Search Results - "Nencini, Arianna"

Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells by De Robertis, Alessandra, Valensin, Silvia, Rossi, Marco, Tunici, Patrizia, Verani, Margherita, De Rosa, Antonella, Giordano, Cinzia, Varrone, Maurizio, Nencini, Arianna, Pratelli, Carmela, Benicchi, Tiziana, Bakker, Annette, Hill, Jeffrey, Sangthongpitag, Kanda, Pendharkar, Vishal, Liu, Boping, Ng, Fui Mee, Then, Siew Wen, Jing Tai, Shi, Cheong, Seong-Moon, He, Xi, Caricasole, Andrea, Salerno, Massimiliano

“…Glioblastoma multiforme (GBM) is the most common and prognostically unfavorable form of brain tumor. The aggressive and highly invasive phenotype of these…”
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siRNA screen identifies QPCT as a druggable target for Huntington's disease by Jimenez-Sanchez, Maria, Lam, Wun, Hannus, Michael, Sönnichsen, Birte, Imarisio, Sara, Fleming, Angeleen, Tarditi, Alessia, Menzies, Fiona, Ed Dami, Teresa, Xu, Catherine, Gonzalez-Couto, Eduardo, Lazzeroni, Giulia, Heitz, Freddy, Diamanti, Daniela, Massai, Luisa, Satagopam, Venkata P, Marconi, Guido, Caramelli, Chiara, Nencini, Arianna, Andreini, Matteo, Sardone, Gian Luca, Caradonna, Nicola P, Porcari, Valentina, Scali, Carla, Schneider, Reinhard, Pollio, Giuseppe, O'Kane, Cahir J, Caricasole, Andrea, Rubinsztein, David C

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siRNA screen identifies QPCT as a druggable target for Huntington's disease by Jimenez-Sanchez, Maria, Lam, Wun, Hannus, Michael, Sönnichsen, Birte, Imarisio, Sara, Fleming, Angeleen, Tarditi, Alessia, Menzies, Fiona, Ed Dami, Teresa, Xu, Catherine, Gonzalez-Couto, Eduardo, Lazzeroni, Giulia, Heitz, Freddy, Diamanti, Daniela, Massai, Luisa, Satagopam, Venkata P, Marconi, Guido, Caramelli, Chiara, Nencini, Arianna, Andreini, Matteo, Sardone, Gian Luca, Caradonna, Nicola P, Porcari, Valentina, Scali, Carla, Schneider, Reinhard, Pollio, Giuseppe, O'Kane, Cahir J, Caricasole, Andrea, Rubinsztein, David C

“…An siRNA screen for genes that suppress mutant huntingtin toxicity in both mammalian cells and Drosophila identifies glutaminyl cyclase (QPCT). Newly generated…”
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Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor by Nencini, Arianna, Castaldo, Cristiana, Comery, Thomas A, Dunlop, John, Genesio, Eva, Ghiron, Chiara, Haydar, Simon, Maccari, Laura, Micco, Iolanda, Turlizzi, Elisa, Zanaletti, Riccardo, Zhang, Jean

“…α7 nicotinic acetylcholine receptor agonists are promising therapeutic candidates for the treatment of cognitive impairment. As a follow up of our internal…”
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Discovery of a Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonist Series and Characterization of the Potent, Selective, and Orally Efficacious Agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic Acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] Amide (SEN15924, WAY-361789) by Zanaletti, Riccardo, Bettinetti, Laura, Castaldo, Cristiana, Cocconcelli, Giuseppe, Comery, Thomas, Dunlop, John, Gaviraghi, Giovanni, Ghiron, Chiara, Haydar, Simon N, Jow, Flora, Maccari, Laura, Micco, Iolanda, Nencini, Arianna, Scali, Carla, Turlizzi, Elisa, Valacchi, Michela

“…Alpha-7 nicotinic acetylcholine receptors (α7 nAChR) are implicated in the modulation of many cognitive functions such as attention, working memory, and…”
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Identification of 2-aminopyrimidine derivatives as inhibitors of the canonical Wnt signaling pathway by Del Bello, Fabio, Farande, Aniket, Giannella, Mario, Piergentili, Alessandro, Quaglia, Wilma, Benicchi, Tiziana, Cappelli, Federico, Nencini, Arianna, Salerno, Massimiliano, Thomas, Russell J., Travagli, Massimilano, Varrone, Maurizio

“…[Display omitted] The canonical Wnt signaling pathway plays a fundamental role in embryonic as well as in adult development. Consequently, dysregulation of the…”
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Structure–activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway by Nencini, Arianna, Pratelli, Carmela, Quinn, Joanna M., Salerno, Massimiliano, Tunici, Patrizia, De Robertis, Alessandra, Valensin, Silvia, Mennillo, Federica, Rossi, Marco, Bakker, Annette, Benicchi, Tiziana, Cappelli, Federico, Turlizzi, Elisa, Nibbio, Martina, Caradonna, Nicola P., Zanelli, Ugo, Andreini, Matteo, Magnani, Matteo, Varrone, Maurizio

“…Wnt signaling pathway plays a critical role in numerous cellular processes, including tumor initiation, proliferation, invasion/infiltration, metastasis…”
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N‑[5-(5-Fluoropyridin-3-yl)‑1H‑pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate by Zanaletti, Riccardo, Bettinetti, Laura, Castaldo, Cristiana, Ceccarelli, Ilaria, Cocconcelli, Giuseppe, Comery, Thomas A, Dunlop, John, Genesio, Eva, Ghiron, Chiara, Haydar, Simon N, Jow, Flora, Maccari, Laura, Micco, Iolanda, Nencini, Arianna, Pratelli, Carmela, Scali, Carla, Turlizzi, Elisa, Valacchi, Michela

“…α7 nicotinic acetylcholine receptors (α7 nAChR) represent promising therapeutic candidates for the treatment of cognitive impairment associated with…”
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Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914) by Ghiron, Chiara, Haydar, Simon N, Aschmies, Suzan, Bothmann, Hendrick, Castaldo, Cristiana, Cocconcelli, Giuseppe, Comery, Thomas A, Di, Li, Dunlop, John, Lock, Tim, Kramer, Angela, Kowal, Dianne, Jow, Flora, Grauer, Steve, Harrison, Boyd, La Rosa, Salvatore, Maccari, Laura, Marquis, Karen L, Micco, Iolanda, Nencini, Arianna, Quinn, Joanna, Robichaud, Albert J, Roncarati, Renza, Scali, Carla, Terstappen, Georg C, Turlizzi, Elisa, Valacchi, Michela, Varrone, Maurizio, Zanaletti, Riccardo, Zanelli, Ugo

“…Alpha-7 nicotinic acetylcholine receptor (α7 nAChR) agonists are promising therapeutic candidates for the treatment of cognitive impairment. We report a series…”
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Abstract LB-209: Identification and characterization of small molecule inhibitor of Wnt canonical pathway in a glioma setting by Robertis, Alessandra De, Valensin, Silvia, Rossi, Marco, Verani, Margherita, Tunici, Patrizia, Rosa, Antonella De, Giordano, Cinzia, Varrone, Maurizio, Nencini, Arianna, Pratelli, Carmela, Bakker, Annette, Salerno, Massimiliano

“…Abstract Glioblastoma multiforme (GBM) is the most common and aggressive form of brain tumors. The aggressive and highly invasive phenotype of these tumors…”
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Parallel synthesis of a series of potentially brain penetrant aminoalkyl benzoimidazoles by Micco, Iolanda, Nencini, Arianna, Quinn, Joanna, Bothmann, Hendrick, Ghiron, Chiara, Padova, Alessandro, Papini, Silvia

“…Alpha7 agonists were identified via GOLD (CCDC) docking in the putative agonist binding site of an alpha7 homology model and a series of aminoalkyl…”
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