Search Results - "Nemec, Antonia A."

Autophagic clearance of proteasomes in yeast requires the conserved sorting nexin Snx4 by Nemec, Antonia A., Howell, Lauren A., Peterson, Anna K., Murray, Matthew A., Tomko, Robert J.

“…Turnover of the 26S proteasome by autophagy is an evolutionarily conserved process that governs cellular proteolytic capacity and eliminates inactive…”
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A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation by Yamtich, Jennifer, Nemec, Antonia A, Keh, Agnes, Sweasy, Joann B

“…Several germline single nucleotide polymorphisms (SNPs) have been identified in the POLB gene, but little is known about their cellular and biochemical impact…”
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Variant base excision repair proteins: Contributors to genomic instability by Nemec, Antonia A, Wallace, Susan S, Sweasy, Joann B

“…Abstract Cells sustain endogenous DNA damage at rates greater than 20,000 DNA lesions per cell per day. These damages occur largely as a result of the…”
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An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes by Nemec, Antonia A., Peterson, Anna K., Warnock, Jennifer L., Reed, Randi G., Tomko, Robert J.

“…The 26S proteasome is the central ATP-dependent protease in eukaryotes and is essential for organismal health. Proteasome assembly is mediated by several…”
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A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation by Sjolund, Ashley, Nemec, Antonia A, Paquet, Nicolas, Prakash, Aishwarya, Sung, Patrick, Doublié, Sylvie, Sweasy, Joann B

“…Thymine DNA glycosylase (TDG) functions in base excision repair, a DNA repair pathway that acts in a lesion-specific manner to correct individual damaged or…”
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An unstructured proteasome inhibitor comes into focus by Nemec, Antonia A., Tomko, Robert J.

“…The inhibitory mechanism of an intrinsically disordered proteasome inhibitor identified over 30 years ago has finally been revealed by cryo-electron microscopy…”
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Cr(VI)-stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck by O'Hara, Kimberley A, Vaghjiani, Rasilaben J, Nemec, Antonia A, Klei, Linda R, Barchowsky, Aaron

“…Chronic inhalation of low amounts of Cr(VI) promotes pulmonary diseases and cancers through poorly defined mechanisms. SFKs (Src family kinases) in pulmonary…”
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A suite of PCR-based peptide tagging plasmids to permit epitope-targeted enzymatic functionalization of yeast proteins by Nemec, Antonia A, Tomko, Jr, Robert J

“…The budding yeast and model eukaryote Saccharomyces cerevisiae has been invaluable for purification and analysis of numerous evolutionarily conserved proteins…”
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A suite of polymerase chain reaction‐based peptide tagging plasmids for epitope‐targeted enzymatic functionalization of yeast proteins by Nemec, Antonia A., Tomko, Robert J.

“…The budding yeast and model eukaryote Saccharomyces cerevisiae has been invaluable for purification and analysis of numerous evolutionarily conserved proteins…”
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Human POLB Gene Is Mutated in High Percentage of Colorectal Tumors by Donigan, Katherine A., Sun, Ka-wai, Nemec, Antonia A., Murphy, Drew L., Cong, Xiangyu, Northrup, Veronika, Zelterman, Daniel, Sweasy, Joann B.

“…Previous small scale sequencing studies have indicated that DNA polymerase β (pol β) variants are present on average in 30% of human tumors of varying tissue…”
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Neovascularization and angiogenic gene expression following chronic arsenic exposure in mice by Soucy, Nicole V, Mayka, Debra, Klei, Linda R, Nemec, Antonia A, Bauer, John A, Barchowsky, Aaron

“…Exposure to arsenic in drinking water increases incidence of cardiovascular diseases. However, the basic mechanisms and genetic changes that promote these…”
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DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy by Nemec, Antonia A, Abriola, Laura, Merkel, Jane S, de Stanchina, Elisa, DeVeaux, Michelle, Zelterman, Daniel, Glazer, Peter M, Sweasy, Joann B

“…Resistance to cancer chemotherapies leads to deadly consequences, yet current research focuses only on the roles of somatically acquired mutations in this…”
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Colon Cancer-associated DNA Polymerase β Variant Induces Genomic Instability and Cellular Transformation by Nemec, Antonia A., Donigan, Katherine A., Murphy, Drew L., Jaeger, Joachim, Sweasy, Joann B.

“…Rapidly advancing technology has resulted in the generation of the genomic sequences of several human tumors. We have identified several mutations of the DNA…”
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Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β by Eckenroth, Brian E, Towle-Weicksel, Jamie B, Nemec, Antonia A, Murphy, Drew L, Sweasy, Joann B, Doublié, Sylvie

“…With the formidable growth in the volume of genetic information, it has become essential to identify and characterize mutations in macromolecules not only to…”
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The S229L Colon Tumor-associated Variant of DNA Polymerase β Induces Cellular Transformation as a Result of Decreased Polymerization Efficiency by Nemec, Antonia A., Murphy, Drew L., Donigan, Katherine A., Sweasy, Joann B.

“…DNA polymerase β (Pol β) plays a key role in base excision repair (BER) by filling in small gaps that are generated after base adducts are excised from the…”
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The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation by Galick, Heather A, Marsden, Carolyn G, Kathe, Scott, Dragon, Julie A, Volk, Lindsay, Nemec, Antonia A, Wallace, Susan S, Prakash, Aishwarya, Doublié, Sylvie, Sweasy, Joann B

“…Base excision repair (BER) is a key genome maintenance pathway. The NEIL1 DNA glycosylase recognizes oxidized bases, and likely removes damage in advance of…”
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Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein by Nemec, Antonia A, Bush, Korie B, Towle-Weicksel, Jamie B, Taylor, B Frazier, Schulz, Vincent, Weidhaas, Joanne B, Tuck, David P, Sweasy, Joann B

“…Repair of DNA damage is critical for maintaining the genomic integrity of cells. DNA polymerase lambda (POLL/Pol λ) is suggested to function in base excision…”
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Signal Transducer and Activator of Transcription 1 (STAT1) is Essential for Chromium Silencing of Gene Induction in Human Airway Epithelial Cells by Nemec, Antonia A., Barchowsky, Aaron

“…Hexavalent chromium (Cr(VI)) promotes lung injury and pulmonary diseases through poorly defined mechanisms that may involve the silencing of inducible…”
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Nickel Mobilizes Intracellular Zinc to Induce Metallothionein in Human Airway Epithelial Cells by Nemec, Antonia A, Leikauf, George D, Pitt, Bruce R, Wasserloos, Karla J, Barchowsky, Aaron

“…We recently reported that induction of metallothionein (MT) was critical in limiting nickel (Ni)-induced lung injury in intact mice. Nonetheless, the mechanism…”
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Chromium(VI) Stimulates Fyn to Initiate Innate Immune Gene Induction in Human Airway Epithelial Cells by Nemec, Antonia A, Zubritsky, Lindsey M, Barchowsky, Aaron

“…Mechanisms for pathogenic metal signaling in airway injury or disease promotion are poorly understood. It is widely believed that one mechanism for pathogenic…”
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