Long-term sequelae of chikungunya virus disease: A systematic review

Long-term sequelae of chikungunya virus disease: A systematic review

Abstract Background The acute phase of chikungunya is well documented; less so are its long-term effects. This systematic literature review provides an overview of the currently available data. Methods We performed an electronic search in PubMed/Medline and checked reference lists. We included studi...

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Bibliographic Details
Published in:Travel medicine and infectious disease Vol. 15; pp. 8 - 22
Main Authors: van Aalst, Mariëlle, Nelen, Charlotte Marieke, Goorhuis, Abraham, Stijnis, Cornelis, Grobusch, Martin Peter
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 2017
Elsevier Limited
Subjects:
Adult
Age
Age Factors
Arthralgia
Arthritis
Arthritis - etiology
Baldness
Chikungunya
Chikungunya Fever - complications
Chikungunya Fever - congenital
Chikungunya Fever - epidemiology
Chikungunya Fever - virology
Chikungunya virus
Comorbidity
Congenital chikungunya
Congenital diseases
Depression
Depression - etiology
Disease Outbreaks
Epidemics
Female
Fever
Humans
Infections
Infectious Disease
Literature reviews
Long-term sequelae
Male
Mental depression
Pain
Prospective Studies
Quality of Life
Questionnaires
Risk Factors
Sex Factors
Studies
Surveys and Questionnaires
Systematic review
Time Factors
Travel medicine
Vector-borne diseases
Chikungunya
Depression
Systematic review
Long-term sequelae
Congenital chikungunya
Arthralgia
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Summary:Abstract Background The acute phase of chikungunya is well documented; less so are its long-term effects. This systematic literature review provides an overview of the currently available data. Methods We performed an electronic search in PubMed/Medline and checked reference lists. We included studies in English on long-term sequelae of chikungunya in adults and on long-term sequelae of congenital infection from 2000 to 2016. Case reports, reviews and studies with a follow-up shorter than 6 weeks were excluded. Results In total, 37 studies were included; with follow-up periods ranging from 1.5 to 72 months. Most studies were questionnaire-based studies only, in which clinical diagnoses such as arthritis, alopecia and depression were mostly recorded without professional verification. Persisting arthralgia/arthritis (arthralgia/joint stiffness plus joint swelling) was the most frequent problem encountered. Further frequently mentioned sequelae were alopecia and depression. Quality of life was reduced in many for months to years after the acute phase of chikungunya. Female gender, older age, some co-morbidities and the severity of the acute phase were associated with persistent arthralgia. Congenital infection was associated with neurocognitive dysfunctioning in early childhood. Conclusion Chikungunya leads to (self-perceived) long-term sequelae in a considerable proportion of patients, impacting significantly on quality of life. Long-term chikungunya sequelae must be taken into account when dealing with this disease because of its important effect on public and individual health. Prospective large-scale, long-term studies with objective assessment of signs and symptoms attributed to the disease are needed to optimally quantify and qualify these problems.
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ISSN:1477-8939
1873-0442
DOI:10.1016/j.tmaid.2017.01.004