Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil

Uncertainty remains about how long the protective immune responses against severe acute respiratory syndrome coronavirus 2 persists, and suspected reinfection in recovered patients has been reported. We describe a case of reinfection from distinct virus lineages in Brazil harboring the E484K mutatio...

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Bibliographic Details
Published in:	Emerging infectious diseases Vol. 27; no. 5; pp. 1522 - 1524
Main Authors:	Nonaka, Carolina K V, Franco, Marília Miranda, Gräf, Tiago, de Lorenzo Barcia, Camila Araújo, de Ávila Mendonça, Renata Naves, de Sousa, Karoline Almeida Felix, Neiva, Leila M C, Fosenca, Vagner, Mendes, Ana V A, de Aguiar, Renato Santana, Giovanetti, Marta, de Freitas Souza, Bruno Solano
Format:	Journal Article
Language:	English
Published:	United States U.S. National Center for Infectious Diseases 01-05-2021 Centers for Disease Control and Prevention
Subjects:	Antibodies Case studies coronavirus disease Coronaviruses COVID-19 Diseases Epidemiology Genomes Hospitals Infections Microbial mutation Mutation Phylogenetics Relapse Research Letter respiratory infections SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Viral infections viruses Brazil South Africa Rio de Janeiro Brazil United Kingdom > UK COVID-19 SARS-CoV-2 reinfection viruses E484K spike mutation severe acute respiratory syndrome coronavirus 2 Brazil zoonoses coronavirus disease respiratory infections genomic surveillance
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Summary:	Uncertainty remains about how long the protective immune responses against severe acute respiratory syndrome coronavirus 2 persists, and suspected reinfection in recovered patients has been reported. We describe a case of reinfection from distinct virus lineages in Brazil harboring the E484K mutation, a variant associated with escape from neutralizing antibodies.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2705.210191