Search Results - "Neptuno Rodriguez Lopez, Jose"

Targeting the methionine cycle for melanoma therapy with 3‐O‐(3,4,5‐trimethoxybenzoyl)‐(−)‐epicatechin by Sánchez‐del‐Campo, Luís, Rodríguez‐López, José Neptuno

“…The higher expression of methionine cycle genes in melanoma cells than in normal melanocytes may be related with increased protein synthesis and…”
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Catalysis and inactivation of tyrosinase in its action on hydroxyhydroquinone by del Mar Garcia‐Molina, Maria, Muñoz‐Muñoz, Jose Luis, Berna, Jose, García‐Ruiz, Pedro Antonio, Rodriguez‐Lopez, Jose Neptuno, Garcia‐Canovas, Francisco

“…Hydroxyhydroquinone (HHQ) was characterized kinetically as a tyrosinase substrate. A kinetic mechanism is proposed, in which HHQ is considered as a monophenol…”
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Generation of hydrogen peroxide in the melanin biosynthesis pathway by Munoz-Munoz, Jose Luis, García-Molina, Francisco, Varón, Ramón, Tudela, José, García-Cánovas, Francisco, Rodríguez-López, Jose Neptuno

“…The generation of H 2O 2 in the melanin biosynthesis pathway is of great importance because of its great cytotoxic capacity. However, there is controversy…”
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Mechanism of dihydrofolate reductase downregulation in melanoma by 3-O-(3,4,5-trimethoxybenzoyl)-(−)-epicatechin by Sánchez-del-Campo, Luís, Chazarra, Soledad, Montenegro, María F., Cabezas-Herrera, Juan, Rodríguez-López, José Neptuno

“…In our search to improve the stability and cellular absorption of tea polyphenols, we synthesized 3‐O‐(3,4,5‐trimethoxybenzoyl)‐(−)‐epicatechin (TMECG), which…”
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Ellagic acid: Characterization as substrate of polyphenol oxidase by Muñoz‐Muñoz, Jose Luis, Garcia‐Molina, Francisco, Garcia‐Molina, Maria, Tudela, Jose, García‐Cánovas, Francisco, Rodriguez‐Lopez, Jose Neptuno

“…Ellagic acid has been described as an inhibitor of tyrosinase or polyphenol oxidase and, therefore, of melanogenesis. In this work, we demonstrate that ellagic…”
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PRMT1-dependent methylation of BRCA1 contributes to the epigenetic defense of breast cancer cells against ionizing radiation by Montenegro, María F., González-Guerrero, Rebeca, Sánchez-del-Campo, Luis, Piñero-Madrona, Antonio, Cabezas-Herrera, Juan, Rodríguez-López, José Neptuno

“…The therapeutic effect of irradiation is thought to come from DNA damage that affects rapidly proliferating cancer cells; however, resistant cells rapidly…”
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Considerations on the action of polyphenoloxidase on 4-hydroxy-cinnamic acid. Molecular docking simulation by García Molina, Pablo, Antonio Teruel Puche, Jose, Luis Muñoz Muñoz, Jose, Neptuno Rodriguez Lopez, Jose, García Canovas, Francisco, García Molina, Francisco

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The Relationship between the IC50 Values and the Apparent Inhibition Constant in the Study of Inhibitors of Tyrosinase Diphenolase Activity Helps Confirm the Mechanism of Inhibition by Garcia-Molina, Pablo, Garcia-Molina, Francisco, Teruel-Puche, Jose Antonio, Rodriguez-Lopez, Jose Neptuno, Garcia-Canovas, Francisco, Muñoz-Muñoz, Jose Luis

“…Tyrosinase is the enzyme involved in melanization and is also responsible for the browning of fruits and vegetables. Control of its activity can be carried out…”
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Considerations about the inhibition of monophenolase and diphenolase activities of tyrosinase. Characterization of the inhibitor concentration which generates 50 % of inhibition, type and inhibition constants. A review by García Molina, Pablo, Saura-Sanmartin, Adrian, Berna, Jose, Teruel, Jose Antonio, Muñoz Muñoz, Jose Luis, Rodríguez López, Jose Neptuno, García Cánovas, Francisco, García Molina, Francisco

“…Tyrosinase is a copper oxidase enzyme which catalyzes the first two steps in the melanogenesis pathway, L-tyrosine to L-dopa conversion and, then, to…”
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Action of tyrosinase on alpha and beta-arbutin: A kinetic study by Garcia-Jimenez, Antonio, Teruel-Puche, Jose Antonio, Berna, Jose, Rodriguez-Lopez, José Neptuno, Tudela, Jose, Garcia-Canovas, Francisco

“…The known derivatives from hydroquinone, α and β-arbutin, are used as depigmenting agents. In this work, we demonstrate that the oxy form of tyrosinase…”
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Tyrosinase-Catalyzed Hydroxylation of 4‑Hexylresorcinol, an Antibrowning and Depigmenting Agent: A Kinetic Study by Ortiz-Ruiz, Carmen Vanessa, Berna, Jose, Rodriguez-Lopez, Jose Neptuno, Tomas, Virginia, Garcia-Canovas, Francisco

“…4-Hexylresorcinol (HR) is a compound used in the food and cosmetic industries as an antibrowning and lightening agent. Its use is mainly attributed to its…”
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Acriflavine, a Potent Inhibitor of HIF-1α, Disturbs Glucose Metabolism and Suppresses ATF4-Protective Pathways in Melanoma under Non-Hypoxic Conditions by Martí-Díaz, Román, Montenegro, María F, Cabezas-Herrera, Juan, Goding, Colin R, Rodríguez-López, José Neptuno, Sánchez-Del-Campo, Luis

“…Hypoxia-inducible factor (HIF)-1α is constitutively expressed in melanoma cells under normoxic conditions and its elevated expression correlates with the…”
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Prognostic value of the Breslow:diameter ratio in cutaneous melanoma by Piñero-Madrona, Antonio, Goméz-Ruiz, Alvaro Jesús, Ruiz-Merino, Guadalupe, Martínez-Barba, Enrique, Cerezuela-Fuentes, Pablo, Rodríguez-López, José Neptuno, Cabezas-Herrera, Juan

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Characterization of the action of tyrosinase on resorcinols by Garcia-Jimenez, Antonio, Teruel-Puche, Jose Antonio, Berna, José, Rodriguez-Lopez, José Neptuno, Tudela, Jose, Garcia-Ruiz, Pedro Antonio, Garcia-Canovas, Francisco

“…[Display omitted] •Resorcinol and some derivatives are alternative substrates of tyrosinase.•The o-quinone originated in each reaction isomerizes to a stable…”
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Cinnamate of inulin as a vehicle for delivery of colonic drugs by López-Molina, Dorotea, Chazarra, Soledad, How, Chee Wun, Pruidze, Nikolov, Navarro-Perán, Enma, García-Cánovas, Francisco, García-Ruiz, Pedro Antonio, Rojas-Melgarejo, Francisco, Rodríguez-López, José Neptuno

“…[Display omitted] Colon diseases are difficult to treat because oral administrated drugs are absorbed at the stomach and intestine levels and they do not reach…”
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Action of tyrosinase on caffeic acid and its n-nonyl ester. Catalysis and suicide inactivation by Garcia-Jimenez, Antonio, Teruel-Puche, Jose Antonio, Garcia-Ruiz, Pedro Antonio, Saura-Sanmartin, Adrian, Berna, Jose, Rodríguez-López, Jose Neptuno, Garcia-Canovas, Francisco

“…Different mechanisms for inhibiting tyrosinase can be designed to avoid postharvest quality losses of fruits and vegetables. The action of tyrosinase on…”
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Action of 2,2′,4,4′-tetrahydroxybenzophenone in the biosynthesis pathway of melanin by Garcia-Jimenez, Antonio, Teruel-Puche, Jose Antonio, Garcia-Ruiz, Pedro Antonio, Berna, Jose, Rodríguez-López, Jose Neptuno, Tudela, Jose, Garcia-Canovas, Francisco

“…2,2′,4,4′-tetrahydroxybenzophenone (Uvinul D50), a sunscreen used in cosmetics, has two effects in the melanin biosynthesis pathway. On the one hand, it acts a…”
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Considerations about the kinetic mechanism of tyrosinase in its action on monophenols: A review by García-Molina, Pablo, García-Molina, Francisco, Teruel-Puche, Jose Antonio, Rodríguez-López, José Neptuno, García-Cánovas, Francisco, Muñoz-Muñoz, José Luis

“…•Tyrosinase can hydroxylate a broad range of monophenols.•In Type A substrates, the o-quinone evolution generates o-diphenol in the medium.•In Types B, C and D…”
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Cancer-associated differences in acetylcholinesterase activity in bronchial aspirates from patients with lung cancer by Martínez-López de Castro, Ana, Nieto-Cerón, Susana, Aurelio, Pons-Castillo, Galbis-Martínez, Lilian, Latour-Pérez, Juan, Torres-Lanzas, Juan, Tovar-Zapata, Isabel, Martínez-Hernández, Pedro, Rodríguez-López, José Neptuno, Cabezas-Herrera, Juan

“…In non-neuronal contexts, ACh (acetylcholine) is thought to be involved in the regulation of vital cell functions, such as proliferation, differentiation,…”
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Purification and Kinetic Properties of Human Recombinant Dihydrofolate Reductase Produced in Bombyx mori Chrysalides by Chazarra, Soledad, Aznar-Cervantes, Salvador, Sánchez-del-Campo, Luis, Cabezas-Herrera, Juan, Xiaofeng, Wu, Cenis, José Luis, Rodríguez-López, José Neptuno

“…Recent reports describe the inhibition of human dihydrofolate reductase (hDHFR) by natural tea polyphenols. This finding could explain the epidemiologic data…”
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