Search Results - "Nelson, Cassandra"
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Teaching Coinciding Remote and In Person Systems Physiology Courses: Lessons Learned
Published in The FASEB journal (01-05-2022)“…In the fall 2021 semester, my university offered students the option of taking our 3‐credit Systems Physiology course, designed for juniors and seniors,…”
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Effects of low cell pH and elevated inorganic phosphate on the pCa-force relationship in single muscle fibers at near-physiological temperatures
Published in American Journal of Physiology: Cell Physiology (01-04-2014)“…Intense muscle contraction induces high rates of ATP hydrolysis with resulting increases in Pi, H(+), and ADP, factors thought to induce fatigue by interfering…”
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The human innate immune protein calprotectin induces iron starvation responses in Pseudomonas aeruginosa
Published in The Journal of biological chemistry (08-03-2019)“…Most microbial pathogens have a metabolic iron requirement, necessitating the acquisition of this nutrient in the host. In response to pathogen invasion, the…”
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Proteomic Analysis of the Pseudomonas aeruginosa Iron Starvation Response Reveals PrrF Small Regulatory RNA-Dependent Iron Regulation of Twitching Motility, Amino Acid Metabolism, and Zinc Homeostasis Proteins
Published in Journal of bacteriology (15-06-2019)“…Iron is a critical nutrient for most microbial pathogens, and the immune system exploits this requirement by sequestering iron. The opportunistic pathogen…”
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Structural and Functional Analysis of a Lytic Polysaccharide Monooxygenase Important for Efficient Utilization of Chitin in Cellvibrio japonicus
Published in The Journal of biological chemistry (01-04-2016)“…Cellvibrio japonicus is a Gram-negative soil bacterium that is primarily known for its ability to degrade plant cell wall polysaccharides through utilization…”
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In-Frame Deletions Allow Functional Characterization of Complex Cellulose Degradation Phenotypes in Cellvibrio japonicus
Published in Applied and environmental microbiology (01-09-2015)“…The depolymerization of the recalcitrant polysaccharides found in lignocellulose has become an area of intense interest due to the role of this process in…”
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Phosphate and acidosis act synergistically to depress peak power in rat muscle fibers
Published in American Journal of Physiology: Cell Physiology (15-11-2014)“…Skeletal muscle fatigue is characterized by the buildup of H(+) and inorganic phosphate (Pi), metabolites that are thought to cause fatigue by inhibiting…”
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Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2
Published in The Journal of immunology (1950) (15-04-2016)“…Tumor-induced myeloid-derived suppressor cells (MDSC) contribute to immune suppression in tumor-bearing individuals and are a major obstacle to effective…”
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Heme protects Pseudomonas aeruginosa and Staphylococcus aureus from calprotectin-induced iron starvation
Published in The Journal of biological chemistry (01-01-2021)“…Pseudomonas aeruginosa and Staphylococcus aureus are opportunistic bacterial pathogens that cause severe infections in immunocompromised individuals and…”
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Comprehensive functional characterization of the glycoside hydrolase family 3 enzymes from Cellvibrio japonicus reveals unique metabolic roles in biomass saccharification
Published in Environmental microbiology (01-12-2017)“…Summary Lignocellulose degradation is central to the carbon cycle and renewable biotechnologies. The xyloglucan (XyG), β(1→3)/β(1→4) mixed‐linkage glucan (MLG)…”
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Systems analysis in Cellvibrio japonicus resolves predicted redundancy of β‐glucosidases and determines essential physiological functions
Published in Molecular microbiology (01-04-2017)“…Summary Degradation of polysaccharides forms an essential arc in the carbon cycle, provides a percentage of our daily caloric intake, and is a major driver in…”
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Custom fabrication of biomass containment devices using 3-D printing enables bacterial growth analyses with complex insoluble substrates
Published in Journal of microbiological methods (01-11-2016)“…Physiological studies of recalcitrant polysaccharide degradation are challenging for several reasons, one of which is the difficulty in obtaining a…”
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The Human Innate Immune Protein Calprotectin Elicits a Multimetal Starvation Response in Pseudomonas aeruginosa
Published in Microbiology spectrum (31-10-2021)“…To combat infections, the mammalian host limits availability of essential transition metals such as iron (Fe), zinc (Zn), and manganese (Mn) in a strategy…”
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ExpR coordinates the expression of symbiotically important, bundle-forming Flp pili with quorum sensing in Sinorhizobium meliloti
Published in Applied and Environmental Microbiology (01-04-2014)“…Type IVb pili in enteropathogenic bacteria function as a host colonization factor by mediating tight adherence to host cells, but their role in bacterium-plant…”
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Quality improvement initiative to improve communication domains of patient satisfaction in a regional community hospital with Six Sigma methodology
Published in BMJ open quality (30-12-2023)“…BackgroundCommunication gaps, whether incomplete or fragmented communication, have been the cause of many disasters in human civilisation. Coordination of…”
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Report of the 2018-2019 Research and Graduate Affairs Committee
Published in American journal of pharmaceutical education (01-12-2019)“…The 2018-2019 Research and Graduate Affairs Committee (RGAC) was charged with critically evaluating the leadership development support necessary for pharmacy…”
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Teaching Physiology in a Large Lecture During Covid: The Power of Reflection and Learning Who My Students Are
Published in The FASEB journal (01-05-2021)“…The year 2020 brought challenges to every facet of our daily lives, and higher education was no exception. As a member of the teaching faculty at a large,…”
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Abstract 505: Optimized 7-Plex cell-free DNA assay for clinically relevant KRAS mutations in colorectal cancer
Published in Cancer research (Chicago, Ill.) (15-07-2016)“…Background: KRAS gene mutations are present in approximately 40% of colorectal adenocarcinomas and predict for nonresponse to the anti-epidermal growth factor…”
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Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice
Published in The Journal of nutrition (01-02-2006)“…Genistein, an isoflavone in soybean products, has estrogenic activity and is used as a natural substitute for estrogen replacement therapy in postmenopausal…”
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In vitro and in vivo characterization of three Cellvibrio japonicus glycoside hydrolase family 5 members reveals potent xyloglucan backbone-cleaving functions
Published in Biotechnology for biofuels (17-02-2018)“…Xyloglucan (XyG) is a ubiquitous and fundamental polysaccharide of plant cell walls. Due to its structural complexity, XyG requires a combination of…”
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