Search Results - "Nelson, Jonathan W"

The START App: a web-based RNAseq analysis and visualization resource by Nelson, Jonathan W, Sklenar, Jiri, Barnes, Anthony P, Minnier, Jessica

“…Transcriptional profiling using RNA sequencing (RNAseq) has emerged as a powerful methodology to quantify global gene expression patterns in various contexts…”
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Renal-Tubule Epithelial Cell Nomenclature for Single-Cell RNA-Sequencing Studies by Chen, Lihe, Clark, Jevin Z, Nelson, Jonathan W, Kaissling, Brigitte, Ellison, David H, Knepper, Mark A

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Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway by Cornelius, Ryan J, Si, Jinge, Cuevas, Catherina A, Nelson, Jonathan W, Gratreak, Brittany D K, Pardi, Ruggero, Yang, Chao-Ling, Ellison, David H

“…The familial hyperkalemic hypertension (FHHt) cullin 3 (CUL3) mutant does not degrade WNK kinases normally, thereby leading to thiazide-sensitive Na-Cl…”
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Remyelination protects neurons from DLK-mediated neurodegeneration by Duncan, Greg J., Ingram, Sam D., Emberley, Katie, Hill, Jo, Cordano, Christian, Abdelhak, Ahmed, McCane, Michael, Jenks, Jennifer E., Jabassini, Nora, Ananth, Kirtana, Ferrara, Skylar J., Stedelin, Brittany, Sivyer, Benjamin, Aicher, Sue A., Scanlan, Thomas S., Watkins, Trent A., Mishra, Anusha, Nelson, Jonathan W., Green, Ari J., Emery, Ben

“…Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the degeneration of neurons and their connections that drives…”
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Angiotensin II Directly Increases Endothelial Calcium and Nitric Oxide in Kidney and Brain Microvessels In Vivo With Reduced Efficacy in Hypertension by Becerra Calderon, Alejandra, Shroff, Urvi Nikhil, Deepak, Sachin, Izuhara, Audrey, Trogen, Greta, McDonough, Alicia A, Gurley, Susan B, Nelson, Jonathan W, Peti-Peterdi, János, Gyarmati, Georgina

“…The vasoconstrictor effects of angiotensin II via type 1 angiotensin II receptors in vascular smooth muscle cells are well established, but the direct effects…”
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Disrupting Dimerization Translocates Soluble Epoxide Hydrolase to Peroxisomes by Nelson, Jonathan W, Das, Anjali J, Barnes, Anthony P, Alkayed, Nabil J

“…The epoxyeicosatrienoic acid (EET) neutralizing enzyme soluble epoxide hydrolase (sEH) is a neuronal enzyme, which has been localized in both the cytosol and…”
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GPR39 localization in the aging human brain and correlation of expression and polymorphism with vascular cognitive impairment by Davis, Catherine M., Bah, Thierno M., Zhang, Wenri H., Nelson, Jonathan W., Golgotiu, Kirsti, Nie, Xiao, Alkayed, Farah N., Young, Jennifer M., Woltjer, Randy L., Silbert, Lisa C., Grafe, Marjorie R., Alkayed, Nabil J.

“…Introduction The pathogenesis of vascular cognitive impairment (VCI) is not fully understood. GPR39, an orphan G‐protein coupled receptor, is implicated in…”
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Advances in use of mouse models to study the renin-angiotensin system by Emathinger, Jacqueline M., Nelson, Jonathan W., Gurley, Susan B.

“…The renin-angiotensin system (RAS) is a highly complex hormonal cascade that spans multiple organs and cell types to regulate solute and fluid balance along…”
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Control of coronary vascular resistance by eicosanoids via a novel GPCR by Alkayed, Nabil J, Cao, Zhiping, Qian, Zu Yuan, Nagarajan, Shanthi, Liu, Xuehong, Nelson, Jonathan W, Xie, Fuchun, Li, Bingbing, Fan, Wei, Liu, Lijuan, Grafe, Marjorie R, Davis, Catherine M, Xiao, Xiangshu, Barnes, Anthony P, Kaul, Sanjiv

“…Arachidonic acid metabolites epoxyeicosatrienoates (EETs) and hydroxyeicosatetraenoates (HETEs) are important regulators of myocardial blood flow and coronary…”
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COP9 signalosome deletion promotes renal injury and distal convoluted tubule remodeling by Cornelius, Ryan J, Nelson, Jonathan W, Su, Xiao-Tong, Yang, Chao-Ling, Ellison, David H

“…Cullin-RING ligases are a family of E3 ubiquitin ligases that control cellular processes through regulated degradation. Cullin 3 targets with-no-lysine kinase…”
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Age-dependent transcriptional alterations in cardiac endothelial cells by Emechebe, Uchenna, Nelson, Jonathan W, Alkayed, Nabil J, Kaul, Sanjiv, Adey, Andrew C, Barnes, Anthony P

“…Aging is a significant risk factor for cardiovascular disease. Despite the fact that endothelial cells play critical roles in cardiovascular function and…”
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Role of adenosine signaling in coordinating cardiomyocyte function and coronary vascular growth in chronic fetal anemia by Davis, Lowell, Musso, James, Soman, Divya, Louey, Samantha, Nelson, Jonathan W, Jonker, Sonnet S

“…Fetal anemia causes rapid and profound changes in cardiac structure and function, stimulating proliferation of the cardiac myocytes, expansion of the coronary…”
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Cullin-Ring ubiquitin ligases in kidney health and disease by Cornelius, Ryan J, Ferdaus, Mohammed Z, Nelson, Jonathan W, McCormick, James A

“…PURPOSE OF REVIEWMembers of the Cullin family act as scaffolds in E3 ubiquitin ligases and play a central role in mediating protein degradation. Interactions…”
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Machine Learning Illuminates the Extraglomerular Microvasculature by Kung, Vanderlene L, Nelson, Jonathan W

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Local and downstream actions of proximal tubule angiotensin II signaling on Na + transporters in the mouse nephron by Nelson, Jonathan W, McDonough, Alicia A, Xiang, Zhidan, Ralph, Donna L, Robertson, Joshua A, Giani, Jorge F, Bernstein, Kenneth E, Gurley, Susan B

“…The renal nephron consists of a series of distinct cell types that function in concert to maintain fluid and electrolyte balance and blood pressure. The…”
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Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation After Subarachnoid Hemorrhage by Siler, Dominic A, Berlow, Yosef A, Kukino, Ayaka, Davis, Catherine M, Nelson, Jonathan W, Grafe, Marjorie R, Ono, Hirohisa, Cetas, Justin S, Pike, Martin, Alkayed, Nabil J

“…BACKGROUND AND PURPOSE—Acute communicating hydrocephalus and cerebral edema are common and serious complications of subarachnoid hemorrhage (SAH), whose causes…”
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Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid by Liu, Xuehong, Qian, Zu-yuan, Xie, Fuchun, Fan, Wei, Nelson, Jonathan W., Xiao, Xiangshu, Kaul, Sanjiv, Barnes, Anthony P., Alkayed, Nabil J.

“…Epoxyeicosatrienoic acids (EETs) are potent vasodilators that play important roles in cardiovascular physiology and disease, yet the molecular mechanisms…”
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Salt-sensitive transcriptome of isolated kidney distal tubule cells by Swanson, Elizabeth A, Nelson, Jonathan W, Jeng, Sophia, Erspamer, Kayla J, Yang, Chao-Ling, McWeeney, Shannon, Ellison, David H

“…In the distal kidney tubule, the steroid hormone aldosterone regulates sodium reabsorption via the epithelial sodium channel (ENaC). Most studies seeking to…”
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Peroxisomal Translocation of Soluble Epoxide Hydrolase Protects against Ischemic Stroke Injury by Nelson, Jonathan W, Zhang, Wenri, Alkayed, Nabil J, Koerner, Ines P

“…Soluble epoxide hydrolase (sEH) contributes to cardiovascular disease, including stroke, although the exact mechanism remains unclear. While primarily a…”
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Endothelial transcriptomics reveals activation of fibrosis-related pathways in hypertension by Nelson, Jonathan W, Ferdaus, Mohammed Z, McCormick, James A, Minnier, Jessica, Kaul, Sanjiv, Ellison, David H, Barnes, Anthony P

“…Hypertension poses a significant challenge to vasculature homeostasis and stands as the most common cardiovascular disease in the world. Its effects are…”
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