Search Results - "Nemes, Zoltán"

Synthesis and Evaluation of Phosphorus Containing, Specific CDK9/CycT1 Inhibitors by Németh, Gábor, Greff, Zoltán, Sipos, Anna, Varga, Zoltán, Székely, Rita, Sebestyén, Mónika, Jászay, Zsuzsa, Béni, Szabolcs, Nemes, Zoltán, Pirat, Jean-Luc, Volle, Jean-Noël, Virieux, David, Gyuris, Ágnes, Kelemenics, Katalin, Áy, Éva, Minarovits, Janos, Szathmary, Susan, Kéri, György, Őrfi, László

“…Although there is a significant effort in the design of a selective CDK9/CycT1 inhibitor, no compound has been proven to be a specific inhibitor of this kinase…”
Get full text

State and role of water confined in cement and composites modified with metakaolin and additives by Papp, Vanda, Janovics, Róbert, Péter Kertész, Tamás, Nemes, Zoltán, Fodor, Tamás, Bányai, István, Kéri, Mónika

“…[Display omitted] •High- and low-field NMR study of mesoporous cement- and metakaolin-based binders.•Formation and nanoscale structure of cement-based…”
Get full text

Isopeptidase activity of human transglutaminase 2: disconnection from transamidation and characterization by kinetic parameters by Király, Róbert, Thangaraju, Kiruphagaran, Nagy, Zsófia, Collighan, Russell, Nemes, Zoltán, Griffin, Martin, Fésüs, László

“…Transglutaminase 2 (TG2) is a multifunctional protein with diverse catalytic activities and biological roles. Its best studied function is the Ca²⁺-dependent…”
Get full text

Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases by Baska, Ferenc, Sipos, Anna, Őrfi, Zoltán, Nemes, Zoltán, Dobos, Judit, Szántai-Kis, Csaba, Szabó, Eszter, Szénási, Gábor, Dézsi, László, Hamar, Péter, Cserepes, Mihály T., Tóvári, József, Garamvölgyi, Rita, Krekó, Marcell, Őrfi, László

“…Aberrant activation of FMS-like tyrosine receptor kinase 3 (FLT3) is implicated in the pathogenesis of acute myeloid leukemia (AML) in 20–30% of patients. In…”
Get full text

Synthesis and characterization of amino acid substituted sunitinib analogues for the treatment of AML by Nemes, Zoltán, Takács-Novák, Krisztina, Völgyi, Gergely, Valko, Klara, Béni, Szabolcs, Horváth, Zoltán, Szokol, Bálint, Breza, Nóra, Dobos, Judit, Szántai-Kis, Csaba, Illyés, Eszter, Boros, Sándor, Kok, Robbert Jan, Őrfi, László

“…[Display omitted] •62 amino acid substituted sunitinib analogues were synthesized, inhibiting FLT3-ITD kinase and AML cell line.•Physical-chemical properties…”
Get full text

Transglutaminase-mediated Intramolecular Cross-linking of Membrane-bound α-Synuclein Promotes Amyloid Formation in Lewy Bodies by Nemes, Zoltán, Petrovski, Goran, Aerts, Maarten, Sergeant, Kjell, Devreese, Bart, Fésüs, László

“…The α-synuclein immunopositive and chaotrope-insoluble material from human brains with Lewy body pathology was analyzed by mass spectrometry. From the…”
Get full text

A Novel Function for Transglutaminase 1: Attachment of Long-Chain ω -Hydroxyceramides to Involucrin by Ester Bond Formation by Nemes, Zoltán, Marekov, Lyuben N., Fésüs, Lázló, Steinert, Peter M.

“…Transglutaminases (TGases) are defined as enzymes capable of forming isopeptide bonds by transfer of an amine onto glutaminyl residues of a protein. Here we…”
Get full text

Effect of IBD sera on expression of inducible and endothelial nitric oxide synthase in human umbilical vein endothelial cells by Palatka, Károly

“…AIM： To study the expression of endothelial and inducible nitric oxide synthases （eNOS and iNOS） and their role in inflammatory bowel disease （IBD）. METHODS：…”
Get full text

Changes in the expression and distribution of the inducible and endothelial nitric oxide synthase in mucosal biopsy specimens of inflammatory bowel disease by Palatka, Károly, Serf z, Zoltán, Veréb, Zoltán, Hargitay, Zoltán, Lontay, Bea, Erd di, Ferenc, Bánfalvi, Gáspár, Nemes, Zoltán, Udvardy, Miklós, Altorjay, István

“…Objective The role of nitric oxide (NO) in the pathophysiology of inflammatory bowel disease (IBD) is controversial. The aim of this study was to investigate…”
Get full text

Methods to analyze transglutamination of proteins involved in apoptosis by Nemes, Zoltán, Fésüs, László

“…Enhanced expression of transglutaminases is a frequent, though not obligatory phenomenon in apoptosis, which is associated with cells dying in steady…”
Get more information

Pathology of chronic obstructive pulmonary disease by Szilasi, Mária, Dolinay, Tamás, Nemes, Zoltán, Strausz, János

“…Chronic obstructive pulmonary disease is one of the leading causes of death and morbidity worldwide. Despite intensive investigation, its pathology and…”
Get full text

Primary rhabdoid cancer of the ileum: A case report and review of the literature by Tóth, László, Nemes, Zoltán, Gomba, Szabolcs, Asztalos, László, Molnár, Csaba, András, Csilla, Szentirmay, Zoltán, Molnár, Péter

“…Since the first publication of a rhabdoid cancer, described as an infrequent variant of Wilms’ tumor, several cases of extrarenal rhabdoid tumor have been…”
Get full text

Differentiation markers in hemangiopericytoma by Nemes, Z

“…Normal pericytes were found to express factor XIIIa (F-XIII) and histocompatibility antigen HLA-DR. These markers were studied in 15 hemangiopericytomas (HPC)…”
Get more information

TASK-3 immunoreactivity shows differential distribution in the human gastrointestinal tract by KOVACS, Ilona, POCSAI, Krisztina, CZIFRA, Gabriella, SARKADI, Laszlo, SZUCS, Géza, NEMES, Zoltan, RUSZNAK, Zoltan

“…The presence and distribution of TASK-3 immunopositivity (a channel with potential oncogenic significance) was investigated in the human gastrointestinal…”
Get full text

The role of microglia/macrophage system in the tissue response to I-125 interstitial brachytherapy of cerebral gliomas by Julow, Jenő, Szeifert, György T., Bálint, Katalin, Nyáry, István, Nemes, Zoltán

“…Objective: To study histopathologic changes and the role of the microglia/macrophage cell in the therapeutic effect of I-125 interstitial brachytherapy on the…”
Get full text

Characterization of a new disease-causing mutation of SH2D1A in a family with X-linked lymphoproliferative disease by Erdõs, Melinda, Uzvölgyi, Éva, Nemes, Zoltán, Török, Olga, Rákóczi, Éva, Went-Sümegi, Nils, Sümegi, János, Maródi, László

“…Males with an expressed mutation in the SH2D1A gene that encodes an SH2 domain protein named SH2D1A or SAP (NP_002342; signaling lymphocyte activating molecule…”
Get full text

Identification of Cytoplasmic Actin as an Abundant Glutaminyl Substrate for Tissue Transglutaminase in HL-60 and U937 Cells Undergoing Apoptosis by Nemes, Zoltán, Adány, Róza, Balázs, Margit, Boross, Peter, Fésüs, László

“…A lysine derivative, 3-[Nα[Nε-[2′,4′-dinitrophenyl]-amino-n-hexanoyl-l-lysylamido]-propane-1-ol, a novel amine substrate of transglutaminases, was synthesized…”
Get full text

Transformed dermatofibrosarcoma protuberans: real time polymerase chain reaction detection of COL1A1–PDGFB fusion transcripts in sarcomatous areas by Szollosi, Zoltan, Scholtz, Beata, Egervari, Kristof, Nemes, Zoltan

“…Background: Recent cytogenetic studies have shown that reciprocal translocation t (17;22)(q22;q13) and a supernumerary ring chromosome derived from the…”
Get full text

Clinical decision making and outcome in routine care for people with severe mental illness (CEDAR): study protocol by Puschner, Bernd, Steffen, Sabine, Slade, Mike, Kaliniecka, Helena, Maj, Mario, Fiorillo, Andrea, Munk-Jørgensen, Povl, Larsen, Jens Ivar, Egerházi, Anikó, Nemes, Zoltan, Rössler, Wulf, Kawohl, Wolfram, Becker, Thomas

“…A considerable amount of research has been conducted on clinical decision making (CDM) in short-term physical conditions. However, there is a lack of knowledge…”
Get full text

Development of a Cell-Selective and Intrinsically Active Multikinase Inhibitor Bioconjugate by Harmsen, Stefan, Dolman, M. Emmy M, Nemes, Zoltan, Lacombe, Marie, Szokol, Bálint, Pató, János, Kéri, György, Őrfi, László, Storm, Gert, Hennink, Wim E, Kok, Robbert J

“…Multikinase inhibitors are potent anticancer drugs that simultaneously intervene in multiple related signaling cascades, thus being capable of blocking salvage…”
Get full text