Search Results - "Nepovimova, E."

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease by Hepnarova, V., Korabecny, J., Matouskova, L., Jost, P., Muckova, L., Hrabinova, M., Vykoukalova, N., Kerhartova, M., Kucera, T., Dolezal, R., Nepovimova, E., Spilovska, K., Mezeiova, E., Pham, N.L., Jun, D., Staud, F., Kaping, D., Kuca, K., Soukup, O.

“…Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed based on multi-target directed ligands (MTLDs) paradigm, synthesized and…”
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P.5.a.002 Therapeutic effect of novel 7-methoxytacrine-donepezil like hybrids on cognitive deficit in rats – a potentiality for Alzheimer's disease treatment by Kassa, J, Korabecny, J, Nepovimova, E, Misik, J

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Tetroxime: reactivation potency - in vitro and in silico study by Kuca, K, Korabecny, J, Dolezal, R, Nepovimova, E, Soukup, O, Gorecki, L, Musilek, K

“…Acetylcholinesterase (AChE) reactivators (oximes) are generally used as treatment in cases of nerve agent poisoning. There is no single oxime applicable in…”
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A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication by Nepovimova, E, Korabecny, J, Dolezal, R, Nguyen, T D, Jun, D, Soukup, O, Pasdiorova, M, Jost, P, Muckova, L, Malinak, D, Gorecki, L, Musilek, K, Kuca, Kamil

“…Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently…”
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Mycology-Nanotechnology Interface: Applications in Medicine and Cosmetology by Dhanjal, Daljeet Singh, Mehra, Parul, Bhardwaj, Sonali, Singh, Reena, Sharma, Parvarish, Nepovimova, Eugenie, Chopra, Chirag, Kuca, Kamil

“…In today's time, nanotechnology is being utilized to develop efficient products in the cosmetic and pharmaceutical industries. The application of…”
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Tacrine - tryptophan derivatives – novel agents against the Alzheimer’s disease by Soukup, O., Korabecny, J., Nepovimova, E., Karasova-Zdarova, J., Vales, K., Ricny, J., Jun, D., Kuca, K.

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Carbon dots in the center of the spotlight: A full evaluation of their synthesis and understanding of their fundamental properties and applications by de Conti, M.C.M.D., de Castro, A.A., Assis, L.C., Lima, N.M., Escriba, A., Nepovimova, E., Kuca, K., Ramalho, T.C., La Porta, F.A.

“…Due to the simplicity of fabricating the carbon dots (CQDs), which allows for scalability and cost-effectiveness, and their fascinating size-dependent physical…”
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Discovery of a 6‑Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities by Oleksak, Patrik, Rysanek, David, Vancurova, Marketa, Vasicova, Pavla, Urbancokova, Alexandra, Novak, Josef, Maurencova, Dominika, Kashmel, Pavel, Houserova, Jana, Mikyskova, Romana, Novotny, Ondrej, Reinis, Milan, Juda, Pavel, Hons, Miroslav, Kroupova, Jirina, Sedlak, David, Sulimenko, Tetyana, Draber, Pavel, Chlubnova, Marketa, Nepovimova, Eugenie, Kuca, Kamil, Lisa, Miroslav, Andrys, Rudolf, Kobrlova, Tereza, Soukup, Ondrej, Janousek, Jiri, Prchal, Lukas, Bartek, Jiri, Musilek, Kamil, Hodny, Zdenek

“…6-Nitrobenzo­[b]­thiophene 1,1-dioxide (Stattic) is a potent signal transducer and activator of the transcription 3 (STAT3) inhibitor developed originally for…”
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Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings by Kuca, Kamil, Karasova, Jana Zdarova, Soukup, Ondrej, Kassa, Jiri, Novotna, Eva, Sepsova, Vendula, Horova, Anna, Pejchal, Jaroslav, Hrabinova, Martina, Vodakova, Eva, Jun, Daniel, Nepovimova, Eugenie, Valis, Martin, Musilek, Kamil

“…Intoxication by nerve agents could be prevented by using small acetylcholinesterase inhibitors (eg, pyridostigmine) for potentially exposed personnel. However,…”
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A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxicationElectronic supplementary information (ESI) available: Experimental procedures and characterization of all compounds. See DOI: 10.1039/c6tx00130k by Nepovimova, E, Korabecny, J, Dolezal, R, Nguyen, T. D, Jun, D, Soukup, O, Pasdiorova, M, Jost, P, Muckova, L, Malinak, D, Gorecki, L, Musilek, K, Kuca, Kamil

“…Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently…”
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A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication† †Electronic supplementary information (ESI) available: Experimental procedures and characterization of all compounds. See DOI: 10.1039/c6tx00130k by Nepovimova, E., Korabecny, J., Dolezal, R., Nguyen, T. D., Jun, D., Soukup, O., Pasdiorova, M., Jost, P., Muckova, L., Malinak, D., Gorecki, L., Musilek, K., Kuca, Kamil

“…A novel hybrid able to protect organophosphate-inhibited AChE as well as to reactivate it. Chemical warfare agents constitute an increasing threat to both…”
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In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration by Hroudová, J., Fišar, Z., Korábečny, J., Nepovímová, E., Spilovská, K., Vašková, L., Mezeiová, E., Musílek, K., Kuča, K., Raboch, J.

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P.5.a.001 - In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration by Hroudová, J., Fišar, Z., Korábečny, J., Nepovímová, E., Spilovská, K., Vašková, L., Mezeiová, E., Musílek, K., Kuča, K., Raboch, J.

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