Search Results - "Nemazee, D"

Receptor Selection in B and T Lymphocytes by Nemazee, David

“…The process of clonal selection is a central feature of the immune system, but immune specificity is also regulated by receptor selection, in which the fate of…”
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Toll-like receptors and antibody responses by Nemazee, D., Gavin, A., Hoebe, K., Beutler, B.

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Immunology Toll-like receptors and antibody responses by Gavin, A, Nemazee, D, Hoebe, K, Beutler, B

“…Arising from: C. Pasare & R. Medzhitov Nature 438, 364-368 (2005); Pasare & Medzhitov reply.Microbial components, such as lipopolysaccharides, augment immune…”
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Contribution of Receptor Editing to the Antibody Repertoire by Casellas, Rafael, Shih, Tien-An Yang, Kleinewietfeld, Markus, Rakonjac, Jasna, Nemazee, David, Rajewsky, Klaus, Nussenzweig, Michel C.

“…Receptor editing, clonal deletion, and anergy are the mechanisms by which B cells maintain tolerance to self antigens. To determine the extent to which…”
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Receptor editing in self-reactive bone marrow B cells by TIEGS, S. L, RUSSELL, D. M, NEMAZEE, D

“…A central paradigm of immunology is clonal selection: lymphocytes displaying clonally distributed antigen receptors are generated and subsequently selected by…”
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Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes by Nemazee, David A, Bürki, Kurt

“…B lymphocytes can be rendered specifically unresponsive to antigen by experimental manipulation in vivo and in vitro, but it remains unclear whether or not…”
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Clonal Deletion of Autoreactive B Lymphocytes in Bone Marrow Chimeras by Nemazee, David, Buerki, Kurt

“…To study the fate of developing B cells in the presence and absence of the autoantigens to which they react, chimeric mice were constructed by injecting bone…”
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Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice by SPANOPOULOU, E, ROMAN, C. A. J, CORCORAN, L. M, SCHLISSEL, M. S, SILVER, D. P, NEMAZEE, D, NUSSENZWEIG, M. C, SHINTON, S. A, HARDY, R. R, BALTIMORE, D

“…We have examined the regulatory role of the individual components of the immunoglobulin antigen receptor in B-cell development by transgenic complementation of…”
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Rational immunogen design to target specific germline B cell receptors by Jardine, J, Kalyuzhniy, O, Ota, T, McGuire, A, Menis, S, Julien, J, Falkowska, E, MacPherson, S, Jones, M, Burton, DR, Wilson, IA, Stamatatos, L, Nemazee, D, Schief, WR

“…Doc number: O71…”
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Engineered mice and B cell lines expressing broadly neutralizing antibodies and their unmutated precursors: tools for HIV vaccinology by Nemazee, D, Doyle-Cooper, C, Ota, T, Cooper, AB, Huber, M, Falkowska, E, Doores, K, Hangartner, L, Le, K, Sok, D, Jardine, J, Lifson, J, Wu, X, Mascola, JR, Poignard, P, Binley, JM, Chakrabarti, BK, Schief, WR, Wyatt, RT, Burton, DR

“…Doc number: O41…”
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Unexpected autoantibody production in membrane Ig-mu-deficient/lpr mice by Melamed, D, Miri, E, Leider, N, Nemazee, D

“…In the B lymphocyte lineage, Fas-mediated cell death is important in controlling activated mature cells, but little is known about possible functions at…”
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B-cell antigen receptor competence regulates B-lymphocyte selection and survival by Buhl, A M, Nemazee, D, Cambier, J C, Rickert, R, Hertz, M

“…Experimental evidence contradicts the simplistic view that during development all B cells expressing non autoreactive antigen receptors on the cell surface are…”
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Role of B cell antigen receptor in regulation of V(D)J recombination and cell survival by Nemazee, D

“…B lymphocytes learn through the interaction of the B cell receptor with antigens in the context of B cell developmental stage and environmental cues. B cells…”
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In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice by Nahmad, Alessio D., Lazzarotto, Cicera R., Zelikson, Natalie, Kustin, Talia, Tenuta, Mary, Huang, Deli, Reuveni, Inbal, Nataf, Daniel, Raviv, Yuval, Horovitz-Fried, Miriam, Dotan, Iris, Carmi, Yaron, Rosin-Arbesfeld, Rina, Nemazee, David, Voss, James E., Stern, Adi, Tsai, Shengdar Q., Barzel, Adi

“…Transplantation of B cells engineered ex vivo to secrete broadly neutralizing antibodies (bNAbs) has shown efficacy in disease models. However, clinical…”
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Immune complexes can trigger specific, T cell-dependent, autoanti-IgG antibody production in mice by NEMAZEE, D. A

“…Immunization of mice with a combination of passively administered syngeneic IgG (anti-p-azophenylarsonate [anti-Ars]) antibody and a soluble, multivalent form…”
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Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells by Huang, Deli, Tran, Jenny Tuyet, Olson, Alex, Vollbrecht, Thomas, Tenuta, Mary, Guryleva, Mariia V., Fuller, Roberta P., Schiffner, Torben, Abadejos, Justin R., Couvrette, Lauren, Blane, Tanya R., Saye, Karen, Li, Wenjuan, Landais, Elise, Gonzalez-Martin, Alicia, Schief, William, Murrell, Ben, Burton, Dennis R., Nemazee, David, Voss, James E.

“…HIV broadly neutralizing antibodies (bnAbs) can suppress viremia and protect against HIV infection. However, their elicitation is made difficult by low…”
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Revising B cell receptors by Nemazee, D, Weigert, M

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Reprogramming the antigen specificity of B cells using genome-editing technologies by Voss, James E, Gonzalez-Martin, Alicia, Andrabi, Raiees, Fuller, Roberta P, Murrell, Ben, McCoy, Laura E, Porter, Katelyn, Huang, Deli, Li, Wenjuan, Sok, Devin, Le, Khoa, Briney, Bryan, Chateau, Morgan, Rogers, Geoffrey, Hangartner, Lars, Feeney, Ann J, Nemazee, David, Cannon, Paula, Burton, Dennis R

“…We have developed a method to introduce novel paratopes into the human antibody repertoire by modifying the immunoglobulin (Ig) genes of mature B cells…”
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Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors): a structural explanation for the high frequency of IgM anti-IgG B cells by SHLOMCHIK, M. J, NEMAZEE, D. A, SATO, V. L, VAN SNICK, J, CARSON, D. A, WEIGERT, M. G

“…The nucleotide sequences of heavy and light chains from 10 monoclonal IgM anti-IgG1 (RF) antibodies were determined and reported here as translated amino acid…”
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Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response by NEMAZEE, D. A, SATO, V. L

“…A/J mice were found to produce autoreactive IgM anti-IgG1 in response to secondary immunization with a number of protein antigens. No anti-IgG1 was produced…”
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