Search Results - "Nemeth, Jeffrey A"

JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling by Song, Lanxi, Rawal, Bhupendra, Nemeth, Jeffrey A, Haura, Eric B

“…Members of the signal transducer and activator of transcription (STAT) family of transcription factors are potential targets for the treatment and prevention…”
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Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function by Grugan, Katharine D, McCabe, Francis L, Kinder, Michelle, Greenplate, Allison R, Harman, Benjamin C, Ekert, Jason E, van Rooijen, Nico, Anderson, G Mark, Nemeth, Jeffrey A, Strohl, William R, Jordan, Robert E, Brezski, Randall J

“…Tumor-associated macrophages (TAMs) have been shown to promote tumor progression, and increased TAM infiltration often correlates with poor prognosis. However,…”
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Down-regulation of Suppressor of Cytokine Signaling-3 Causes Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways by PUHR, Martin, SANTER, Frédéric R, NEUWIRT, Hannes, SUSANI, Martin, NEMETH, Jeffrey A, HOBISCH, Alfred, KENNER, Lukas, CULIG, Zoran

“…Suppressor of cytokine signaling-3 (SOCS-3) acts as a negative feedback regulator of the Janus-activated kinase/signal transducers and activators of…”
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Inhibition of Interleukin-6 Signaling with CNTO 328 Enhances the Activity of Bortezomib in Preclinical Models of Multiple Myeloma by Voorhees, Peter M, Chen, Qing, Kuhn, Deborah J, Small, George W, Hunsucker, Sally A, Strader, John S, Corringham, Robert E, Zaki, Mohamed H, Nemeth, Jeffrey A, Orlowski, Robert Z

“…Purpose: Inhibition of the proteasome leads to the activation of survival pathways in addition to those that promote cell death. We hypothesized that…”
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CNTO 328, a monoclonal antibody to IL‐6, inhibits human tumor‐induced cachexia in nude mice by Zaki, Mohamed H., Nemeth, Jeffrey A., Trikha, Mohit

“…IL‐6 is a multifunctional cytokine implicated in several cancers. IL‐6 is a growth factor for certain tumors and contributes to drug resistance, cachexia and…”
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Phase I Evaluation of a Fully Human Anti–αv Integrin Monoclonal Antibody (CNTO 95) in Patients with Advanced Solid Tumors by MULLAMITHA, Saifee A, TON, Nhuan C, HOPE, Lynn, VALLE, Juan W, RADFORD, John A, LAWRANCE, Jeremy, SAUNDERS, Mark P, MUNTEANU, Mihaela C, NAKADA, Marian T, NEMETH, Jeffrey A, DAVIS, Hugh M, QUN JIAO, PARKER, Geoff J. M, PRABHAKAR, Uma, ZHIHUI LANG, CORRINGHAM, Robert E, BECKMAN, Robert A, JAYSON, Gordon C, JACKSON, Alan, JULYAN, Peter J, ROBERTS, Caleb, BUONACCORSI, Gio A, WATSON, Yvonne, DAVIES, Karen, CHEUNG, Sue

“…Purpose: A fully human monoclonal antibody to anti–α v integrins (CNTO 95) has been shown to inhibit angiogenesis and tumor growth in preclinical studies. We…”
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Circulating Human Interleukin-8 as an Indicator of Cancer Progression in a Nude Rat Orthotopic Human Non–Small Cell Lung Carcinoma Model by MILLAR, Hillary J, NEMETH, Jeffrey A, MCCABE, Francis L, PIKOUNIS, Bill, WICKSTROM, Eric

“…Clinically relevant animal models of human cancer are necessary for the evaluation of putative therapeutics. We hypothesized that circulating human lung…”
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Differential regulation of matrix metalloproteinase‐9, tissue inhibitor of metalloproteinase‐1 (TIMP‐1) and TIMP‐2 expression in co‐cultures of prostate cancer and stromal cells by Dong, Zhong, Nemeth, Jeffrey A., Cher, Michael L., Palmer, Kenneth C., Bright, Robert C., Fridman, Rafael

“…Tumor–stromal interactions have been suggested to be a critical factor in both tumor invasion and tumor metastasis. Here, we examined the role of tumor–stromal…”
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Absence of Adverse Effects in Cynomolgus Macaques Treated with CNTO 95, a Fully Human Anti-αv Integrin Monoclonal Antibody, Despite Widespread Tissue Binding by MARTIN, Pauline L, QUN JIAO, ANDERSON, Lisa, GRAHAM, Martin A, DAVIS, Hugh M, TREACY, George, CORNACOFF, Joel, HALL, William, SAVILLE, Bradley, NEMETH, Jeffrey A, SCHANTZ, Allen, MATA, Marielena, JANG, Haishan, FASANMADE, Adedigbo A

“…Purpose: CNTO 95 is a fully human anti-αv integrin monoclonal antibody that inhibits macaque and rodent angiogenesis and inhibits human tumor growth in…”
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Targeted inhibition of interleukin‐6 with CNTO 328 sensitizes pre‐clinical models of multiple myeloma to dexamethasone‐mediated cell death by Voorhees, Peter M., Chen, Qing, Small, George W., Kuhn, Deborah J., Hunsucker, Sally A., Nemeth, Jeffrey A., Orlowski, Robert Z.

“…Summary Interleukin (IL)‐6‐mediated signalling attenuates the anti‐myeloma activity of glucocorticoids (GCs). We therefore sought to evaluate whether CNTO 328,…”
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Blockade of interleukin‐6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma by Hunsucker, Sally A., Magarotto, Valeria, Kuhn, Deborah J., Kornblau, Steven M., Wang, Michael, Weber, Donna M., Thomas, Sheeba K., Shah, Jatin J., Voorhees, Peter M., Xie, Hong, Cornfeld, Mark, Nemeth, Jeffrey A., Orlowski, Robert Z.

“…Summary Signalling through the interleukin (IL)‐6 pathway induces proliferation and drug resistance of multiple myeloma cells. We therefore sought to determine…”
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Cyclophosphamide Creates a Receptive Microenvironment for Prostate Cancer Skeletal Metastasis by IN PARK, Serk, JINHUI LIAO, TISDELLE, Sandra, DAIGNAULT, Stephanie D, NEMETH, Jeffrey A, SNYDER, Linda A, WRONSKI, Thomas J, PIENTA, Kenneth J, MCCAULEY, Laurie K, BERRY, Janice E, XIN LI, KOH, Amy J, MICHALSKI, Megan E, EBER, Matthew R, SOKI, Fabiana N, SADLER, David, SUD, Sudha

“…A number of cancers predominantly metastasize to bone, due to its complex microenvironment and multiple types of constitutive cells. Prostate cancer especially…”
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Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice by WALLNER, Lauren, JINLU DAI, ESCARA-WILKE, June, JIAN ZHANG, ZHI YAO, YI LU, TRIKHA, Mohit, NEMETH, Jeffrey A, ZAKI, Mohamed H, KELLER, Evan T

“…Initially, prostate cancer is androgen dependent. However, most cases progress to an androgen-independent state through unknown mechanisms. Interleukin-6…”
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Matrix Metalloproteinase Activity, Bone Matrix Turnover, and Tumor Cell Proliferation in Prostate Cancer Bone Metastasis by Nemeth, Jeffrey A., Yousif, Rafid, Herzog, Michael, Che, Mingxin, Upadhyay, Jyoti, Shekarriz, Bijan, Bhagat, Sunita, Mullins, Chadwick, Fridman, Rafael, Cher, Michael L.

“…Background: The metastasis of prostate cancer to bone is associated with a substantial increase in bone matrix turnover. Matrix metalloproteinases (MMPs) play…”
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Alpha-v Integrins as Therapeutic Targets in Oncology by Nemeth, Jeffrey A., Nakada, Marian T., Trikha, M., Lang, Zhihui, Gordon, Michael S., Jayson, Gordon C., Corringham, Robert, Prabhakar, Uma, Davis, Hugh M., Beckman, Robert A.

“…Integrins are heterodimeric cell adhesion receptors that mediate intercellular communication through cell-extracellular matrix interactions and cell-cell…”
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Mcl-1 is regulated by IL-6 and mediates the survival activity of the cytokine in a model of late stage prostate carcinoma by Cavarretta, Ilaria Teresa, Neuwirt, Hannes, Zaki, Mohamed H, Steiner, Hannes, Hobisch, Alfred, Nemeth, Jeffrey A, Culig, Zoran

“…The proinflammatory cytokine interleukin-6 (IL-6) has been considered a positive growth factor in late stage prostate cancer (PC) cells and a potential target…”
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Anti-integrin monoclonal antibody CNTO 95 enhances the therapeutic efficacy of fractionated radiation therapy in vivo by Ning, Shoucheng, Nemeth, Jeffrey A, Hanson, Rebecca L, Forsythe, Kevin, Knox, Susan J

“…Selective targeting of up-regulated integrins on tumor cells is a novel antiangiogenesis strategy for treating solid tumors. CNTO 95 is a fully human…”
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Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone by NEMETH, J. A, HARB, J. F, BARROSO, U. JR, ZHANQUAN HE, GRIGNON, D. J, CHER, M. L

“…Commonly used in vivo models of prostate cancer metastasis include syngeneic rodent cancers and xenografts of human cancer in immunodeficient mice. However,…”
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Regulation of growth of prostate cancer cells selected in the presence of interleukin-6 by the anti-interleukin-6 antibody CNTO 328 by Steiner, Hannes, Cavarretta, Ilaria T., Moser, Patrizia L., Berger, Andreas P., Bektic, Jasmin, Dietrich, Hermann, Zaki, Mohamed H., Nakada, Marian, Hobisch, Alfred, Nemeth, Jeffrey A., Culig, Zoran

“…BACKGROUND Interleukin‐6 (IL‐6) is a multifunctional regulator of cellular events in prostate cancer. LNCaP‐IL‐6+ cells selected in the presence of IL‐6 were…”
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Role for β3 integrins in human melanoma growth and survival by Trikha, Mohit, Timar, Jozsef, Zacharek, Alex, Nemeth, Jeffrey A., Cai, Yinlong, Dome, Balazs, Somlai, Beata, Raso, Elisabeth, Ladanyi, Andrea, Honn, Kenneth V.

“…The role of αIIbβ3 integrin in regulating platelet function is well appreciated, whereas its role in tumor progression and metastasis is not. The purpose of…”
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