СORRECTION OF AUTOIMMUNE GLOMERULONEPHRITIS BY LETHAL IRRADIATION AND TRANSFER OF SYNGENEIC BONE MARROW CELLS IN AN EXPERIMENTAL MODEL

Mice with lupus-like autoimmune glomerulonephritis induced by chronic graft-versus-host reaction, have been treated with irradiation at lethal doses, followed by injection of bone marrow cells from syngeneic donors. Following such treatment, the autoimmune process was interrupted, as judged by disap...

Full description

Saved in:

Bibliographic Details
Published in:	Medit͡s︡inskai͡a︡ immunologii͡a Vol. 12; no. 3; pp. 191 - 198
Main Authors:	Kudaeva, O. T., Goiman, E. V., Nenasheva, E. V., Majborodin, I. V., Kolesnikova, O. P., Kozlov, V. A.
Format:	Journal Article
Language:	English
Published:	St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 14-07-2014
Subjects:	autoimmune glomerulonephritis bone marrow transplantation chronic gvhd immune deficiency
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Mice with lupus-like autoimmune glomerulonephritis induced by chronic graft-versus-host reaction, have been treated with irradiation at lethal doses, followed by injection of bone marrow cells from syngeneic donors. Following such treatment, the autoimmune process was interrupted, as judged by disappearance of anti-DNA autoantibodies in peripheral blood. A drop in urine protein to normal values was also observed in the marrow recipients, thus being a characteristic sign of recovery from glomerulonephritis. Correction of the disease was confirmed by morphological data: the signs of oedema were diminished, and inflammatory reaction was found to be decreased in the kidneys of animals with lupus-like disorder after marrow transplantation.
ISSN:	1563-0625 2313-741X
DOI:	10.15789/1563-0625-2010-3-191-198