Search Results - "Nelson, J. Luke"
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Molecular assays for the detection of microRNAs in prostate cancer
Published in Molecular cancer (06-03-2009)“…MicroRNAs (miRNAs) are small non-coding RNAs (about 21 to 24 nucleotides in length) that effectively reduce the translation of their target mRNAs. Several…”
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Journal Article -
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What Is the Effect of COVID-19-Related Social Distancing on Oral and Maxillofacial Trauma?
Published in Journal of oral and maxillofacial surgery (01-05-2021)“…The purpose of this study was to understand the impact of social distancing policies enacted during the COVID-19 pandemic on the epidemiology of oral and…”
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Journal Article -
3
Ultrasonic Analytic-Signal Responses From Polymer-Matrix Composite Laminates
Published in IEEE transactions on ultrasonics, ferroelectrics, and frequency control (01-02-2018)“…Ultrasound has been used to inspect composite laminates since their invention but only recently has the response from the internal plies themselves been…”
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Journal Article -
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Src Kinase Is Biphosphorylated at Y416/Y527 and Activates the CUB-Domain Containing Protein 1/Protein Kinase C δ Pathway in a Subset of Triple-Negative Breast Cancers
Published in The American journal of pathology (01-02-2020)“…Targeted therapeutics are needed for triple-negative breast cancer (TNBC). In this study, we investigated the activation of Src family of cytoplasmic tyrosine…”
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Odontogenic Infections: Disease Burden During COVID-19 at a Single Institution
Published in Journal of oral and maxillofacial surgery (01-04-2021)“…The purpose of this study was to document the effect of coronavirus disease 2019 (COVID-19) on patients presenting to the University of Washington Oral and…”
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Synthetic lethality of cyclin-dependent kinase inhibitor Dinaciclib with VHL-deficiency allows for selective targeting of clear cell renal cell carcinoma
Published in Cell cycle (Georgetown, Tex.) (19-05-2022)“…Clear cell renal cell carcinoma (CC-RCC) remains one of the most deadly forms of kidney cancer despite recent advancements in targeted therapeutics, including…”
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Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism
Published in Molecular cancer therapeutics (01-08-2018)“…Clear cell renal cell carcinoma (CC-RCC) is a devastating disease with limited therapeutic options available for advanced stages. The objective of this study…”
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Abstract 6395: VHL deficiency sensitizes CC-RCC to inhibition of small GTPases by statins
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Clear cell renal cell carcinoma (CC-RCC) type of kidney cancer has limited therapeutic options available for advanced stages. The objective of this study was…”
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Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma
Published in Oncogene (23-02-2017)“…Clear cell renal cell carcinoma (CC-RCC) is the most lethal of all genitourinary cancers. The functional loss of the von Hippel-Lindau ( VHL ) gene occurs in…”
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Journal Article -
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Abstract PR15: Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma
Published in Molecular cancer therapeutics (01-10-2017)“…Clear cell renal cell carcinoma (CC-RCC) is the most lethal of all genitourinary cancers. The functional loss of the von Hippel-Lindau (VHL) gene occurs in 90%…”
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Characterisation and modelling of active fibre composites
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Dissertation -
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Characterisation and modelling of active fibre composites
Published 01-01-2005“…The objective of this study is to examine the major components of a newly developed active composite configuration, and to use the understanding gained to…”
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Dissertation