The neuroprotective action of enantiomers and racemate of 2-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0oct-2-yl)-4-methylthiobutanoic acid

Neurotropic, neuroprotective and antioxidant actions of the enantiomers and the racemate of 2-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)-4-methylthiobutanoic acid were investigated. Only (+)-(S)-2-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)-4-methylthiobutanoic acid was found to have...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 38; no. 5; p. 621
Main Authors:	Kravchenko, A N, Baranov, V V, Anikina, L V, Vikharev, Iu B, Bushmarinov, I S, Neliubina, Iu V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-2012
Subjects:	Animals Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Butyrates - chemical synthesis Butyrates - chemistry Butyrates - pharmacology Male Mice Molecular Structure Neuroprotective Agents - chemical synthesis Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology
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Summary:	Neurotropic, neuroprotective and antioxidant actions of the enantiomers and the racemate of 2-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)-4-methylthiobutanoic acid were investigated. Only (+)-(S)-2-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)-4-methylthiobutanoic acid was found to have neuroprotective properties. A distereoselective synthesis of enantiomers and racemate was performed by condensations of (S), (R) and (R,S)-N-carbamoylmethionines with 4,5-dihydroxyimidazolidin-2-one (DHI), respectively. By the X-ray method, the major racemate was proved to crystallize from water as a conglomerate. No antioxidant activity was revealed.
ISSN:	0132-3423