Search Results - "Neoptolemos, JP"

Adjuvant therapy in pancreatic cancer: historical and current perspectives by Neoptolemos, J. P., Cunningham, D., Friess, H., Bassi, C., Stocken, D. D., Tait, D. M., Dunn, J. A., Dervenis, C., Lacaine, F., Hickey, H., Raraty, M. G. T., Ghaneh, P., Büchler, M. W.

“…The results from pancreatic ductal adenocarcinoma appear to be improving with increased resection rates and reduced postoperative mortality reported by…”
Get full text

PALB2 mutations in European familial pancreatic cancer families by Slater, EP, Langer, P, Niemczyk, E, Strauch, K, Butler, J, Habbe, N, Neoptolemos, JP, Greenhalf, W, Bartsch, DK

“…Slater EP, Langer P, Niemczyk E, Strauch K, Butler J, Habbe N, Neoptolemos JP, Greenhalf W, Bartsch DK. PALB2 mutations in European pancreatic cancer families…”
Get full text

Surgical treatment of pancreatic fistula by Alexakis, N, Sutton, R, Neoptolemos, J P

“…Pancreatic fistula remains a significant problem in pancreatic disease, trauma and surgery. Whilst improved diagnostic and treatment techniques, including…”
Get more information

Pancreatic stents with diclofenac reduce the incidence of post ERCP pancreatitis in patients undergoing molecular screening of pancreatic juice for pancreatic cancer by Nicholson, J.A, Butler, J, Harrison, S, Greenhalf, W, Sutton, R, Halloran, C, Raraty, M, Ghaneh, P, Sarkar, S, Smart, H.L, Evans, J.C, Neoptolemos, J.P, Lombard, M

“…Methods: Prospective observational study of 49 consecutive high risk cancer patients with a normal pancreas undergoing molecular screening using ERCP for PJ…”
Get full text

Pancreatic stents with diclofenac reduce the incidence of post ERCP pancreatitis in patients undergoing molecular screening of pancreatic juice for pancreatic cancer by Nicholson, J.A, Butler, J, Harrison, S, Greenhalf, W, Sutton, R, Halloran, C, Raraty, M, Ghaneh, P, Sarkar, S, Smart, H.L, Evans, J.C, Neoptolemos, J.P, Lombard, M

“…Stent placement and diclofenac administration has shown a significant reduction in the rate of PEP among individuals being screened for pancreatic cancer…”
Get full text

Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study by Neoptolemos, JP, Kemppainen, EA, Mayer, JM, Fitzpatrick, JM, Raraty, MGT, Slavin, J, Beger, H-G, Hietaranta, AJ, Puolakkainen, PA

“…There is a pressing clinical requirement for an early simple test of severity in acute pancreatitis. We investigated the use of an assay of trypsinogen…”
Get full text

Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones by Neoptolemos, J P, Carr-Locke, D L, London, N J, Bailey, I A, James, D, Fossard, D P

“…121 patients with acute pancreatitis thought to be due to gallstones were randomised to treatment with urgent endoscopic retrograde cholangiopancreatography…”
Get more information

European evidence-based guidelines on pancreatic cystic neoplasms

“…Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group…”
Get more information

Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial by Neoptolemos, John P, Prof, Palmer, Daniel H, Prof, Ghaneh, Paula, Prof, Psarelli, Eftychia E, MSc, Valle, Juan W, MD, Halloran, Christopher M, MD, Faluyi, Olusola, MD, O'Reilly, Derek A, MD, Cunningham, David, Prof, Wadsley, Jonathan, Prof, Darby, Suzanne, MD, Meyer, Tim, Prof, Gillmore, Roopinder, MD, Anthoney, Alan, MD, Lind, Pehr, MD, Glimelius, Bengt, MD, Falk, Stephen, MD, Izbicki, Jakob R, Prof, Middleton, Gary William, MD, Cummins, Sebastian, MD, Ross, Paul J, MD, Wasan, Harpreet, MD, McDonald, Alec, MD, Crosby, Tom, MD, Ma, Yuk Ting, MD, Patel, Kinnari, MD, Sherriff, David, FRCR, Soomal, Rubin, MD, Borg, David, MD, Sothi, Sharmila, MD, Hammel, Pascal, Prof, Hackert, Thilo, MD, Jackson, Richard, PhD, Büchler, Markus W, Prof

“…Summary Background The ESPAC-3 trial showed that adjuvant gemcitabine is the standard of care based on similar survival to and less toxicity than adjuvant…”
Get full text

Surgical and medical therapy for pancreatic carcinoma by Magee, Conor J., Ghaneh, Paula, Neoptolemos, John P.

“…Progress on the treatment of pancreatic ductal adenocarcinoma has involved advances in medical and surgical care with important contributions from disciplines…”
Get full text

Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Secondary Analysis of the ESPAC-4 Randomized Adjuvant Chemotherapy Trial by Jones, Robert P, Psarelli, Eftychia-Eirini, Jackson, Richard, Ghaneh, Paula, Halloran, Christopher M, Palmer, Daniel H, Campbell, Fiona, Valle, Juan W, Faluyi, Olusola, O'Reilly, Derek A, Cunningham, David, Wadsley, Jonathan, Darby, Suzanne, Meyer, Tim, Gillmore, Roopinder, Anthoney, Alan, Lind, Pehr, Glimelius, Bengt, Falk, Stephen, Izbicki, Jakob R, Middleton, Gary William, Cummins, Sebastian, Ross, Paul J, Wasan, Harpreet, McDonald, Alec, Crosby, Tom, Ting, Yuk, Patel, Kinnari, Sherriff, David, Soomal, Rubin, Borg, David, Sothi, Sharmila, Hammel, Pascal, Lerch, Markus M, Mayerle, Julia, Tjaden, Christine, Strobel, Oliver, Hackert, Thilo, Büchler, Markus W, Neoptolemos, John P

“…The patterns of disease recurrence after resection of pancreatic ductal adenocarcinoma with adjuvant chemotherapy remain unclear. To define patterns of…”
Get more information

Borderline resectable pancreatic cancer: A consensus statement by the International Study Group of Pancreatic Surgery (ISGPS) by Bockhorn, Maximilian, MD, Uzunoglu, Faik G., MD, Adham, Mustapha, MD, Imrie, Clem, MD, Milicevic, Miroslav, MD, Sandberg, Aken A., MD, Asbun, Horacio J., MD, Bassi, Claudio, MD, Büchler, Markus, MD, Charnley, Richard M., MD, Conlon, Kevin, MD, Cruz, Laureano Fernandez, MD, Dervenis, Christos, MD, Fingerhutt, Abe, MD, Friess, Helmut, MD, Gouma, Dirk J., MD, Hartwig, Werner, MD, Lillemoe, Keith D., MD, Montorsi, Marco, MD, Neoptolemos, John P., MD, Shrikhande, Shailesh V., MD, Takaori, Kyoichi, MD, Traverso, William, MD, Vashist, Yogesh K., MD, Vollmer, Charles, MD, Yeo, Charles J., MD, Izbicki, Jakob R., MD

“…Background This position statement was developed to expedite a consensus on definition and treatment for borderline resectable pancreatic ductal adenocarcinoma…”
Get full text

Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: A consensus statement by the International Study Group on Pancreatic Surgery (ISGPS) by Tol, Johanna A.M.G., MD, Gouma, Dirk J., MD, Bassi, Claudio, MD, Dervenis, Christos, MD, Montorsi, Marco, MD, Adham, Mustapha, MD, Andrén-Sandberg, Ake, MD, Asbun, Horacio J., MD, Bockhorn, Maximilian, MD, Büchler, Markus W., MD, Conlon, Kevin C., MD, Fernández-Cruz, Laureano, MD, Fingerhut, Abe, MD, Friess, Helmut, MD, Hartwig, Werner, MD, Izbicki, Jakob R., MD, Lillemoe, Keith D., MD, Milicevic, Miroslav N., MD, Neoptolemos, John P., MD, Shrikhande, Shailesh V., MD, Vollmer, Charles M., MD, Yeo, Charles J., MD, Charnley, Richard M., MD

“…Background The lymph node (Ln) status of patients with resectable pancreatic ductal adenocarcinoma is an important predictor of survival. The survival benefit…”
Get full text

Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid vs Gemcitabine Following Pancreatic Cancer Resection: A Randomized Controlled Trial by Neoptolemos, John P, Stocken, Deborah D, Bassi, Claudio, Ghaneh, Paula, Cunningham, David, Goldstein, David, Padbury, Robert, Moore, Malcolm J, Gallinger, Steven, Mariette, Christophe, Wente, Moritz N, Izbicki, Jakob R, Friess, Helmut, Lerch, Markus M, Dervenis, Christos, Oláh, Attila, Butturini, Giovanni, Doi, Ryuichiro, Lind, Pehr A, Smith, David, Valle, Juan W, Palmer, Daniel H, Buckels, John A, Thompson, Joyce, McKay, Colin J, Rawcliffe, Charlotte L, Büchler, Markus W, European Study Group for Pancreatic Cancer, for the

“…CONTEXT Adjuvant fluorouracil has been shown to be of benefit for patients with resected pancreatic cancer. Gemcitabine is known to be the most effective agent…”
Get full text

Effect of Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid or Gemcitabine vs Observation on Survival in Patients With Resected Periampullary Adenocarcinoma: The ESPAC-3 Periampullary Cancer Randomized Trial by Neoptolemos, John P, Moore, Malcolm J, Cox, Trevor F, Valle, Juan W, Palmer, Daniel H, McDonald, Alexander C, Carter, Ross, Tebbutt, Niall C, Dervenis, Christos, Smith, David, Glimelius, Bengt, Charnley, Richard M, Lacaine, François, Scarfe, Andrew G, Middleton, Mark R, Anthoney, Alan, Ghaneh, Paula, Halloran, Christopher M, Lerch, Markus M, Oláh, Attila, Rawcliffe, Charlotte L, Verbeke, Caroline S, Campbell, Fiona, Büchler, Markus W

“…CONTEXT Patients with periampullary adenocarcinomas undergo the same resectional surgery as that of patients with pancreatic ductal adenocarcinoma. Although…”
Get full text

Extended pancreatectomy in pancreatic ductal adenocarcinoma: Definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS) by Hartwig, Werner, MD, Vollmer, Charles M., MD, Fingerhut, Abe, MD, Yeo, Charles J., MD, Neoptolemos, John P., MD, Adham, Mustapha, MD, Andrén-Sandberg, Åke, MD, Asbun, Horacio J., MD, Bassi, Claudio, MD, Bockhorn, Max, MD, Charnley, Richard, MD, Conlon, Kevin C., MD, Dervenis, Christos, MD, Fernandez-Cruz, Laureano, MD, Friess, Helmut, MD, Gouma, Dirk J., MD, Imrie, Clem W., MD, Lillemoe, Keith D., MD, Milićević, Miroslav N., MD, Montorsi, Marco, MD, Shrikhande, Shailesh V., MD, Vashist, Yogesh K., MD, Izbicki, Jakob R., MD, Büchler, Markus W., MD

“…Background Complete macroscopic tumor resection is one of the most relevant predictors of long-term survival in pancreatic ductal adenocarcinoma. Because…”
Get full text

Impaired autophagy increases susceptibility to endotoxin-induced chronic pancreatitis by Xia, L., Xu, Z., Zhou, X., Bergmann, F., Grabe, N., Büchler, M. W., Neoptolemos, J. P., Hackert, T., Kroemer, G., Fortunato, F.

“…Chronic pancreatitis (CP) is associated with elevated plasma levels of bacterial lipopolysaccharide (LPS) and we have demonstrated reduced acinar cell…”
Get full text

UEG position paper on pancreatic cancer. Bringing pancreatic cancer to the 21st century: Prevent, detect, and treat the disease earlier and better by Michl, Patrick, Löhr, Matthias, Neoptolemos, John P., Capurso, Gabriele, Rebours, Vinciane, Malats, Nuria, Ollivier, Mathilde, Ricciardiello, Luigi

“…Background Pancreatic ductal adenocarcinoma is the deadliest cancer worldwide with a 98% loss‐of‐life expectancy and a 30% increase in the disability‐adjusted…”
Get full text

When to perform a pancreatoduodenectomy in the absence of positive histology? A consensus statement by the International Study Group of Pancreatic Surgery by Asbun, Horacio J., MD, Conlon, Kevin, MD, Fernandez-Cruz, Laureano, MD, Friess, Helmut, MD, Shrikhande, Shailesh V., MD, Adham, Mustapha, MD, Bassi, Claudio, MD, Bockhorn, Maximilian, MD, Büchler, Markus, MD, Charnley, Richard M., MD, Dervenis, Christos, MD, Fingerhutt, Abe, MD, Gouma, Dirk J., MD, Hartwig, Werner, MD, Imrie, Clem, MD, Izbicki, Jakob R., MD, Lillemoe, Keith D., MD, Milicevic, Miroslav, MD, Montorsi, Marco, MD, Neoptolemos, John P., MD, Sandberg, Aken A., MD, Sarr, Michael, MD, Vollmer, Charles, MD, Yeo, Charles J., MD, Traverso, L. William, MD

“…Background Pancreatoduodenectomy (PD) provides the best chance for cure in the treatment of patients with localized pancreatic head cancer. In patients with a…”
Get full text

A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer by Neoptolemos, John P, Stocken, Deborah D, Friess, Helmut, Bassi, Claudio, Dunn, Janet A, Hickey, Helen, Beger, Hans, Fernandez-Cruz, Laureano, Dervenis, Christos, Lacaine, François, Falconi, Massimo, Pederzoli, Paolo, Pap, Akos, Spooner, David, Kerr, David J, Büchler, Markus W

“…This randomized trial of adjuvant therapy after resection of pancreatic cancer found a significant survival benefit for chemotherapy with fluorouracil…”
Get full text