Search Results - "Nelson, Andrew C"

Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy by Nelson, Andrew C., Mould, Arne W., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…Growth and survival of the mammalian embryo within the uterine environment depends on the placenta, a highly complex vascularized organ comprised of both…”
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RHAMM Is a Multifunctional Protein That Regulates Cancer Progression by Messam, Britney J., Tolg, Cornelia, McCarthy, James B., Nelson, Andrew C., Turley, Eva A.

“…The functional complexity of higher organisms is not easily accounted for by the size of their genomes. Rather, complexity appears to be generated by…”
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Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice by Wang, Ying, Chaffee, Thomas S, LaRue, Rebecca S, Huggins, Danielle N, Witschen, Patrice M, Ibrahim, Ayman M, Nelson, Andrew C, Machado, Heather L, Schwertfeger, Kathryn L

“…Tissue-resident macrophages in the mammary gland are found in close association with epithelial structures and within the adipose stroma, and are important for…”
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Conserved non-coding elements and cis regulation: actions speak louder than words by Nelson, Andrew C, Wardle, Fiona C

“…It is a truth (almost) universally acknowledged that conserved non-coding genomic sequences function in the cis regulation of neighbouring genes. But is this a…”
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RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling by Tolg, Cornelia, Milojevic, Maja, Qi, Freda W, Pavanel, Hailie A, Locke, M Elizabeth O, Ma, Jenny, Price, Mathew, Nelson, Andrew C, McCarthy, James B, Hill, Kathleen A, Turley, Eva A

“…RHAMM is a multifunctional protein that is upregulated in breast tumors, and the presence of strongly RHAMM cancer cell subsets associates with elevated risk…”
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Genome-wide analysis of alternative splicing in Caenorhabditis elegans by Ramani, Arun K, Calarco, John A, Pan, Qun, Mavandadi, Sepand, Wang, Ying, Nelson, Andrew C, Lee, Leo J, Morris, Quaid, Blencowe, Benjamin J, Zhen, Mei, Fraser, Andrew G

“…Alternative splicing (AS) plays a crucial role in the diversification of gene function and regulation. Consequently, the systematic identification and…”
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Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation by Mould, Arne W, Morgan, Marc A J, Nelson, Andrew C, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…The neonatal intestine is a very complex and dynamic organ that must rapidly adapt and remodel in response to a barrage of environmental stimuli during the…”
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An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma by Nelson, Andrew C, Pillay, Nischalan, Henderson, Stephen, Presneau, Nadège, Tirabosco, Roberto, Halai, Dina, Berisha, Fitim, Flicek, Paul, Stemple, Derek L, Stern, Claudio D, Wardle, Fiona C, Flanagan, Adrienne M

“…Chordoma is a rare malignant tumour of bone, the molecular marker of which is the expression of the transcription factor, brachyury. Having recently…”
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Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish by Windner, Stefanie E, Doris, Rosemarie A, Ferguson, Chantal M, Nelson, Andrew C, Valentin, Guillaume, Tan, Haihan, Oates, Andrew C, Wardle, Fiona C, Devoto, Stephen H

“…During embryonic development, the paraxial mesoderm becomes segmented into somites, within which proliferative muscle progenitors and muscle fibers establish…”
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Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation by Nelson, Andrew C., Mould, Arne W., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…Trophoblast stem cells (TSCs) give rise to specialized cell types within the placenta. However, the regulatory mechanisms that guide trophoblast cell fate…”
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A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19 by Puskarich, Michael A., Cummins, Nathan W., Ingraham, Nicholas E., Wacker, David A., Reilkoff, Ronald A., Driver, Brian E, Biros, Michelle H., Bellolio, Fernanda, Chipman, Jeffrey G., Nelson, Andrew C., Beckman, Kenneth, Langlois, Ryan, Bold, Tyler, Aliota, Matthew T., Schacker, Timothy W., Voelker, Helen T., Murray, Thomas A, Koopmeiners, Joseph S., Tignanelli, Christopher J.

“…The SARS-CoV-2 virus enters cells via Angiotensin-converting enzyme 2 (ACE2), disrupting the renin-angiotensin-aldosterone axis, potentially contributing to…”
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Optimal detection of clinically relevant mutations in colorectal carcinoma: sample pooling overcomes intra-tumoral heterogeneity by Nelson, Andrew C, Boone, Jamie, Cartwright, David, Thyagarajan, Bharat, Kincaid, Robyn, Lambert, Aaron P, Karnuth, Kylene, Henzler, Christine, Yohe, Sophia

“…Intra-tumoral genomic heterogeneity is a well-established biologic property of human malignancies with emerging roles in cancer progression and therapy…”
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Chondroitin sulfate proteoglycan 4, a targetable oncoantigen that promotes ovarian cancer growth, invasion, cisplatin resistance and spheroid formation by Yang, Jianbo, Liao, Qianjin, Price, Matthew, Moriarity, Branden, Wolf, Natalie, Felices, Martin, Miller, Jeffrey S., Geller, Melissa A., Bendzick, Laura, Hopps, Rachel, Starr, Timothy K., O'Connor, Christine H., Tarullo, Sarah, Nelson, Andrew C., Turley, Eva, Wang, Jing, McCarthy, James B.

“…•Clinical –The studies are the first to identify CSPG4 as an oncoantigen which is associated with poor outcome in patients with ovarian cancer.•CSPG4…”
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In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors by Nelson, Andrew C., Cutty, Stephen J., Gasiunas, Saule N., Deplae, Isabella, Stemple, Derek L., Wardle, Fiona C.

“…T-box transcription factors T/Brachyury homolog A (Ta) and Tbx16 are essential for correct mesoderm development in zebrafish. The downstream transcriptional…”
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High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegans by Ramani, Arun K, Nelson, Andrew C, Kapranov, Philipp, Bell, Ian, Gingeras, Thomas R, Fraser, Andrew G

“…While many genome sequences are complete, transcriptomes are less well characterized. We used both genome-scale tiling arrays and massively parallel sequencing…”
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Saliva Testing Is Accurate for Early-Stage and Presymptomatic COVID-19 by Johnson, Abigail J, Zhou, Shannon, Hoops, Susan L, Hillmann, Benjamin, Schomaker, Matthew, Kincaid, Robyn, Daniel, Jerry, Beckman, Kenneth, Gohl, Daryl M, Yohe, Sophia, Knights, Dan, Nelson, Andrew C

“…Although nasopharyngeal samples have been considered the gold standard for COVID-19 testing, variability in viral load across different anatomical sites could…”
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A cis-regulatory module upstream of deltaC regulated by Ntla and Tbx16 drives expression in the tailbud, presomitic mesoderm and somites by Jahangiri, Leila, Nelson, Andrew C., Wardle, Fiona C.

“…Somites form by an iterative process from unsegmented, presomitic mesoderm (PSM). Notch pathway components, such as deltaC (dlc) have been shown to play a role…”
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The PR/SET Domain Zinc Finger Protein Prdm4 Regulates Gene Expression in Embryonic Stem Cells but Plays a Nonessential Role in the Developing Mouse Embryo by Bogani, Debora, Morgan, Marc A. J., Nelson, Andrew C., Costello, Ita, McGouran, Joanna F., Kessler, Benedikt M., Robertson, Elizabeth J., Bikoff, Elizabeth K.

“…OA  Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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Keratinizing odontogenic cyst with verrucous pattern featuring negative human papillomavirus status by polymerase chain reaction by Argyris, Prokopios P., DDS, MS, Nelson, Andrew C., MD, PhD, Koutlas, Ioannis G., DDS, MS

“…Verrucous odontogenic cysts (OCs) are extremely rare. Here, we report the clinicopathologic features of this unusual entity and investigate the role of human…”
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Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops by Talbot, Conor D, Walsh, Mark D, Cutty, Stephen J, Elsayed, Randa, Vlachaki, Eirini, Bruce, Ashley E E, Wardle, Fiona C, Nelson, Andrew C

“…The T-box family transcription factor Eomesodermin (Eomes) is present in all vertebrates, with many key roles in the developing mammalian embryo and immune…”
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