Search Results - "Nelson, Laura D"

Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer by Mudduluru, Giridhar, George-William, Jonahunnatha N, Muppala, Santoshi, Asangani, Irfan A, Kumarswamy, Regalla, Nelson, Laura D, Allgayer, Heike

“…Curcumin has promising potential in cancer prevention and therapy by interacting with proteins and modifying their expression and activity, which includes…”
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Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer by Nelson, Laura D, Bender, Christian, Mannsperger, Heiko, Buergy, Daniel, Kambakamba, Patryk, Mudduluru, Giridhar, Korf, Ulrike, Hughes, Dennis, Van Dyke, Michael W, Allgayer, Heike

“…Tri- and tetra-nucleotide repeats in mammalian genomes can induce formation of alternative non-B DNA structures such as triplexes and guanine (G)-quadruplexes…”
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Small molecule ErbB inhibitors decrease proliferative signaling and promote apoptosis in philadelphia chromosome-positive acute lymphoblastic leukemia by Irwin, Mary E, Nelson, Laura D, Santiago-O'Farrill, Janice M, Knouse, Phillip D, Miller, Claudia P, Palla, Shana L, Siwak, Doris R, Mills, Gordon B, Estrov, Zeev, Li, Shulin, Kornblau, Steven M, Hughes, Dennis P, Chandra, Joya

“…The presence of the Philadelphia chromosome in patients with acute lymphoblastic leukemia (Ph(+)ALL) is a negative prognostic indicator. Tyrosine kinase…”
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Correction to “Improving Paclitaxel Delivery: In Vitro and In Vivo Characterization of PEGylated Polyphosphoester-Based Nanocarriers” by Zhang, Fuwu, Zhang, Shiyi, Pollack, Stephanie F, Li, Richen, Gonzalez, Amelia M, Fan, Jingwei, Zou, Jiong, Leininger, Sarah E, Pavía-Sanders, Adriana, Johnson, Rachel, Nelson, Laura D, Raymond, Jeffery E, Elsabahy, Mahmoud, Hughes, Dennis M. P, Lenox, Mark W, Gustafson, Tiffany P, Wooley, Karen L

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The acyltransferase Gpc1 is both a target and an effector of the unfolded protein response in Saccharomyces cerevisiae by Hrach, Victoria Lee, King, William R., Nelson, Laura D., Conklin, Shane, Pollock, John A., Patton-Vogt, Jana

“…The unfolded protein response (UPR) is sensitive to proteotoxic and membrane bilayer stress, both of which are sensed by the ER protein Ire1. When activated,…”
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Improving Paclitaxel Delivery: In Vitro and In Vivo Characterization of PEGylated Polyphosphoester-Based Nanocarriers by Zhang, Fuwu, Zhang, Shiyi, Pollack, Stephanie F, Li, Richen, Gonzalez, Amelia M, Fan, Jingwei, Zou, Jiong, Leininger, Sarah E, Pavía-Sanders, Adriana, Johnson, Rachel, Nelson, Laura D, Raymond, Jeffery E, Elsabahy, Mahmoud, Hughes, Dennis M. P, Lenox, Mark W, Gustafson, Tiffany P, Wooley, Karen L

“…Nanomaterials have great potential to offer effective treatment against devastating diseases by providing sustained release of high concentrations of…”
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Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia by Hecht, Jacqueline T, Nelson, Laura D, Crowder, Eric, Wang, Yang, Elder, Frederick F.B, Harrison, Wilbur R, Francomano, Clair A, Prange, Christa K, Lennon, Gregory G, Deere, Michelle, Lawler, Jack

“…Pseudoachondroplasia (PSACH) is a well characterized dwarfing condition mapping to chromosome 19p12-13.1. Cartilage oligomeric matrix protein (COMP), a…”
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Unraveling the role of FOXQ1 in colorectal cancer metastasis by Abba, Mohammed, Patil, Nitin, Rasheed, Kabeer, Nelson, Laura D, Mudduluru, Giridhar, Leupold, Jörg Hendrik, Allgayer, Heike

“…Malignant cell transformation, invasion, and metastasis are dependent on the coordinated rewiring of gene expression. A major component in the scaffold of…”
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Characterization of Purine-Motif Triplex DNA-Binding Proteins in HeLa Extracts by Musso, Marco, Nelson, Laura D, Van Dyke, Michael W

“…One piece of evidence indicating that triple-helical DNAs exist in vivo would be the demonstration of cellular proteins that recognize such structures. Using…”
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Cetuximab Attenuates Metastasis and u-PAR Expression in Non-Small Cell Lung Cancer: u-PAR and E-Cadherin are Novel Biomarkers of Cetuximab Sensitivity by NIKOLOVA, Dessislava A, ASANGANI, Irfan A, ALLGAYER, Heike, NELSON, Laura D, HUGHES, Dennis P. M, SIWAK, Doris R, MILLS, Gordon B, HARMS, Andrea, BUCHHOLZ, Erika, PILZ, Lothar R, MANEGOLD, Christian

“…Cetuximab, which blocks ligand binding to epidermal growth factor receptor (EGFR), is currently being studied as a novel treatment for non-small cell lung…”
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Stm1p, a G4 quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y' DNA in Saccharomyces cerevisiae by Van Dyke, Michael W, Nelson, Laura D, Weilbaecher, Rodney G, Mehta, Dakshesh V

“…The Saccharomyces cerevisiae protein Stm1 was originally identified as a G4 quadruplex and purine motif triplex nucleic acid-binding protein. However, more…”
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The Yeast STM1 Gene Encodes a Purine Motif Triple Helical DNA-binding Protein by Nelson, Laura D., Musso, Marco, Van Dyke, Michael W.

“…The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination. Using conventional…”
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Fundulus heteroclitus vitellogenin: the deduced primary structure of a piscine precursor to noncrystalline, liquid-phase yolk protein by LaFleur, Jr, G J, Byrne, B M, Kanungo, J, Nelson, L D, Greenberg, R M, Wallace, R A

“…We have cloned and sequenced a cDNA encoding a vitellogenin (Vtg) from the mummichog, Fundulus heteroclitus, an estuarine teleost. We constructed a liver cDNA…”
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Ingested IFN-alpha has biological effects in humans with relapsing-remitting multiple sclerosis by Brod, S A, Kerman, R H, Nelson, L D, Marshall, Jr, G D, Henninger, E M, Khan, M, Jin, R, Wolinsky, J S

“…Parenterally administered human recombinant type I interferons (hrIFN) in relapsing-remitting multiple sclerosis (RRMS) decrease relapses and spontaneous in…”
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Abstract 3970: EGF has stimulatory and survival effects in osteosarcoma in vitro and pan-ERBB kinase inhibition causes cell growth inhibition in vitro and reduces lung metastases in vivo by Nelson, Laura D., Lynch, Tiffany N., Yang, Yanwen, Wang, Wei-Lien, Liu, Diane, Thomas, Dafydd G., Hughes, Dennis P. M.

“…Abstract Osteosarcoma is the most common primary bone tumor in children and adolescents, with recurring disease or lung metastases being the primary cause of…”
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Abstract 2703: A direct regulation of Twist1 by FOXQ1 promotes colorectal cancer metastasis by Abba, Mohammed, Patil, Nitin, Rasheed, Kabeer, Nelson, Laura D., Mudduluru, Giridhar, Leupold, Jörg H., Allgayer, Heike

“…Abstract Abstract Malignant cell transformation, invasion and metastasis are dependent on the coordinated rewiring of gene expression. A major component in the…”
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Abstract 1043: Role of protein kinase Cι in alveolar rhabdomyosarcoma by Kikuchi, Ken, Soundararajan, Anuradha, Zarzabal, Lee Ann, Weems, Capella R., Nelson, Laura D., Hampton, Sheila T., Michalek, Joel A., Rubin, Brian P., Fields, Alan P., Keller, Charles

“…Abstract Background: Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer showing skeletal muscle differentiation. New therapeutic targets are…”
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Abstract 4566: Triplex DNA-binding proteins in resected normal and tumor tissues from colorectal cancer patients: Biological and clinical relevance by Nelson, Laura D., Mannsperger, Heiko, Bender, Christian, Buergy, Daniel, Kambakamba, Patryk, Mudduluru, Giridhar, Hughes, Dennis P., Van Dyke, Michael W., Allgayer, Heike

“…Abstract This study is to determine if triplex DNA-binding proteins in human cells play an important role in processes that lead to cancer such as genetic…”
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ERBB Signaling Promotes BCR-Abl Expression and Modulates Multiple Signaling Pathways as Assessed by High-Throughput, Reverse Phase Protein Array by Nelson, Laura D., Siwak, Doris R., Lu, Yiling, Miller, Claudia, Chandra, Joya, Hughes, Dennis P.M.

“…ERBB family receptor tyrosine kinases, EGFR, Her-2, Her-3 and Her-4, are prognostic and therapeutic targets in multiple carcinomas, including breast, lung, and…”
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Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. e70608 by Irwin, Mary E, Nelson, Laura D, Santiago-O'Farrill, Janice M, Knouse, Phillip D, Miller, Claudia P, Palla, Shana L, Siwak, Doris R, Mills, Gordon B, Estrov, Zeev, Li, Shulin

“…The presence of the Philadelphia chromosome in patients with acute lymphoblastic leukemia (Ph+ALL) is a negative prognostic indicator. Tyrosine kinase…”
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