Search Results - "Nepogodiev, Sergey"

Complex pectin metabolism by gut bacteria reveals novel catalytic functions by Ndeh, Didier, Rogowski, Artur, Cartmell, Alan, Luis, Ana S., Baslé, Arnaud, Gray, Joseph, Venditto, Immacolata, Briggs, Jonathon, Zhang, Xiaoyang, Labourel, Aurore, Terrapon, Nicolas, Buffetto, Fanny, Nepogodiev, Sergey, Xiao, Yao, Field, Robert A., Zhu, Yanping, O’Neill, Malcolm A., Urbanowicz, Breeanna R., York, William S., Davies, Gideon J., Abbott, D. Wade, Ralet, Marie-Christine, Martens, Eric C., Henrissat, Bernard, Gilbert, Harry J.

“…The metabolism of carbohydrate polymers drives microbial diversity in the human gut microbiota. It is unclear, however, whether bacterial consortia or single…”
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Characterization of a nanoparticulate exopolysaccharide from Leuconostoc holzapfelii KM01 and its potential application in drug encapsulation by Charoenwongpaiboon, Thanapon, Wangpaiboon, Karan, Pichyangkura, Rath, Nepogodiev, Sergey A., Wonganan, Piyanuch, Mahalapbutr, Panupong, Field, Robert A.

“…Fermentation of Lactic Acid Bacteria (LAB) is considered to be a sustainable approach for polysaccharide production. Herein, exopolysaccharide (EPS)-producing…”
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Recent applications of the Cu(I)-catalysed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in carbohydrate chemistry by Dedola, Simone, Nepogodiev, Sergey A, Field, Robert A

“…This article surveys recent applications of Cu(I)-catalysed 1,3-dipolar cycloaddition of azides and alkynes in carbohydrate chemistry, highlighting…”
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Characterisation of insoluble α-1,3-/α-1,6 mixed linkage glucan produced in addition to soluble α-1,6-linked dextran by glucansucrase (DEX-N) from Leuconostoc citreum ABK-1 by Wangpaiboon, Karan, Waiyaseesang, Nisachon, Panpetch, Pawinee, Charoenwongpaiboon, Thanapon, Nepogodiev, Sergey A., Ekgasit, Sanong, Field, Robert A., Pichayangkura, Rath

“…Glucansucrases catalyse the formation of glucans from sucrose. The glucansucrase-encoding gene from Leuconostoc citreum ABK-1, dex-N, was successfully cloned…”
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Reply to: LsBOS utilizes oxalyl-CoA produced by LsAAE3 to synthesize β-ODAP in grass pea by Edwards, Anne, Jiang, Zhouqian, Nepogodiev, Sergey, Rejzek, Martin, Martin, Cathie, Emmrich, Peter M. F.

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Pan-genome analysis identifies intersecting roles for Pseudomonas specialized metabolites in potato pathogen inhibition by Pacheco-Moreno, Alba, Stefanato, Francesca L, Ford, Jonathan J, Trippel, Christine, Uszkoreit, Simon, Ferrafiat, Laura, Grenga, Lucia, Dickens, Ruth, Kelly, Nathan, Kingdon, Alexander Dh, Ambrosetti, Liana, Nepogodiev, Sergey A, Findlay, Kim C, Cheema, Jitender, Trick, Martin, Chandra, Govind, Tomalin, Graham, Malone, Jacob G, Truman, Andrew W

“…Agricultural soil harbors a diverse microbiome that can form beneficial relationships with plants, including the inhibition of plant pathogens. spp. are one of…”
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β-1,2-Oligomannan phosphorylase-mediated synthesis of potential oligosaccharide vaccine candidates by Ahmadipour, Sanaz, Winsbury, Rebecca, Köhler, Dominic, Pergolizzi, Giulia, Nepogodiev, Sergey A., Chessa, Simona, Dedola, Simone, Wang, Meng, Voglmeir, Josef, Field, Robert A.

“…β-(1,2)-Mannan antigens incorporated into vaccines candidates for immunization studies, showed that antibodies raised against β-(1,2)-mannotriose antigens can…”
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Lipopolysaccharide associated with β-2,6 fructan mediates TLR4-dependent immunomodulatory activity in vitro by Young, Ian D., Nepogodiev, Sergey A., Black, Ian M., Le Gall, Gwenaelle, Wittmann, Alexandra, Latousakis, Dimitrios, Visnapuu, Triinu, Azadi, Parastoo, Field, Robert A., Juge, Nathalie, Kawasaki, Norihito

“…Levan, a β-2,6 fructofuranose polymer produced by microbial species, has been reported for its immunomodulatory properties via interaction with toll-like…”
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Chemoenzymatic Synthesis of Fluorinated Cellodextrins Identifies a New Allomorph for Cellulose‐Like Materials by Andrade, Peterson, Muñoz‐García, Juan C., Pergolizzi, Giulia, Gabrielli, Valeria, Nepogodiev, Sergey A., Iuga, Dinu, Fábián, László, Nigmatullin, Rinat, Johns, Marcus A., Harniman, Robert, Eichhorn, Stephen J., Angulo, Jesús, Khimyak, Yaroslav Z., Field, Robert A.

“…Understanding the fine details of the self‐assembly of building blocks into complex hierarchical structures represents a major challenge en route to the design…”
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Structural and functional analyses of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II by Labourel, Aurore, Baslé, Arnaud, Munoz-Munoz, Jose, Ndeh, Didier, Booth, Simon, Nepogodiev, Sergey A., Field, Robert A., Cartmell, Alan

“…The metabolism of carbohydrate polymers drives microbial diversity in the human gut microbiome. The selection pressures in this environment have spurred the…”
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Biochemical Basis of Xylooligosaccharide Utilisation by Gut Bacteria by Singh, Ravindra Pal, Bhaiyya, Raja, Thakur, Raksha, Niharika, Jayashree, Singh, Chandrajeet, Latousakis, Dimitrios, Saalbach, Gerhard, Nepogodiev, Sergey A, Singh, Praveen, Sharma, Sukesh Chander, Sengupta, Shantanu, Juge, Nathalie, Field, Robert A

“…Xylan is one of the major structural components of the plant cell wall. Xylan present in the human diet reaches the large intestine undigested and becomes a…”
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Biomolecular Characterization of the Levansucrase of Erwinia amylovora, a Promising Biocatalyst for the Synthesis of Fructooligosaccharides by Caputi, Lorenzo, Nepogodiev, Sergey A, Malnoy, Mickael, Rejzek, Martin, Field, Robert A, Benini, Stefano

“…Erwinia amylovora is a plant pathogen that affects Rosaceae, such as apple and pear. In E. amylovora the fructans, produced by the action of a levansucrase…”
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Cellodextrin phosphorylase from Ruminiclostridium thermocellum: X-ray crystal structure and substrate specificity analysis by O'Neill, Ellis C., Pergolizzi, Giulia, Stevenson, Clare E.M., Lawson, David M., Nepogodiev, Sergey A., Field, Robert A.

“…The GH94 glycoside hydrolase cellodextrin phosphorylase (CDP, EC 2.4.1.49) produces cellodextrin oligomers from short β-1→4-glucans and α-D-glucose…”
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Ascertaining the biochemical function of an essential pectin methylesterase in the gut microbe Bacteroides thetaiotaomicron by Duan, Cheng-Jie, Baslé, Arnaud, Liberato, Marcelo Visona, Gray, Joseph, Nepogodiev, Sergey A., Field, Robert A., Juge, Nathalie, Ndeh, Didier

“…Pectins are a major dietary nutrient source for the human gut microbiota. The prominent gut microbe Bacteroides thetaiotaomicron was recently shown to encode…”
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Heterologous Expression of the Formicamycin Biosynthetic Gene Cluster Unveils Glycosylated Fasamycin Congeners by McDonald, Hannah P., Alford, Abigail, Devine, Rebecca, Hems, Edward S., Nepogodiev, Sergey A., Arnold, Corinne J., Rejzek, Martin, Stanley-Smith, Anna, Holmes, Neil A., Hutchings, Matthew I., Wilkinson, Barrie

“…Formicamycins and their biosynthetic intermediates the fasamycins are polyketide antibiotics produced by Streptomyces formicae KY5 from a pathway encoded by…”
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Discovery of an RmlC/D fusion protein in the microalga Prymnesium parvum and its implications for NDP-β-l-rhamnose biosynthesis in microalgae by Wagstaff, Ben A., Rejzek, Martin, Kuhaudomlarp, Sakonwan, Hill, Lionel, Mascia, Ilaria, Nepogodiev, Sergey A., Dorfmueller, Helge C., Field, Robert A.

“…The 6-deoxy sugar l-rhamnose (l-Rha) is found widely in plant and microbial polysaccharides and natural products. The importance of this and related compounds…”
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Spinning sugars in antigen biosynthesis: characterization of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases by Cross, Alice R., Roy, Sumita, Vivoli Vega, Mirella, Rejzek, Martin, Nepogodiev, Sergey A., Cliff, Matthew, Salmon, Debbie, Isupov, Michail N., Field, Robert A., Prior, Joann L., Harmer, Nicholas J.

“…The sugars streptose and dihydrohydroxystreptose (DHHS) are unique to the bacteria Streptomyces griseus and Coxiella burnetii, respectively. Streptose forms…”
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Synthesis of glyceryl glycosides related to A-type prymnesin toxins by Hems, Edward S., Nepogodiev, Sergey A., Rejzek, Martin, Field, Robert A.

“…A suite of glycosylated glycerol derivatives representing various fragments of the glycosylated ichthyotoxins called prymnesins were chemically synthesised…”
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Differential Toll-Like Receptor-Signalling of Burkholderia pseudomallei Lipopolysaccharide in Murine and Human Models by Weehuizen, Tassili A F, Prior, Joann L, van der Vaart, Thomas W, Ngugi, Sarah A, Nepogodiev, Sergey A, Field, Robert A, Kager, Liesbeth M, van 't Veer, Cornelis, de Vos, Alex F, Wiersinga, W Joost

“…The Gram-negative bacterium Burkholderia pseudomallei causes melioidosis and is a CDC category B bioterrorism agent. Toll-like receptor (TLR)-2 impairs host…”
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The impact of aminopyrene trisulfonate (APTS) label in acceptor glycan substrates for profiling plant pectin β-galactosyltransferase activities by Goetz, Stephan, Rejzek, Martin, Nepogodiev, Sergey A., Field, Robert A.

“…Aminopyrene trisulfonate (APTS)-labelled disaccharides are demonstrated to serve as readily accessible acceptor substrates for galactosyltransferase activities…”
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