Search Results - "Nelson, Ruth S"

The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases by Nelson, Peter T, Abner, Erin L, Patel, Ela, Anderson, Sonya, Wilcock, Donna M, Kryscio, Richard J, Van Eldik, Linda J, Jicha, Gregory A, Gal, Zsombor, Nelson, Ruth S, Nelson, Bela G, Gal, Jozsef, Azam, Md. Tofial, Fardo, David W, Cykowski, Matthew D

“…Abstract Over the course of most common neurodegenerative diseases the amygdala accumulates pathologically misfolded proteins. Misfolding of 1 protein in aged…”
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Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain by Rayaprolu, Sruti, Bitarafan, Sara, Santiago, Juliet V., Betarbet, Ranjita, Sunna, Sydney, Cheng, Lihong, Xiao, Hailian, Nelson, Ruth S., Kumar, Prateek, Bagchi, Pritha, Duong, Duc M., Goettemoeller, Annie M., Oláh, Viktor János, Rowan, Matt, Levey, Allan I., Wood, Levi B., Seyfried, Nicholas T., Rangaraju, Srikant

“…Proteomic profiling of brain cell types using isolation-based strategies pose limitations in resolving cellular phenotypes representative of their native…”
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Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology by Kumar, Prateek, Goettemoeller, Annie M., Espinosa-Garcia, Claudia, Tobin, Brendan R., Tfaily, Ali, Nelson, Ruth S., Natu, Aditya, Dammer, Eric B., Santiago, Juliet V., Malepati, Sneha, Cheng, Lihong, Xiao, Hailian, Duong, Duc D., Seyfried, Nicholas T., Wood, Levi B., Rowan, Matthew J. M., Rangaraju, Srikant

“…Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining…”
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Brain Cell Type-Specific Nuclear Proteomics Is Imperative to Resolve Neurodegenerative Disease Mechanisms by Nelson, Ruth S, Dammer, Eric B, Santiago, Juliet V, Seyfried, Nicholas T, Rangaraju, Srikant

“…Neurodegenerative diseases (NDs) involve complex cellular mechanisms that are incompletely understood. Emerging findings have revealed that disruption of…”
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Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort by Nelson, Ruth S, Abner, Erin L, Jicha, Gregory A, Schmitt, Frederick A, Di, Jing, Wilcock, Donna M, Barber, Justin M, Van Eldik, Linda J, Katsumata, Yuriko, Fardo, David W, Nelson, Peter T

“…In addition to the memory disorders and global cognitive impairment that accompany neurodegenerative diseases, behavioral and psychological symptoms of…”
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A neuropathologic feature of brain aging: multi-lumen vascular profiles by Ighodaro, Eseosa T, Shahidehpour, Ryan K, Bachstetter, Adam D, Abner, Erin L, Nelson, Ruth S, Fardo, David W, Shih, Andy Y, Grant, Roger I, Neltner, Janna H, Schmitt, Frederick A, Jicha, Gregory A, Kryscio, Richard J, Wilcock, Donna M, Van Eldik, Linda J, Nelson, Peter T

“…Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs), which are…”
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Urinary Incontinence in a Community-Based Autopsy Cohort Is Associated with Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Changes by Di, Jing, Nelson, Ruth S, Jicha, Gregory A, Moga, Daniela C, Barber, Justin M, Cykowski, Matthew D, Fardo, David W, Abner, Erin L, Nelson, Peter T

“…Dementia and urinary incontinence (UI) are etiologically complex clinical syndromes. Dementia and UI often occur in the same individuals, but underlying…”
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Exploratory Mass Spectrometry of Cerebrospinal Fluid from Persons with Autopsy-Confirmed LATE-NC by Gal, Jozsef, Vary, Calvin, Gartner, Carlos A., Jicha, Gregory A., Abner, Erin L., Ortega, Yulica S., Choucair, Ibrahim, Wilcock, Donna M., Nelson, Ruth S., Nelson, Peter T.

“…Common neuropathologies associated with dementia include Alzheimer’s disease neuropathologic change (ADNC) and limbic-predominant age-related TDP-43…”
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Age‐Dependent Changes in Perineuronal Nets and Associated Parvalbumin Interneurons in the 5xFAD Amyloidosis Mouse Model by Nelson, Ruth S, Rangaraju, Srikant, Rayaprolu, Sruti, Kumar, Prateek, Espinosa‐Garcia, Claudia, Xiao, Hailian

“…Background Perineuronal nets (PNNs) are extracellular matrix structures that surround neurons and proximal dendrites and regulate synaptic transmission,…”
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In vivo TurboID proximity labeling to capture astrocyte proteomic and transcriptomic signatures under homeostatic and neuroinflammatory conditions by Ramelow, Christina C, Sunna, Sydney N, Rayaprolu, Sruti, Nelson, Ruth S, Sampson, Maureen, Xiao, Hailian, Cheng, Lihong, Kumar, Prateek, Seyfried, Nicholas T, Sloan, Steven A, Rangaraju, Srikant

“…Background Despite decades of research into the cellular and molecular contributions of brain cell types to Alzheimer’s disease (AD) pathogenesis, there are no…”
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