Search Results - "Nelkin, B."

Overall survival analysis of EXAM, a phase III trial of cabozantinib in patients with radiographically progressive medullary thyroid carcinoma by Schlumberger, M., Elisei, R., Müller, S., Schöffski, P., Brose, M., Shah, M., Licitra, L., Krajewska, J., Kreissl, M.C., Niederle, B., Cohen, E.E.W., Wirth, L., Ali, H., Clary, D.O., Yaron, Y., Mangeshkar, M., Ball, D., Nelkin, B., Sherman, S.

“…Primary analysis of the double-blind, phase III Efficacy of XL184 (Cabozantinib) in Advanced Medullary Thyroid Cancer (EXAM) trial demonstrated significant…”
Get full text

A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours by Wilky, B A, Rudek, M A, Ahmed, S, Laheru, D A, Cosgrove, D, Donehower, R C, Nelkin, B, Ball, D, Doyle, L A, Chen, H, Ye, X, Bigley, G, Womack, C, Azad, N S

“…Background: We completed a phase I clinical trial to test the safety and toxicity of combined treatment with cixutumumab (anti-IGF-1R antibody) and selumetinib…”
Get full text

Methylation-Specific PCR: A Novel PCR Assay for Methylation Status of CpG Islands by Herman, James G., Graff, Jeremy R., Myöhänen, Sanna, Nelkin, Barry D., Baylin, Stephen B.

“…Precise mapping of DNA methylation patterns in CpG islands has become essential for understanding diverse biological processes such as the regulation of…”
Get full text

STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells by Arany, I., Megyesi, J.K., Nelkin, B.D., Safirstein, R.L.

“…We have shown that renal epithelial cell survival depends on the sustained activation of the extracellular signal-regulated protein kinase (ERK) and lack of…”
Get full text

Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice by LINNOILA, R. I, BIHONG ZHAO, DEMAYO, J. L, NELKIN, B. D, BAYLIN, S. B, DEMAYO, F. J, BALL, D. W

“…The transcription factor achaete-scute homologue-1 (ASH1) is essential for neural differentiation during fetal development and is a cardinal feature of…”
Get full text

Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system by SRIURANPONG, Virote, JONG IN PARK, AMORNPHIMOLTHAM, Panomwat, PATEL, Vyomesh, NELKIN, Barry D, GUTKIND, J. Silvio

“…The aberrant growth of head and neck squamous cell carcinoma (HNSCC) is often associated with the constitutive activation of…”
Get full text

p53 activates expression of HIC-1 , a new candidate tumour suppressor gene on 17p13.3 by Wales, Michele Makos, Biel, Margaret A, Deiry, Wafik El, Nelkin, Barry D, Issa, Jean-Pierre, Cavenee, Webster K, Kuerbitz, Steven J, Baylin, Stephen B

“…For several human tumour types, allelic loss data suggest that one or more tumour suppressor genes reside telomeric to the p53 gene at chromosome 17p13.1. In…”
Get full text

Notch signaling induces cell cycle arrest in small cell lung cancer cells by SRIURANPONG, Virote, BORGES, Michael W, RAVI, Rajani K, ARNOLD, Dagmar R, NELKIN, Barry D, BAYLIN, Stephen B, BALL, Douglas W

“…Among the various forms of human lung cancer, small cell lung cancer (SCLC) exhibits a characteristic neuroendocrine (NE) phenotype. Neural and NE…”
Get full text

Increased cytosine DNA-methyltransferase activity during colon cancer progression by Issa, J P, Vertino, P M, Wu, J, Sazawal, S, Celano, P, Nelkin, B D, Hamilton, S R, Baylin, S B

“…Molecular changes during progressive stages of colon cancer and other human tumors commonly involve altered regulation of DNA methylation. These changes…”
Get more information

Expression of an Exogenous Eukaryotic DNA Methyltransferase Gene Induces Transformation of NIH 3T3 Cells by JIANJUN WU, ISSA, J.-P, HERMAN, J, BASSETT, D. E, NELKIN, B. D, BAYLIN, S. B

“…Abnormal regional increases in DNA methylation, which have potential for causing gene inactivation and chromosomal instability, are consistently found in…”
Get full text

The Ras/Raf/MEK/Extracellular Signal-Regulated Kinase Pathway Induces Autocrine-Paracrine Growth Inhibition via the Leukemia Inhibitory Factor/JAK/STAT Pathway by Park, Jong-In, Strock, Christopher J., Ball, Douglas W., Nelkin, Barry D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

High Expression of the DNA Methyltransferase Gene Characterizes Human Neoplastic Cells and Progression Stages of Colon Cancer by El-Deiry, Wafik S., Nelkin, Barry D., Celano, Paul, Yen, Ray-Whay Chiu, Falco, Joseph P., Hamilton, Stanley R., Baylin, Stephen B.

“…DNA methylation abnormalities occur consistently in human neoplasia including widespread hypomethylation and more recently recognized local increases in DNA…”
Get full text

Notch Signaling Induces Rapid Degradation of Achaete-Scute Homolog 1 by Sriuranpong, Virote, Borges, Michael W., Strock, Christopher L., Nakakura, Eric K., Watkins, D. Neil, Blaumueller, Christine M., Nelkin, Barry D., Ball, Douglas W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Identification of a Human Achaete-Scute Homolog Highly Expressed in Neuroendocrine Tumors by Ball, Douglas W., Azzoli, Christopher G., Baylin, Stephen B., Chi, David, Dou, Shenshen, Donis-Keller, Helen, Cumaraswamy, Arunthathi, Borges, Michael, Nelkin, Barry D.

“…Basic helix-loop-helix transcription factors of the achaete-scute family are instrumental in Drosophila neurosensory development and are candidate regulators…”
Get full text

An achaete-scute homologue essential for neuroendocrine differentiation in the lung by Borges, M, Linnoila, R I, van de Velde, H J, Chen, H, Nelkin, B D, Mabry, M, Baylin, S B, Ball, D W

“…In Drosophila and in vertebrates, the achaete-scute family of basic helix-loop-helix transcription factors plays a critical developmental role in neuronal…”
Get full text

Distinct Hypermethylation Patterns Occur at Altered Chromosome Loci in Human Lung and Colon Cancer by Makos, Michele, Nelkin, Barry D., Lerman, Michael I., Latif, Farida, Zbar, Berton, Baylin, Stephen B.

“…Regional increases in DNA methylation occur in normally unmethylated cytosine-rich areas in neoplastic cells. These changes could potentially alter chromatin…”
Get full text

Reactive Oxygen Species Are Critical for the Growth and Differentiation of Medullary Thyroid Carcinoma Cells by HYO CHOL HA, THIAGALINGAM, Arunthathi, NELKIN, Barry D, CASERO, Robert A

“…Reactive oxygen species have recently been demonstrated to play a role in numerous cellular signal transduction pathways. Here we investigate the involvement…”
Get full text

The Short Arm of Chromosome 11 is a ``Hot Spot'' for Hypermethylation in Human Neoplasia by De Bustros, Andrée, Nelkin, Barry D., Silverman, Ann, Ehrlich, Garth, Poiesz, Bernard, Baylin, Stephen B.

“…Inactivation of normally expressed genes may play a role in the formation and/or progression of human cancers. Methylation of cytosine in DNA could potentially…”
Get full text

Isolation and characterization of the cDNA encoding human DNA methyltransferase by Yen, Ray-Whay Chiu, Vertino, Paula M., Nelkin, Barry D., Yu, Jane J., El-Deiry, Wafik, Cumaraswamy, Arunthathi, Lennon, Gregory G., Trask, Barbara J., Celano, Paul, Baylin, Stephen B.

“…We have cloned a series of overlapping cDNA clones encoding a 5194 bp transcript for human DNA methyltransferase (DNA MTase). This sequence potentially codes…”
Get full text

Conservation of the Drosophila Lateral Inhibition Pathway in Human Lung Cancer: A Hairy-Related Protein (HES-1) Directly Represses Achaete-Scute Homolog-1 Expression by Chen, Herbert, Thiagalingam, Arunthathi, Chopra, Hemi, Borges, Michael W., Feder, John N., Nelkin, Barry D., Baylin, Stephen B., Ball, Douglas W.

“…The achaete-scute genes encode essential transcription factors in normal Drosophila and vertebrate nervous system development. Human achaete-scute homolog-1…”
Get full text