Search Results - "Nelson, Annabel"
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Impaired phonemic discrimination in logopenic variant primary progressive aphasia
Published in Annals of clinical and translational neurology (01-07-2020)“…Logopenic variant primary progressive aphasia (lvPPA) is the least well defined of the major primary progressive aphasia (PPA) syndromes. We assessed phoneme…”
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2
The CBI‐R detects early behavioural impairment in genetic frontotemporal dementia
Published in Annals of clinical and translational neurology (01-05-2022)“…Introduction Behavioural dysfunction is a key feature of genetic frontotemporal dementia (FTD) but validated clinical scales measuring behaviour are lacking at…”
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The Cambridge Behavioural Inventory (revised) detects early behavioural and functional impairment in genetic frontotemporal dementia within the GENFI cohort
Published in Alzheimer's & dementia (01-12-2021)“…Background Behavioural dysfunction is a key feature of genetic frontotemporal dementia (FTD) but validated clinical scales measuring behaviour are lacking at…”
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4
121 The Queen Square tests of auditory cognition: defining hearing deficits and dis- ability in dementia
Published in Journal of neurology, neurosurgery and psychiatry (01-06-2022)“…BackgroundHearing impairment has emerged as a potent association of cognitive decline in dementia and a promising treatment target. To realise this promise, we…”
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Processing of acoustically degraded emotional prosody in Alzheimer’s disease and primary progressive aphasia
Published in Alzheimer's & dementia (01-12-2023)“…Background Accurately interpreting a speaker’s nonverbal emotional vocal signals (their prosody) is often essential for successful communication. In the noisy…”
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Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia
Published in Brain (London, England : 1878) (01-01-2023)“…Connections among brain regions allow pathological perturbations to spread from a single source region to multiple regions. Patterns of neurodegeneration in…”
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Parallel Session 2: Neurodegeneration| Wed 18 May, 1115 – 1230|2 Degraded speech comprehension is a ‘real-world audiogram’ for dementia
Published in Journal of neurology, neurosurgery and psychiatry (01-09-2022)“…UCLThe recently recognised association between hearing impairment and dementia has important clinical and public health implications but remains poorly…”
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Comprehension of acoustically degraded speech in Alzheimer’s disease and primary progressive aphasia
Published in Brain (London, England : 1878) (03-10-2023)“…Abstract Successful communication in daily life depends on accurate decoding of speech signals that are acoustically degraded by challenging listening…”
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Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
Published in Journal of neurology, neurosurgery and psychiatry (01-07-2022)“…ObjectiveA GGGGCC repeat expansion in the C9orf72 gene is the most common cause of genetic frontotemporal dementia (FTD) and amyotrophic lateral sclerosis…”
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Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia
Published in Alzheimer's & dementia (01-07-2022)“…The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and…”
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Neuropsychiatric symptoms in genetic frontotemporal dementia: developing a new module for Clinical Rating Scales
Published in Journal of neurology, neurosurgery and psychiatry (01-05-2023)“…BackgroundCurrent clinical rating scales in frontotemporal dementia (FTD) often do not incorporate neuropsychiatric features and may therefore inadequately…”
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Longitudinal Cognitive Changes in Genetic Frontotemporal Dementia Within the GENFI Cohort
Published in Neurology (19-07-2022)“…Disease-modifying therapeutic trials for genetic frontotemporal dementia (FTD) are underway, but sensitive cognitive outcome measures are lacking. The aim of…”
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NfL reliability across laboratories, stage-dependent diagnostic performance and matrix comparability in genetic FTD: a large GENFI study
Published in Journal of neurology, neurosurgery and psychiatry (2024)“…BackgroundBlood neurofilament light chain (NfL) is increasingly considered as a key trial biomarker in genetic frontotemporal dementia (gFTD). We aimed to…”
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Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia
Published in Human brain mapping (01-05-2023)“…© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons…”
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Comparison of clinical rating scales in genetic frontotemporal dementia within the GENFI cohort
Published in Journal of neurology, neurosurgery and psychiatry (01-02-2022)“…BackgroundTherapeutic trials are now underway in genetic forms of frontotemporal dementia (FTD) but clinical outcome measures are limited. The two most…”
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Language impairment in the genetic forms of behavioural variant frontotemporal dementia
Published in Journal of neurology (01-04-2023)“…© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,…”
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Motor symptoms in genetic frontotemporal dementia: developing a new module for clinical rating scales
Published in Journal of neurology (01-03-2023)“…Objective To investigate the optimal method of adding motor features to a clinical rating scale for frontotemporal dementia (FTD). Methods Eight hundred and…”
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Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia: GENFI results
Published in Alzheimer's & dementia (01-05-2024)“…INTRODUCTION Effective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal…”
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Prodromal language impairment in genetic frontotemporal dementia within the GENFI cohort
Published in Journal of the neurological sciences (15-08-2023)“…To identify whether language impairment exists presymptomatically in genetic frontotemporal dementia (FTD), and if so, the key differences between the main…”
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The Benson Complex Figure Test detects deficits in visuoconstruction and visual memory in symptomatic familial frontotemporal dementia: A GENFI study
Published in Journal of the neurological sciences (15-03-2023)“…Sensitive cognitive markers are still needed for frontotemporal dementia (FTD). The Benson Complex Figure Test (BCFT) is an interesting candidate test, as it…”
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