Search Results - "Nenke, Marni A"

Plasma corticosteroid‐binding globulin concentrations are preserved in mild cirrhosis by Lee, Jessica H., Nenke, Marni A., Flabouris, Katerina, Torpy, David J., Meyer, Emily J.

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Pyrexia and acidosis act independently of neutrophil elastase reactive center loop cleavage to effect cortisol release from corticosteroid‐binding globulin by Meyer, Emily J., Torpy, David J., Chernykh, Anastasia, Thaysen‐Andersen, Morten, Nenke, Marni A., Lewis, John G., Rajapaksha, Harinda, Rankin, Wayne, Polyak, Steven W.

“…Corticosteroid‐binding globulin (CBG) transports cortisol and other steroids. High‐affinity CBG (haCBG) undergoes proteolysis of the reactive center loop (RCL)…”
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High binding site occupancy of corticosteroid-binding globulin by progesterone increases fetal free cortisol concentrations by Hodyl, Nicolette A., Stark, Michael J., Meyer, Emily J., Lewis, John G., Torpy, David J., Nenke, Marni A.

“…Corticosteroid-binding globulin (CBG) binds and transports cortisol in the circulation in high cortisol-binding affinity (haCBG) and low affinity (laCBG)…”
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Continuous Subcutaneous Hydrocortisone Infusion Therapy in Addison's Disease: A Randomized, Placebo-Controlled Clinical Trial by Gagliardi, Lucia, Nenke, Marni A, Thynne, Tilenka R. J, von der Borch, Jenny, Rankin, Wayne A, Henley, David E, Sorbello, Jane, Inder, Warrick J, Torpy, David J

“…Context: Patients with Addison's disease (AD) report impaired subjective health status (SHS). Since cortisol exhibits a robust circadian cycle that entrains…”
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Low-dose hydrocortisone replacement improves wellbeing and pain tolerance in chronic pain patients with opioid-induced hypocortisolemic responses. A pilot randomized, placebo-controlled trial by Nenke, Marni A, Haylock, Clare L, Rankin, Wayne, Inder, Warrick J, Gagliardi, Lucia, Eldridge, Crystal, Rolan, Paul, Torpy, David J

“…Highlights • This is the first RCT of glucocorticoid replacement in CNCP with hypocortisolemia. • Low-dose hydrocortisone improves vitality and pain in LTOT…”
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Corticosteroid-binding globulin cleavage is paradoxically reduced in alpha-1 antitrypsin deficiency: Implications for cortisol homeostasis by Nenke, Marni A., Holmes, Mark, Rankin, Wayne, Lewis, John G., Torpy, David J.

“…High-affinity corticosteroid-binding globulin (haCBG) is cleaved by neutrophil elastase (NE) resulting in permanent transition to the low cortisol-binding…”
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Psychosis and cardiovascular disease: Is diet the missing link? by Nenke, Marni A, Hahn, Lisa A, Thompson, Campbell H, Liu, Dennis, Galletly, Cherrie A

“…Abstract Objective To explore the diets of people living with psychotic disorders, and to compare their dietary composition to the general population. Method…”
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Total and high‐affinity corticosteroid‐binding globulin depletion in septic shock is associated with mortality by Meyer, Emily J., Nenke, Marni A., Rankin, Wayne, Lewis, John G., Konings, Elisabeth, Slager, Maarten, Jansen, Tim C., Bakker, Jan, Hofland, Johannes, Feelders, Richard A., Torpy, David J.

“…Summary Context Corticosteroid‐binding globulin (CBG) and albumin transport circulating cortisol. Cleavage of high‐affinity CBG (haCBG) by neutrophil elastase…”
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Corticosteroid-binding globulin cleavage may be pathogen-dependent in bloodstream infection by Nenke, Marni A, Lewis, John G, Rankin, Wayne, Shaw, David, Torpy, David J

“…The process of enzymatic cleavage of high- to low-affinity corticosteroid-binding globulin (haCBG to laCBG) by neutrophil elastase leads to local tissue…”
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Reduced corticosteroid-binding globulin cleavage in active rheumatoid arthritis by Nenke, Marni A., Lewis, John G., Rankin, Wayne, McWilliams, Leah, Metcalf, Robert G., Proudman, Susanna M., Torpy, David J.

“…Summary Objective Corticosteroid‐binding globulin (CBG), the cortisol transport protein, is cleaved from high‐affinity (haCBG) to low‐affinity (laCBG) CBG at…”
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Serum N -Glycomics Stratifies Bacteremic Patients Infected with Different Pathogens by Chatterjee, Sayantani, Kawahara, Rebeca, Tjondro, Harry C, Shaw, David R, Nenke, Marni A, Torpy, David J, Thaysen-Andersen, Morten

“…Bacteremia-i.e., the presence of pathogens in the blood stream-is associated with long-term morbidity and is a potential precursor condition to…”
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Differential Effects of Estrogen on Corticosteroid-Binding Globulin Forms Suggests Reduced Cleavage in Pregnancy by Nenke, Marni A, Zeng, Anna, Meyer, Emily J, Lewis, John G, Rankin, Wayne, Johnston, Julie, Kireta, Svjetlana, Jesudason, Shilpanjali, Torpy, David J

“…Corticosteroid-binding globulin (CBG) is secreted as high-affinity CBG (haCBG), which may be cleaved by tissue proteases to low-affinity CBG (laCBG), releasing…”
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Depletion of high-affinity corticosteroid-binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications by Nenke, M.A., Rankin, W., Chapman, M.J., Stevens, N.E., Diener, K.R., Hayball, J. D., Lewis, J.G., Torpy, D.J.

“…Summary Objective Corticosteroid‐binding globulin (CBG) is cleaved by neutrophil elastase converting the high‐affinity (haCBG) conformation of CBG to a…”
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