Search Results - "Nelson, Peter J."

Lipid metabolism in cancer progression and therapeutic strategies by Fu, Yan, Zou, Tiantian, Shen, Xiaotian, Nelson, Peter J., Li, Jiahui, Wu, Chao, Yang, Jimeng, Zheng, Yan, Bruns, Christiane, Zhao, Yue, Qin, Lunxiu, Dong, Qiongzhu

“…Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, cholesterol, and phospholipid are the three most prevalent…”
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Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation by Sun, Jialei, Zhou, Chenhao, Zhao, Yue, Zhang, Xiaofei, Chen, Wanyong, Zhou, Qiang, Hu, Bo, Gao, Dongmei, Raatz, Lisa, Wang, Zhefang, Nelson, Peter J., Jiang, Yuchao, Ren, Ning, Bruns, Christiane J., Zhou, Haijun

“…Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), but its clinical effects are still limited. In this study we…”
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Therapeutic Strategies Targeting Cancer Stem Cells and Their Microenvironment by Sun, Hao-Ran, Wang, Shun, Yan, Shi-Can, Zhang, Yu, Nelson, Peter J., Jia, Hu-Liang, Qin, Lun-Xiu, Dong, Qiong-Zhu

“…Cancer stem cells (CSCs) have been demonstrated in a variety of tumors and are thought to act as a clonogenic core for the genesis of new tumor growth. This…”
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Sodium storage in human tissues is mediated by glycosaminoglycan expression by Fischereder, Michael, Michalke, Bernhard, Schmöckel, Elisa, Habicht, Antje, Kunisch, Raphael, Pavelic, Ivana, Szabados, Bernadette, Schönermarck, Ulf, Nelson, Peter J, Stangl, Manfred

“…The current paradigm regarding sodium handling in animals and humans postulates that total body sodium is regulated predominately via regulation of…”
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Current diagnostics and treatment of fibrosarcoma -perspectives for future therapeutic targets and strategies by Augsburger, Daniela, Nelson, Peter J, Kalinski, Thomas, Udelnow, Andrej, Knösel, Thomas, Hofstetter, Monika, Qin, Ji Wei, Wang, Yan, Gupta, Arvid Sen, Bonifatius, Susanne, Li, Minglun, Bruns, Christiane J, Zhao, Yue

“…Adult-type fibrosarcoma is a rare and highly aggressive subtype of soft tissue sarcomas. Due to the existence of other spindle-cell shaped sarcomas, its…”
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A molecular morphometric approach to diabetic kidney disease can link structure to function and outcome by Nair, Viji, Komorowsky, Claudiu V, Weil, E Jennifer, Yee, Berne, Hodgin, Jeffrey, Harder, Jennifer L, Godfrey, Bradley, Ju, Wenjun, Boustany-Kari, Carine M, Schwarz, Margrit, Lemley, Kevin V, Nelson, Peter J, Nelson, Robert G, Kretzler, Matthias

“…Diabetic kidney disease is the leading cause of kidney failure. However, studies of molecular mechanisms of early kidney damage are lacking. Here we examined…”
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Editorial: Cancer Cell Metabolism and Immunomodulation in the Context of Tumor Metastasis by Dong, Qiongzhu, Nelson, Peter J, Zhao, Yue

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Regional Hyperthermia Enhances Mesenchymal Stem Cell Recruitment to Tumor Stroma: Implications for Mesenchymal Stem Cell-Based Tumor Therapy by Tutter, Mariella, Schug, Christina, Schmohl, Kathrin A., Urnauer, Sarah, Kitzberger, Carolin, Schwenk, Nathalie, Petrini, Matteo, Zach, Christian, Ziegler, Sibylle, Bartenstein, Peter, Weber, Wolfgang A., Multhoff, Gabriele, Wagner, Ernst, Lindner, Lars H., Nelson, Peter J., Spitzweg, Christine

“…The tropism of mesenchymal stem cells (MSCs) for tumors forms the basis for their use as delivery vehicles for the tumor-specific transport of therapeutic…”
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Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer by Wang, Zhefang, Qin, Jie, Zhao, Jiangang, Li, Jiahui, Li, Dai, Popp, Marie, Popp, Felix, Alakus, Hakan, Kong, Bo, Dong, Qiongzhu, Nelson, Peter J, Zhao, Yue, Bruns, Christiane J

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide and effective therapy remains a challenge. IFIT3 is an…”
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Selective Targeting of Genetically Engineered Mesenchymal Stem Cells to Tumor Stroma Microenvironments Using Tissue-Specific Suicide Gene Expression Suppresses Growth of Hepatocellular Carcinoma by NIESS, Hanno, QI BAO, BRUNS, Christiane J, CONRAD, Claudius, ZISCHEK, Christoph, NOTOHAMIPRODJO, Mike, SCHWAB, Felix, SCHWARZ, Bettina, HUSS, Ralf, JAUCH, Karl-Walter, NELSON, Peter J

“…The use of engineered mesenchymal stem cells (MSCs) as therapeutic vehicles for the treatment of experimental pancreatic and breast cancer has been previously…”
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Concise Review: Genetically Engineered Stem Cell Therapy Targeting Angiogenesis and Tumor Stroma in Gastrointestinal Malignancy by Keung, Emily Z., Nelson, Peter J., Conrad, Claudius

“…Cell‐based gene therapy holds considerable promise for the treatment of human malignancy. Genetically engineered cells if delivered to sites of disease could…”
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Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer by Zheng, Yan, Wu, Chao, Yang, Jimeng, Zhao, Yue, Jia, Huliang, Xue, Min, Xu, Da, Yang, Feng, Fu, Deliang, Wang, Chaoqun, Hu, Beiyuan, Zhang, Ze, Li, Tianen, Yan, Shican, Wang, Xuan, Nelson, Peter J., Bruns, Christiane, Qin, Lunxiu, Dong, Qiongzhu

“…Enolase 2 (ENO2) is a key glycolytic enzyme in the metabolic process of glycolysis, but its potential function in pancreatic ductal adenocarcinoma (PDAC) is…”
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No NLRP3 inflammasome activity in kidney epithelial cells, not even when the NLRP3-A350V Muckle-Wells variant is expressed in podocytes of diabetic mice by Kunte, Sophie Carina, Marschner, Julian A., Klaus, Martin, Honda, Tâmisa, Li, Chenyu, Motrapu, Manga, Walz, Christoph, Angelotti, Maria Lucia, Antonelli, Giulia, Melica, Maria Elena, De Chiara, Letizia, Semeraro, Roberto, Nelson, Peter J., Anders, Hans-Joachim

“…Background The NLRP3 inflammasome integrates several danger signals into the activation of innate immunity and inflammation by secreting IL-1β and IL-18. Most…”
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Modular Activation of Nuclear Factor-κB Transcriptional Programs in Human Diabetic Nephropathy by SCHMID, Holger, BOUCHEROT, Anissa, NELSON, Peter J, SCHLÖNDORFF, Detlef, COHEN, Clemens D, KRETZLER, Matthias, YASUDA, Yoshinari, HENGER, Anna, BRUNNER, Bodo, EICHINGER, Felix, NITSCHE, Almut, KISS, Eva, BLEICH, Markus, GRÖNE, Hermann-Josef

“…Modular Activation of Nuclear Factor-κB Transcriptional Programs in Human Diabetic Nephropathy Holger Schmid 1 , Anissa Boucherot 1 , Yoshinari Yasuda 1 , Anna…”
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The hormetic functions of Wnt pathways in tubular injury by Gröne, Elisabeth F., Federico, Giuseppina, Nelson, Peter J., Arnold, Bernd, Gröne, Hermann-Josef

“…Chronic tubulointerstitial damage with tubular epithelial atrophy and interstitial fibrosis is the hallmark of chronic kidney disease (CKD) and a predictor for…”
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Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide by Siegert, Stefanie, Huang, Hsin-Ying, Yang, Chen-Ying, Scarpellino, Leonardo, Carrie, Lucie, Essex, Sarah, Nelson, Peter J, Heikenwalder, Matthias, Acha-Orbea, Hans, Buckley, Christopher D, Marsland, Benjamin J, Zehn, Dietmar, Luther, Sanjiv A

“…Adaptive immune responses are initiated when T cells encounter antigen on dendritic cells (DC) in T zones of secondary lymphoid organs. T zones contain a…”
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Antisense inhibition of microRNA-21 and microRNA-221 in tumor-initiating stem-like cells modulates tumorigenesis, metastasis, and chemotherapy resistance in pancreatic cancer by Zhao, Yue, Zhao, Lu, Ischenko, Ivan, Bao, Qi, Schwarz, Bettina, Nieß, Hanno, Wang, Yan, Renner, Andrea, Mysliwietz, Josef, Jauch, Karl-Walter, Nelson, Peter J., Ellwart, Joachim W., Bruns, Christiane J., Camaj, Peter

“…Our preliminary studies identified a small population side population (SP) cells in pancreatic cancer cells with stem cell-like properties, which were able to…”
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Multipotent Mesenchymal Stem Cells Acquire a Lymphendothelial Phenotype and Enhance Lymphatic Regeneration In Vivo by CONRAD, Claudius, NIESS, Hanno, HUSS, Ralf, HUBER, Stephan, VON LUETTICHAU, Irene, NELSON, Peter J, OTT, Harald C, JAUCH, Karl-Walter, BRUNS, Christiane J

“…The importance and therapeutic value of stem cells in lymphangiogenesis are poorly understood. We evaluated the potential of human and murine mesenchymal stem…”
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Successive Release of Tissue Inhibitors of Metalloproteinase-1 Through Graphene Oxide-Based Delivery System Can Promote Skin Regeneration by Zhong, Cheng, Shi, Dike, Zheng, Yixiong, Nelson, Peter J., Bao, Qi

“…The purpose of this study was to testify the hypothesis that graphene oxide (GO) could act as an appropriate vehicle for the release of tissue inhibitors of…”
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The sodium iodide symporter (NIS) as theranostic gene: its emerging role in new imaging modalities and non-viral gene therapy by Kitzberger, Carolin, Spellerberg, Rebekka, Morath, Volker, Schwenk, Nathalie, Schmohl, Kathrin A., Schug, Christina, Urnauer, Sarah, Tutter, Mariella, Eiber, Matthias, Schilling, Franz, Weber, Wolfgang A., Ziegler, Sibylle, Bartenstein, Peter, Wagner, Ernst, Nelson, Peter J., Spitzweg, Christine

“…Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies…”
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