Search Results - "Neoptolemos, John P."

Therapeutic developments in pancreatic cancer: current and future perspectives by Neoptolemos, John P., Kleeff, Jörg, Michl, Patrick, Costello, Eithne, Greenhalf, William, Palmer, Daniel H.

“…The overall 5-year survival for pancreatic cancer has changed little over the past few decades, and pancreatic cancer is predicted to be the second leading…”
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Understanding Metastasis in Pancreatic Cancer: A Call for New Clinical Approaches by Tuveson, David A., Neoptolemos, John P.

“…Although metastasis is a major cause of morbidity and mortality in patients with pancreatic cancer, the requisite events are currently unknown. In this issue…”
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Prognostic Factors of Survival After Neoadjuvant Treatment and Resection for Initially Unresectable Pancreatic Cancer by Klaiber, Ulla, Schnaidt, Eva S., Hinz, Ulf, Gaida, Matthias M., Heger, Ulrike, Hank, Thomas, Strobel, Oliver, Neoptolemos, John P., Mihaljevic, André L., Büchler, Markus W., Hackert, Thilo

“…MINIWe analyzed prognostic factors after neoadjuvant therapy and resection in 280 patients with initially unresectable pancreatic cancer—the largest…”
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The Impact of Positive Resection Margins on Survival and Recurrence Following Resection and Adjuvant Chemotherapy for Pancreatic Ductal Adenocarcinoma by Ghaneh, Paula, Kleeff, Jorg, Halloran, Christopher M, Raraty, Michael, Jackson, Richard, Melling, James, Jones, Owain, Palmer, Daniel H, Cox, Trevor F, Smith, Chloe J, O’Reilly, Derek A, Izbicki, Jakob R, Scarfe, Andrew G, Valle, Juan W, McDonald, Alexander C, Carter, Ross, Tebbutt, Niall C, Goldstein, David, Padbury, Robert, Shannon, Jennifer, Dervenis, Christos, Glimelius, Bengt, Deakin, Mark, Anthoney, Alan, Lerch, Markus M, Mayerle, Julia, Oláh, Attila, Rawcliffe, Charlotte L, Campbell, Fiona, Strobel, Oliver, Büchler, Markus W, Neoptolemos, John P

“…OBJECTIVE AND BACKGROUND:Local and distant disease recurrence are frequently observed following pancreatic cancer resection, but an improved understanding of…”
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Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma by Smith, Richard A., M.R.C.S, Bosonnet, Lorraine, P.G.Dip, Raraty, Michael, F.R.C.S, Sutton, Robert, F.R.C.S, Neoptolemos, John P., F.R.C.S, Campbell, Fiona, F.R.C.Path, Ghaneh, Paula, F.R.C.S

“…Abstract Background The objective of this study was to investigate whether the preoperative platelet-lymphocyte (P/L) ratio represents a significant prognostic…”
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Postpancreatectomy hemorrhage (PPH)–An International Study Group of Pancreatic Surgery (ISGPS) definition by Wente, Moritz N., MD, Veit, Johannes A., MD, Bassi, Claudio, MD, Dervenis, Christos, MD, Fingerhut, Abe, MD, Gouma, Dirk J., MD, Izbicki, Jakob R., MD, Neoptolemos, John P., MD, Padbury, Robert T., MD, Sarr, Michael G., MD, Yeo, Charles J., MD, Büchler, Markus W., MD

“…Background Postoperative hemorrhage is one of the most severe complications after pancreatic surgery. Due to the lack of an internationally accepted, universal…”
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Delayed gastric emptying (DGE) after pancreatic surgery: A suggested definition by the International Study Group of Pancreatic Surgery (ISGPS) by Wente, Moritz N., MD, Bassi, Claudio, MD, Dervenis, Christos, MD, Fingerhut, Abe, MD, Gouma, Dirk J., MD, Izbicki, Jakob R., MD, Neoptolemos, John P., MD, Padbury, Robert T., MD, Sarr, Michael G., MD, Traverso, L. William, MD, Yeo, Charles J., MD, Büchler, Markus W., MD

“…Background Delayed gastric emptying (DGE) is one of the most common complications after pancreatic resection. In the literature, the reported incidence of DGE…”
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Severe acute pancreatitis: surgical indications and treatment by Heckler, Max, Hackert, Thilo, Hu, Kai, Halloran, Cristopher M., Büchler, Markus W., Neoptolemos, John P.

“…Background Acute pancreatitis (AP) is defined as an acute inflammatory attack of the pancreas of sudden onset. Around 25% of patients have either moderately…”
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Phase III Randomized Comparison of Gemcitabine Versus Gemcitabine Plus Capecitabine in Patients With Advanced Pancreatic Cancer by CUNNINGHAM, David, CHAU, Ian, FALK, Stephen, CRELLIN, Adrian, ADAB, Fawzi, THOMPSON, Joyce, LEONARD, Pauline, OSTROWSKI, Joe, EATOCH, Martin, SCHEITHAUER, Werner, HERRMANN, Richard, NEOPTOLEMOS, John P, STOCKEN, Deborah D, VALLE, Juan W, SMITH, David, STEWARD, William, HARPER, Peter G, DUNN, Janet, TUDUR-SMITH, Catrin, WEST, Julia

“…Both gemcitabine (GEM) and fluoropyrimidines are valuable treatment for advanced pancreatic cancer. This open-label study was designed to compare the overall…”
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Optimal Duration and Timing of Adjuvant Chemotherapy After Definitive Surgery for Ductal Adenocarcinoma of the Pancreas: Ongoing Lessons From the ESPAC-3 Study by VALLE, Juan W, PALMER, Daniel, O'REILLY, Derek, GOLDSTEIN, David, ROBINSON, Bridget A, KARAPETIS, Christos, SCARFE, Andrew, LACAINE, Francois, SAND, Juhani, IZBICKI, Jakob R, MAYERLE, Julia, DERVENIS, Christos, JACKSON, Richard, OLAH, Attila, BUTTURINI, Giovanni, LIND, Pehr A, MIDDLETON, Mark R, ANTHONEY, Alan, SUMPTER, Kate, CARTER, Ross, BÜCHLER, Markus W, COX, Trevor, NEOPTOLEMOS, John P, GHANEH, Paula, RAWCLIFFE, Charlotte L, BASSI, Claudio, STOCKEN, Deborah D, CUNNINGHAM, David

“…Adjuvant chemotherapy improves patient survival rates after resection for pancreatic adenocarcinoma, but the optimal duration and time to initiate chemotherapy…”
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Circulating microRNAs as potential markers of human drug‐induced liver injury by Starkey Lewis, Philip J., Dear, James, Platt, Vivien, Simpson, Kenneth J., Craig, Darren G.N., Antoine, Daniel J., French, Neil S., Dhaun, Neeraj, Webb, David J., Costello, Eithne M., Neoptolemos, John P., Moggs, Jonathan, Goldring, Chris E., Park, B. Kevin

“…New biomarkers of liver injury are required in the clinic and in preclinical pharmaceutical evaluation. Previous studies demonstrate that two liver‐enriched…”
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Meta-Analyses of Chemotherapy for Locally Advanced and Metastatic Pancreatic Cancer by SULTANA, Asma, SMITH, Catrin Tudur, CUNNINGHAM, David, STARLING, Naureen, NEOPTOLEMOS, John P, GHANEH, Paula

“…There are a large number of randomized controlled trials involving chemotherapy in the management of advanced pancreatic cancer. Several chemotherapeutic…”
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Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial by GREENHALF, William, GHANEH, Paula, MOORE, Malcolm J, VALLE, Juan W, MCDONALD, Alexander C, CARTER, Ross, TEBBUTT, Niall C, GOLDSTEIN, David, SHANNON, Jennifer, DERVENIS, Christos, GLIMELIUS, Bengt, DEAKIN, Mark, NEOPTOLEMOS, John P, CHARNLEY, Richard M, LACAINE, François, SCARFE, Andrew G, MIDDLETON, Mark R, ANTHONEY, Alan, HALLORAN, Christopher M, MAYERLE, Julia, OLAH, Attila, JACKSON, Richard, RAWCLIFFE, Charlotte L, PALMER, Daniel H, SCARPA, Aldo, BASSI, Claudio, BÜCHLER, Markus W, COX, Trevor F, LAMB, Richard F, GARNER, Elizabeth, CAMPBELL, Fiona, MACKEY, John R, COSTELLO, Eithne

“…Human equilibrative nucleoside transporter 1 (hENT1) levels in pancreatic adenocarcinoma may predict survival in patients who receive adjuvant gemcitabine…”
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Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice by Jandaghi, Pouria, Najafabadi, Hamed S, Bauer, Andrea S, Papadakis, Andreas I, Fassan, Matteo, Hall, Anita, Monast, Anie, von Knebel Doeberitz, Magnus, Neoptolemos, John P, Costello, Eithne, Greenhalf, William, Scarpa, Aldo, Sipos, Bence, Auld, Daniel, Lathrop, Mark, Park, Morag, Büchler, Markus W, Strobel, Oliver, Hackert, Thilo, Giese, Nathalia A, Zogopoulos, George, Sangwan, Veena, Huang, Sidong, Riazalhosseini, Yasser, Hoheisel, Jörg D

“…Background & Aims Incidence of and mortality from pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, are almost equivalent, so…”
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Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy by Lister, Adam, Nedjadi, Taoufik, Kitteringham, Neil R, Campbell, Fiona, Costello, Eithne, Lloyd, Bryony, Copple, Ian M, Williams, Samantha, Owen, Andrew, Neoptolemos, John P, Goldring, Chris E, Park, B Kevin

“…Nrf2 is a key transcriptional regulator of a battery of genes that facilitate phase II/III drug metabolism and defence against oxidative stress. Nrf2 is…”
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Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial by Diener, Markus K, MD, Seiler, Christoph M, Prof, Rossion, Inga, MD, Kleeff, Jörg, Prof, Glanemann, Matthias, MD, Butturini, Giovanni, MD, Tomazic, Ales, MD, Bruns, Christiane J, Prof, Busch, Olivier RC, Prof, Farkas, Stefan, MD, Belyaev, Orlin, MD, Neoptolemos, John P, Prof, Halloran, Christopher, MD, Keck, Tobias, Prof, Niedergethmann, Marco, Prof, Gellert, Klaus, Prof, Witzigmann, Helmut, Prof, Kollmar, Otto, MD, Langer, Peter, Prof, Steger, Ulrich, MD, Neudecker, Jens, MD, Berrevoet, Frederik, MD, Ganzera, Silke, MD, Heiss, Markus M, Prof, Luntz, Steffen P, MD, Bruckner, Thomas, PhD, Kieser, Meinhard, Prof, Büchler, Markus W, Prof

“…Summary Background The ideal closure technique of the pancreas after distal pancreatectomy is unknown. We postulated that standardised closure with a stapler…”
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S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes by Nedjadi, Taoufik, Evans, Anthony, Sheikh, Adnan, Barerra, Lawrence, Al-Ghamdi, Suliman, Oldfield, Lucy, Greenhalf, W, Neoptolemos, John P, Costello, Eithne

“…The secretion of soluble factors enables communication between tumour cells and the surrounding microenvironment and plays an important role in oncogenesis…”
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Independent Validation and Assay Standardization of Improved Metabolic Biomarker Signature to Differentiate Pancreatic Ductal Adenocarcinoma From Chronic Pancreatitis by Mahajan, Ujjwal M., Oehrle, Bettina, Sirtl, Simon, Alnatsha, Ahmed, Goni, Elisabetta, Regel, Ivonne, Beyer, Georg, Vornhülz, Marlies, Vielhauer, Jakob, Chromik, Ansgar, Bahra, Markus, Klein, Fritz, Uhl, Waldemar, Fahlbusch, Tim, Distler, Marius, Weitz, Jürgen, Grützmann, Robert, Pilarsky, Christian, Weiss, Frank Ulrich, Adam, M. Gordian, Neoptolemos, John P., Kalthoff, Holger, Rad, Roland, Christiansen, Nicole, Bethan, Bianca, Kamlage, Beate, Lerch, Markus M., Mayerle, Julia

“…Pancreatic ductal adenocarcinoma cancer (PDAC) is a highly lethal malignancy requiring efficient detection when the primary tumor is still resectable. We…”
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Guidelines for the Diagnostic Cross Sectional Imaging and Severity Scoring of Chronic Pancreatitis by Frøkjær, Jens Brøndum, Akisik, Fatih, Farooq, Ammad, Akpinar, Burcu, Dasyam, Anil, Drewes, Asbjørn Mohr, Haldorsen, Ingfrid S., Morana, Giovanni, Neoptolemos, John P., Olesen, Søren Schou, Petrone, Maria Chiara, Sheel, Andrea, Shimosoegawa, Tooru, Whitcomb, David C.

“…The paper presents the international guidelines for imaging evaluation of chronic pancreatitis. The following consensus was obtained: Computed tomography (CT)…”
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Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells by Booth, David M, Murphy, John A, Mukherjee, Rajarshi, Awais, Muhammad, Neoptolemos, John P, Gerasimenko, Oleg V, Tepikin, Alexei V, Petersen, Ole H, Sutton, Robert, Criddle, David N

“…Background & Aims Oxidative stress is implicated in the pathogenesis of pancreatitis, but clinical trials of antioxidants have produced conflicting results. We…”
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