Search Results - "Nelson, Daniel P"

Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus by ZHIGANG HONG, FANGXIAO HONG, OLSCHEWSKI, Andrea, CABRERA, Jesus A, VARGHESE, Anthony, NELSON, Daniel P, WEIR, E. Kenneth

“…At birth, the increase in oxygen causes contraction of the ductus arteriosus, thus diverting blood flow to the lungs. Although this contraction is modulated by…”
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Subacute Hypoxia Decreases Voltage-Activated Potassium Channel Expression and Function in Pulmonary Artery Myocytes by Hong, Zhigang, Weir, E. Kenneth, Nelson, Daniel P, Olschewski, Andrea

“…Chronic hypoxia results in both structural changes in the pulmonary artery and a sustained increase in pulmonary vascular tone. This study investigated the…”
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Nitric Oxide and cGMP Cause Vasorelaxation by Activation of a Charybdotoxin-Sensitive K Channel by cGMP-Dependent Protein Kinase by Archer, S L, Huang, J M, Hampl, V, Nelson, D P, Shultz, P J, Weir, E K

“…Nitric oxide (NO)-induced relaxation is associated with increased levels of cGMP in vascular smooth muscle cells. However, the mechanism by which cGMP causes…”
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Redox control of oxygen sensing in the rabbit ductus arteriosus by Reeve, Helen L., Tolarova, Simona, Nelson, Daniel P., Archer, Stephen, Weir, E. Kenneth

“…How the ductus arteriosus (DA) closes at birth remains unclear. Inhibition of O 2 -sensitive K + channels may initiate the closure but the sensor mechanism is…”
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Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction by KENNETH WEIR, E, REEVE, H. L, HUANG, J. M. C, MICHELAKIS, E, NELSON, D. P, HAMPL, V, ARCHER, S. L

“…The appetite suppressant aminorex fumarate is thought to have caused an epidemic of pulmonary hypertension in Europe in the 1960s. More recently, pulmonary…”
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Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine by Hong, Zhigang, Olschewski, Andrea, Reeve, Helen L, Nelson, Daniel P, Hong, Fangxiao, Weir, E Kenneth

“…The anorectic agent dexfenfluramine (dex) causes the development of primary pulmonary hypertension in susceptible patients by an unknown mechanism. We compared…”
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A role for potassium channels in smooth muscle cells and platelets in the etiology of primary pulmonary hypertension by Weir, E K, Reeve, H L, Johnson, G, Michelakis, E D, Nelson, D P, Archer, S L

“…Plasma serotonin levels are markedly elevated in patients with primary pulmonary hypertension (PPH) and platelet levels of serotonin are low. Furthermore,…”
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O2 Sensing Is Preserved in Mice Lacking the gp91 Phox Subunit of NADPH Oxidase by Archer, Stephen L., Reeve, Helen L., Michelakis, Evangelos, Puttagunta, Lakshmi, Waite, Ross, Nelson, Daniel P., Dinauer, Mary C., Weir, E. Kenneth

“…The rapid response to hypoxia in the pulmonary artery (PA), carotid body, and ductus arteriosus is partially mediated by O2-responsive K+ channels. K+ channels…”
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Graded response of K+ current, membrane potential, and [Ca2+]i to hypoxia in pulmonary arterial smooth muscle by Olschewski, Andrea, Hong, Zhigang, Nelson, Daniel P, Weir, E Kenneth

“…Many studies indicate that hypoxic inhibition of some K+ channels in the membrane of the pulmonary arterial smooth muscle cells (PASMCs) plays a part in…”
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Pergolide is an inhibitor of voltage-gated potassium channels, including Kv1.5, and causes pulmonary vasoconstriction by ZHIGANG HONG, SMITH, Andrew J, ARCHER, Stephen L, WU, Xi-Chen, NELSON, Daniel P, PETERSON, Douglas, JOHNSON, Gerhard, WEIR, E. Kenneth

“…Pergolide produces clinical benefit in Parkinson disease by stimulating dopamine D1 and D2 receptors. An increased incidence of carcinoid-like heart valve…”
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Opposite effects of redox status on membrane potential, cytosolic calcium, and tone in pulmonary arteries and ductus arteriosus by Olschewski, Andrea, Hong, Zhigang, Peterson, Douglas A, Nelson, Daniel P, Porter, Valerie A, Weir, E Kenneth

“…At birth, associated with the rise in oxygen tension, the pulmonary arteries (PA) dilate and the ductus arteriosus (DA) constricts. Both PA and DA constrict…”
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Increased release of serotonin from rat ileum due to dexfenfluramine by Rezaie-Majd, Shahrzad, Murar, Jozef, Nelson, Daniel P, Kelly, Rosemary F, Hong, Zhigang, Lang, Irene M, Varghese, Anthony, Weir, E Kenneth

“…Plasma levels of serotonin are elevated in primary pulmonary hypertension even after bilateral lung transplantation, suggesting a possible etiologic role…”
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Effects of fluoxetine, phentermine, and venlafaxine on pulmonary arterial pressure and electrophysiology by Reeve, H L, Nelson, D P, Archer, S L, Weir, E K

“…The anorexic agents dexfenfluramine and fenfluramine plus phentermine have been associated with outbreaks of pulmonary hypertension. The fenfluramines release…”
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Dexfenfluramine elevates systemic blood pressure by inhibiting potassium currents in vascular smooth muscle cells by Michelakis, E D, Weir, E K, Nelson, D P, Reeve, H L, Tolarova, S, Archer, S L

“…Appetite suppressants, such as dexfenfluramine (dex), are associated with primary pulmonary hypertension, valvular heart disease, and systemic vascular…”
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Dithionite Increases Radical Formation and Decreases Vasoconstriction in the Lung: Evidence That Dithionite Does Not Mimic Alveolar Hypoxia by Archer, Stephen L, Hampl, Vaclav, Nelson, Daniel P, Sidney, Erika, Peterson, Douglas A, Weir, E. Kenneth

“…Dithionite is a powerful reducing agent used to deoxygenate hemoglobin and create anaerobic conditions in vitro.Recently, dithionite has been used as a…”
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Low potassium dextran lung preservation solution reduces reactive oxygen species production by Kelly, Rosemary F, Murar, Jozef, Hong, Zhigang, Nelson, Daniel P, Hong, Fangxiao, Varghese, Anthony, Weir, E.Kenneth

“…Low potassium dextran lung preservation solution has reduced primary graft failure in animal and human studies. Though the mechanism of reducing primary graft…”
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O 2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase by Archer, Stephen L., Reeve, Helen L., Michelakis, Evangelos, Puttagunta, Lakshmi, Waite, Ross, Nelson, Daniel P., Dinauer, Mary C., Weir, E. Kenneth

“…The rapid response to hypoxia in the pulmonary artery (PA), carotid body, and ductus arteriosus is partially mediated by O 2 -responsive K + channels. K +…”
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Utility of a nitric oxide electrode for monitoring the administration of nitric oxide in biologic systems by Tristani-Firouzi, Martin, Demaster, Eugene G., Quast, Barry J., Nelson, Daniel P., Archer, Stephen L.

“…Amperometric techniques for the detection of nitric oxide (NO) are commercially available, but their sensitivity and specificity are not well described. We…”
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Oxygen and redox sensitivity of K+ channels in the ductus arteriosus by Weir, E.Kenneth, Tolarova, Simona, Nelson, Daniel P., Archer, Stephen L., Reeve, Helen L.

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Potassium channel diversity in vascular smooth muscle cells by Michelakis, E D, Reeve, H L, Huang, J M, Tolarova, S, Nelson, D P, Weir, E K, Archer, S L

“…Several recent observations suggest that the vascular medium is a mosaic of functionally and morphologically unique cell types. This diversity includes…”
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