is linked to enzymes of the drug metabolism Phase I (cytochrome P450 or oxidoreductases) and phase II…”
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Syk Kinase Inhibitors Synergize with Artemisinins by Enhancing Oxidative Stress in Plasmodium falciparum -Parasitized Erythrocytes by Tsamesidis, Ioannis, Reybier, Karine, Marchetti, Giuseppe, Pau, Maria Carmina, Virdis, Patrizia, Fozza, Claudio, Nepveu, Francoise, Low, Philip S, Turrini, Francesco Michelangelo, Pantaleo, Antonella

“…Although artemisinin-based combination therapies (ACTs) treat malaria effectively throughout most of the world, the recent expansion of ACT-resistant strains…”
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Microwave-assisted synthesis of chromeno[2,3-d] pyrimidinone derivatives by Chaker, Aida, Najahi, Ennaji, Nepveu, Françoise, Chanchoub, Fakher

“…New series of 10-anilino-9-alkyl-12-aryl-10,12-dihydro-11H-benzo[5,6] chromeno [2,3-d]pyrimidin-11-ones 5(a–e) and…”
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