Search Results - "Nel, E."

Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes by Mirshafiee, Vahid, Sun, Bingbing, Chang, Chong Hyun, Liao, Yu-Pei, Jiang, Wen, Jiang, Jinhong, Liu, Xiangsheng, Wang, Xiang, Xia, Tian, Nel, André E

“…The liver and the mononuclear phagocyte system are a frequent target for engineered nanomaterials, either as a result of particle uptake and spread from…”
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Use of nano engineered approaches to overcome the stromal barrier in pancreatic cancer by Meng, Huan, Nel, Andre E.

“…While chemotherapy is the only approved non-surgical option for the majority of pancreatic cancer patients, it rarely results in a cure. The failure to respond…”
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Nano-Enabled COVID-19 Vaccines: Meeting the Challenges of Durable Antibody Plus Cellular Immunity and Immune Escape by Nel, André E, Miller, Jeff F

“…At the time of preparing this Perspective, large-scale vaccination for COVID-19 is in progress, aiming to bring the pandemic under control through…”
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Engineering an Effective Immune Adjuvant by Designed Control of Shape and Crystallinity of Aluminum Oxyhydroxide Nanoparticles by Sun, Bingbing, Ji, Zhaoxia, Liao, Yu-Pei, Wang, Meiying, Wang, Xiang, Dong, Juyao, Chang, Chong Hyun, Li, Ruibin, Zhang, Haiyuan, Nel, André E, Xia, Tian

“…Adjuvants based on aluminum salts (Alum) are commonly used in vaccines to boost the immune response against infectious agents. However, the detailed mechanism…”
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Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity by Li, Ruibin, Wang, Xiang, Ji, Zhaoxia, Sun, Bingbing, Zhang, Haiyuan, Chang, Chong Hyun, Lin, Sijie, Meng, Huan, Liao, Yu-Pei, Wang, Meiying, Li, Zongxi, Hwang, Angela A, Song, Tze-Bin, Xu, Run, Yang, Yang, Zink, Jeffrey I, Nel, André E, Xia, Tian

“…Functionalized carbon nanotubes (f-CNTs) are being produced in increased volume because of the ease of dispersion and maintenance of the pristine material…”
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Assessing and Mitigating the Hazard Potential of Two-Dimensional Materials by Guiney, Linda M, Wang, Xiang, Xia, Tian, Nel, André E, Hersam, Mark C

“…The family of two-dimensional (2D) materials is comprised of a continually expanding palette of unique compositions and properties with potential applications…”
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Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping by George, Saji, Pokhrel, Suman, Xia, Tian, Gilbert, Benjamin, Ji, Zhaoxia, Schowalter, Marco, Rosenauer, Andreas, Damoiseaux, Robert, Bradley, Kenneth A, Mädler, Lutz, Nel, André E

“…The establishment of verifiably safe nanotechnology requires the development of assessment tools to identify hazardous nanomaterial properties that could be…”
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Multifunctional Lipid Bilayer Nanocarriers for Cancer Immunotherapy in Heterogeneous Tumor Microenvironments, Combining Immunogenic Cell Death Stimuli with Immune Modulatory Drugs by Nel, André E, Mei, Kuo-Ching, Liao, Yu-Pei, Liu, Xiangsheng

“…In addition to the contribution of cancer cells, the solid tumor microenvironment (TME) has a critical role in determining tumor expansion, antitumor immunity,…”
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Designed Synthesis of CeO2 Nanorods and Nanowires for Studying Toxicological Effects of High Aspect Ratio Nanomaterials by Ji, Zhaoxia, Wang, Xiang, Zhang, Haiyuan, Lin, Sijie, Meng, Huan, Sun, Bingbing, George, Saji, Xia, Tian, Nel, André E, Zink, Jeffrey I

“…While it has been shown that high aspect ratio nanomaterials like carbon nanotubes and TiO2 nanowires can induce toxicity by acting as fiber-like substances…”
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Role of Fe Doping in Tuning the Band Gap of TiO2 for the Photo-Oxidation-Induced Cytotoxicity Paradigm by George, Saji, Pokhrel, Suman, Ji, Zhaoxia, Henderson, Bryana L, Xia, Tian, Li, LinJiang, Zink, Jeffrey I, Nel, André E, Mädler, Lutz

“…UV-light-induced electron–hole (e–/h+) pair generation with free radical production in TiO2-based nanoparticles is a major conceptual paradigm for biological…”
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The Fate of ZnO Nanoparticles Administered to Human Bronchial Epithelial Cells by Gilbert, Benjamin, Fakra, Sirine C, Xia, Tian, Pokhrel, Suman, Mädler, Lutz, Nel, André E

“…A particular challenge for nanotoxicology is the evaluation of the biological fate and toxicity of nanomaterials that dissolve in aqueous fluids. Zinc oxide…”
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Zebrafish: An In Vivo Model for Nano EHS Studies by Lin, Sijie, Zhao, Yan, Nel, André E., Lin, Shuo

“…To assure a responsible and sustainable growth of nanotechnology, the environmental health and safety (EHS) aspect of engineered nanomaterials and nano‐related…”
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The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles by Li, Ning, Xia, Tian, Nel, Andre E.

“…Ambient particulate matter (PM) is an environmental factor that has been associated with increased respiratory morbidity and mortality. The major effect of…”
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Surface Defects on Plate-Shaped Silver Nanoparticles Contribute to Its Hazard Potential in a Fish Gill Cell Line and Zebrafish Embryos by George, Saji, Lin, Sijie, Ji, Zhaoxia, Thomas, Courtney R, Li, LinJiang, Mecklenburg, Mathew, Meng, Huan, Wang, Xiang, Zhang, Haiyuan, Xia, Tian, Hohman, J. Nathan, Lin, Shuo, Zink, Jeffrey I, Weiss, Paul S, Nel, André E

“…We investigated and compared nanosize Ag spheres, plates, and wires in a fish gill epithelial cell line (RT-W1) and in zebrafish embryos to understand the…”
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Reduction of Acute Inflammatory Effects of Fumed Silica Nanoparticles in the Lung by Adjusting Silanol Display through Calcination and Metal Doping by Sun, Bingbing, Pokhrel, Suman, Dunphy, Darren R, Zhang, Haiyuan, Ji, Zhaoxia, Wang, Xiang, Wang, Meiying, Liao, Yu-Pei, Chang, Chong Hyun, Dong, Juyao, Li, Ruibin, Mädler, Lutz, Brinker, C. Jeffrey, Nel, André E, Xia, Tian

“…The production of pyrogenic (fumed) silica is increasing worldwide at a 7% annual growth rate, including expanded use in food, pharmaceuticals, and other…”
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Use of Coated Silver Nanoparticles to Understand the Relationship of Particle Dissolution and Bioavailability to Cell and Lung Toxicological Potential by Wang, Xiang, Ji, Zhaoxia, Chang, Chong Hyun, Zhang, Haiyuan, Wang, Meiying, Liao, Yu-Pei, Lin, Sijie, Meng, Huan, Li, Ruibin, Sun, Bingbing, Winkle, Laura Van, Pinkerton, Kent E., Zink, Jeffrey I., Xia, Tian, Nel, André E.

“…Since more than 30% of consumer products that include engineered nanomaterials contain nano‐Ag, the safety of this material is of considerable public concern…”
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Organ-Specific and Size-Dependent Ag Nanoparticle Toxicity in Gills and Intestines of Adult Zebrafish by Osborne, Olivia J, Lin, Sijie, Chang, Chong Hyun, Ji, Zhaoxia, Yu, Xuechen, Wang, Xiang, Lin, Shuo, Xia, Tian, Nel, André E

“…We studied adult zebrafish to determine whether the size of 20 and 110 nm citrate-coated silver nanoparticles (AgC NPs) differentially impact the gills and…”
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Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression by Lu, Jianqin, Liu, Xiangsheng, Liao, Yu-Pei, Salazar, Felix, Sun, Bingbing, Jiang, Wen, Chang, Chong Hyun, Jiang, Jinhong, Wang, Xiang, Wu, Anna M., Meng, Huan, Nel, Andre E.

“…While chemotherapy delivery by nanocarriers has modestly improved the survival prospects of pancreatic ductal adenocarcinoma (PDAC), additional engagement of…”
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Nano Day: Celebrating the Next Decade of Nanoscience and Nanotechnology by Kagan, Cherie R, Fernandez, Laura E, Gogotsi, Yury, Hammond, Paula T, Hersam, Mark C, Nel, André E, Penner, Reginald M, Willson, C. Grant, Weiss, Paul S

“…Nanoscience and nanotechnology are poised to contribute to a wide range of fields, from health and medicine to electronics, energy, security, and more. These…”
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The Genetic Heterogeneity among Different Mouse Strains Impacts the Lung Injury Potential of Multiwalled Carbon Nanotubes by Wang, Xiang, Liao, Yu‐Pei, Telesca, Donatello, Chang, Chong Hyun, Xia, Tian, Nel, André E.

“…Genetic variation constitutes an important variable impacting the susceptibility to inhalable toxic substances and air pollutants, as reflected by…”
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