Search Results - "Nelson, Dusetti J."

Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development by Gironella, Meritxell, Seux, Mylène, Xie, Min-Jue, Cano, Carla, Tomasini, Richard, Gommeaux, Julien, Garcia, Stephane, Nowak, Jonathan, Yeung, Man Lung, Jeang, Kuan-Teh, Chaix, Amandine, Fazli, Ladan, Motoo, Yoshiharu, Wang, Qing, Rocchi, Palma, Russo, Antonio, Gleave, Martin, Dagorn, Jean-Charles, Iovanna, Juan L, Carrier, Alice, Pébusque, Marie-Josèphe, Dusetti, Nelson J

“…Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a proapoptotic stress-induced p53…”
Get full text

TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma by Ng, Kai-Yu, Chan, Lok-Hei, Chai, Stella, Tong, Man, Guan, Xin-Yuan, Lee, Nikki P, Yuan, Yunfei, Xie, Dan, Lee, Terence K, Dusetti, Nelson J, Carrier, Alice, Ma, Stephanie

“…Identifying critical factors involved in the metastatic progression of hepatocellular carcinoma (HCC) may offer important therapeutic opportunities. Here, we…”
Get full text

Copy Number Gain of hsa-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers by Chaluvally-Raghavan, Pradeep, Zhang, Fan, Pradeep, Sunila, Hamilton, Mark P., Zhao, Xi, Rupaimoole, Rajesha, Moss, Tyler, Lu, Yiling, Yu, Shuangxing, Pecot, Chad V., Aure, Miriam R., Peuget, Sylvain, Rodriguez-Aguayo, Cristian, Han, Hee-Dong, Zhang, Dong, Venkatanarayan, Avinashnarayan, Krohn, Marit, Kristensen, Vessela N., Gagea, Mihai, Ram, Prahlad, Liu, Wenbin, Lopez-Berestein, Gabriel, Lorenzi, Philip L., Børresen-Dale, Anne-Lise, Chin, Koei, Gray, Joe, Dusetti, Nelson J., McGuire, Sean E., Flores, Elsa R., Sood, Anil K., Mills, Gordon B.

“…Small noncoding miRNAs represent underexplored targets of genomic aberrations and emerging therapeutic targets. The 3q26.2 amplicon is among the most frequent…”
Get full text

Tumor Protein 53-induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function by CANO, Carla E, GOMMEAUX, Julien, DUSETTI, Nelson J, IOVANNA, Juan L, CARRIER, Alice, PIETRI, Sylvia, CULCASI, Marcel, GARCIA, Stéphane, SEUX, Mylène, BARELIER, Sarah, VASSEUR, Sophie, SPOTO, Rose P, PEBUSQUE, Marie-Josèphe

“…p53 exerts its tumor suppressor function mainly through transcriptional induction of target genes involved in several processes, including cell cycle…”
Get full text

CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response by Marazita, Mariela C, Ogara, M Florencia, Sonzogni, Silvina V, Martí, Marcelo, Dusetti, Nelson J, Pignataro, Omar P, Cánepa, Eduardo T

“…DNA damage triggers a phosphorylation-based signaling cascade known as the DNA damage response. p19INK4d, a member of the INK4 family of CDK4/6 inhibitors, has…”
Get full text

Absence of tumor suppressor tumor protein 53-induced nuclear protein 1 (TP53INP1) sensitizes mouse thymocytes and embryonic fibroblasts to redox-driven apoptosis by N'guessan, Prudence, Pouyet, Laurent, Gosset, Gaëlle, Hamlaoui, Sonia, Seillier, Marion, Cano, Carla E, Seux, Mylène, Stocker, Pierre, Culcasi, Marcel, Iovanna, Juan L, Dusetti, Nelson J, Pietri, Sylvia, Carrier, Alice

“…The p53-transcriptional target TP53INP1 is a potent stress-response protein promoting p53 activity. We previously showed that ectopic overexpression of…”
Get more information

TP53INP1s and Homeodomain-interacting Protein Kinase-2 (HIPK2) Are Partners in Regulating p53 Activity by Tomasini, Richard, Samir, Amina Azizi, Carrier, Alice, Isnardon, Daniel, Cecchinelli, Barbara, Soddu, Silvia, Malissen, Bernard, Dagorn, Jean-Charles, Iovanna, Juan L., Dusetti, Nelson J.

“…The TP53INP1 gene encodes two protein isoforms, TP53INP1α and TP53INP1β, located into the nucleus. Their synthesis is increased during cellular stress by…”
Get full text

A Transcriptomic-Based Tool to Predict Gemcitabine Sensitivity in Advanced Pancreatic Adenocarcinoma by Fraunhoffer, Nicolas, Chanez, Brice, Teyssedou, Carlos, Bigonnet, Martin, Bongrain, Claire, Lermite, Emilie, Pessaux, Patrick, Giannone, Fabio, Chenard, Marie-Pierre, Michalak, Sophie, Nicolle, Rémy, Rubis, Marion, Poizat, Flora, Giovannini, Marc, Caillol, Fabrice, Rochigneux, Philippe, Iovanna, Juan L., Mitry, Emmanuel, Dusetti, Nelson J.

Get full text

The Functional Landscape of Hsp27 Reveals New Cellular Processes such as DNA Repair and Alternative Splicing and Proposes Novel Anticancer Targets by Katsogiannou, Maria, Andrieu, Claudia, Baylot, Virginie, Baudot, Anaïs, Dusetti, Nelson J., Gayet, Odile, Finetti, Pascal, Garrido, Carmen, Birnbaum, Daniel, Bertucci, François, Brun, Christine, Rocchi, Palma

“…Previously, we identified the stress-induced chaperone, Hsp27, as highly overexpressed in castration-resistant prostate cancer and developed an Hsp27 inhibitor…”
Get full text

Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis by McCleary-Wheeler, Angela L, Lomberk, Gwen A, Weiss, Frank U, Schneider, Günter, Fabbri, Muller, Poshusta, Tara L, Dusetti, Nelson J, Baumgart, Sandra, Iovanna, Juan L, Ellenrieder, Volker, Urrutia, Raul, Fernandez-Zapico, Martin E

“…Highlights ► Epigenetics regulates gene expression by a mechanism unrelated to DNA sequence changes. ► Epigenetic events are involved in promotion and…”
Get full text

Pancreatic ductal adenocarcinoma ubiquitination profiling reveals specific prognostic and theranostic markers by El Kaoutari, Abdessamad, Fraunhoffer, Nicolas A., Audebert, Stéphane, Camoin, Luc, Berthois, Yolande, Gayet, Odile, Roques, Julie, Bigonnet, Martin, Bongrain, Claire, Ciccolini, Joseph, Iovanna, Juan L., Dusetti, Nelson J., Soubeyran, Philippe

“…Pancreatic ductal adenocarcinoma (PDAC) has been widely studied at multiomics level. However, little is known about its specific ubiquitination, a major…”
Get full text

Exploring the Complementarity of Pancreatic Ductal Adenocarcinoma Preclinical Models by Hoare, Owen, Fraunhoffer, Nicolas, Elkaoutari, Abdessamad, Gayet, Odile, Bigonnet, Martin, Roques, Julie, Nicolle, Rémy, McGuckin, Colin, Forraz, Nico, Sohier, Emilie, Tonon, Laurie, Wajda, Pauline, Boyault, Sandrine, Attignon, Valéry, Tabone-Eglinger, Séverine, Barbier, Sandrine, Mignard, Caroline, Duchamp, Olivier, Iovanna, Juan, Dusetti, Nelson J.

“…Purpose: Compare pancreatic ductal adenocarcinoma (PDAC), preclinical models, by their transcriptome and drug response landscapes to evaluate their…”
Get full text

Meaning of tumor protein 53-induced nuclear protein 1 in the molecular mechanism of gemcitabine sensitivity by NAKAYA, NAOKI, ISHIGAKI, YASUHITO, NAKAJIMA, HIDEO, MURAKAMI, MANABU, SHIMASAKI, TAKEO, TAKATA, TAKANOBU, OZAKI, MAMORU, DUSETTI, NELSON J, IOVANNA, JUAN L, MOTOO, YOSHIHARU

“…Stress proteins of the pancreas, such as tumor protein 53-induced nuclear protein 1 (TP53INP1), are important factors in the invasion and metastasis of…”
Get full text

Abstract 4842: TP53INP1 negatively regulates ERK1/2 via p73-dependent DUSP10 expression to promote metastasis in hepatocellular carcinoma by Ng, Kai Yu, Chan, Lok Hei, Chai, Stella, Tong, Man, Guan, Xin Yuan, Lee, Nikki P, Yuan, Yun Fei, Xie, Dan, Lee, Terence K, Carrier, Alice, Dusetti, Nelson J, Ma, Stephanie

“…Abstract The recurrence and metastasis of hepatocellular carcinoma (HCC) portends a poor prognosis and represents important clinical challenges. There is a…”
Get full text

TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity by TOMASINI, Richard, SEUX, Mylène, NOWAK, Jonathan, BONTEMPS, Caroline, CARRIER, Alice, DAGORN, Jean-Charles, PEBUSQUE, Marie-Josèphe, IOVANNA, Juan L, DUSETTI, Nelson J

“…TP53INP1 is an alternatively spliced gene encoding two nuclear protein isoforms (TP53INP1alpha and TP53INP1beta), whose transcription is activated by p53. When…”
Get full text

Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: A yeast two-hybrid approach by Thalappilly, Subhash, Suliman, Muhtadi, Gayet, Odile, Soubeyran, Philippe, Hermant, Aurélie, Lecine, Patrick, Iovanna, Juan L, Dusetti, Nelson J

“…Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease that shows minimal response to chemotherapy. Genetic changes involved in the progression of PDAC…”
Get full text

MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells by Arnaud, Camille, Sebbagh, Michaël, Nola, Sébastien, Audebert, Stéphane, Bidaut, Ghislain, Hermant, Aurélie, Gayet, Odile, Dusetti, Nelson J., Ollendorff, Vincent, Santoni, Marie-Josée, Borg, Jean-Paul, Lécine, Patrick

“…To further characterize the molecular events supporting the tumor suppressor activity of Scrib in mammals, we aim to identify new binding partners. We isolated…”
Get full text

Corrigendum to “Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis” [Cancer Lett. 328 (2) (2012) 212–221] by McCleary-Wheeler, Angela L, Lomberk, Gwen A, Weiss, Frank U, Schneider, Günter, Fabbri, Muller, Poshusta, Tara L, Dusetti, Nelson J, Baumgart, Sandra, Iovanna, Juan L, Ellenrieder, Volker, Urrutia, Raul, Fernandez-Zapico, Martin E

Get full text

Redox-sensitive TP53INP1 SUMOylation as an oxidative stress sensor to activate TP53 by Bonacci, Thomas, Peuget, Sylvain, Soubeyran, Philippe, Iovanna, Juan, Dusetti, Nelson J

“…Oxidative stress-induced sumoylation of TP53INP1 (tumor protein p53-induced nuclear protein 1) is essential to enhance the TP53 response. Sumoylation of…”
Get full text

MicroRNAs in Pancreatic Ductal Adenocarcinoma: New Diagnostic and Therapeutic Clues by Seux, Mylene, lovanna, Juan, Dagorn, Jean-Charles, Dusetti, Nelson J

“…Abstract MicroRNAs (miRNAs) are small non-coding RNAs 19–24 nucleotides in length that regulate gene expression of target genes by translational repression…”
Get full text