Search Results - "Neira, L."

Targeting intrinsically disordered proteins involved in cancer by Santofimia-Castaño, Patricia, Rizzuti, Bruno, Xia, Yi, Abian, Olga, Peng, Ling, Velázquez-Campoy, Adrián, Neira, José L., Iovanna, Juan

“…Intrinsically disordered proteins (IDPs) do not have a well-defined structure under physiological conditions, but they have key roles in cell signaling and…”
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Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis by Santofimia-Castaño, Patricia, Xia, Yi, Lan, Wenjun, Zhou, Zhengwei, Huang, Can, Peng, Ling, Soubeyran, Philippe, Velázquez-Campoy, Adrián, Abián, Olga, Rizzuti, Bruno, Neira, José L, Iovanna, Juan

“…Intrinsically disordered proteins (IDPs) are emerging as attractive drug targets by virtue of their prevalence in various diseases including cancer. Drug…”
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Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma by Neira, José L., Bintz, Jennifer, Arruebo, María, Rizzuti, Bruno, Bonacci, Thomas, Vega, Sonia, Lanas, Angel, Velázquez-Campoy, Adrián, Iovanna, Juan L., Abián, Olga

“…Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and regulatory functions. Often associated with human diseases, they…”
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Isolated auto-citrullinated regions of PADI4 associate to the intact protein without altering their disordered conformation by Neira, José L., Rizzuti, Bruno, Abian, Olga, Velazquez-Campoy, Adrian

“…PADI4 is one of the human isoforms of a group of enzymes intervening in the conversion of arginine to citrulline. It is involved in the development of several…”
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Folding of the nascent polypeptide chain of a histidine phosphocarrier protein in vitro by Neira, José L., Palomino-Schätzlein, Martina

“…The phosphotransferase system (PTS), a metabolic pathway formed by five proteins, modulates the use of sugars in bacteria. The second protein in the chain is…”
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Conformational Stability of the N-Terminal Region of MDM2 by Rizzuti, Bruno, Abian, Olga, Velazquez-Campoy, Adrián, Neira, José L

“…MDM2 is an E3 ubiquitin ligase which is crucial for the degradation and inhibition of the key tumor-suppressor protein p53. In this work, we explored the…”
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Leukocyte apoptosis and its significance in sepsis and shock by Wesche, Doreen E., Lomas‐Neira, Joanne L., Perl, Mario, Chung, Chun‐Shiang, Ayala, Alfred

“…Sepsis and multiple organ failure continue to be significant problems among trauma, burn, and the critically ill patient population. Thus, a number of…”
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Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B by Santofimia-Castaño, Patricia, Rizzuti, Bruno, Pey, Ángel L., Soubeyran, Philippe, Vidal, Miguel, Urrutia, Raúl, Iovanna, Juan L., Neira, José L.

“…Intrinsically disordered proteins (IDPs) are ubiquitous in eukaryotes, and they are often associated with diseases in humans. The protein NUPR1 is a…”
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Intrinsically disordered proteins in biology: One for all, all for one by Yruela, Inmaculada, Neira, José L.

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Intrinsically Disordered Chromatin Protein NUPR1 Binds to the Enzyme PADI4 by Araujo-Abad, Salomé, Neira, José L., Rizzuti, Bruno, García-Morales, Pilar, de Juan Romero, Camino, Santofimia-Castaño, Patricia, Iovanna, Juan

“…[Display omitted] •The cancer-involved human enzyme PADI4 was bound to the disordered NUPR1.•The dissociation constant was in the low micromolar range…”
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Deciphering the Binding of the Nuclear Localization Sequence of Myc Protein to the Nuclear Carrier Importin α3 by Rizzuti, Bruno, Iovanna, Juan L, Neira, José L

“…The oncoprotein Myc is a transcription factor regulating global gene expression and modulating cell proliferation, apoptosis, and metabolism. Myc has a nuclear…”
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Biochemical and biophysical characterization of PADI4 supports its involvement in cancer by Neira, José L., Araujo-Abad, Salomé, Cámara-Artigas, Ana, Rizzuti, Bruno, Abian, Olga, Giudici, Ana Marcela, Velazquez-Campoy, Adrian, de Juan Romero, Camino

“…PADI4 (protein-arginine deiminase, also known as protein l-arginine iminohydrolase) is one of the human isoforms of a family of Ca2+-dependent proteins…”
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Structure and dynamics of the cyanobacterial regulator SipA by Neira, José L., López-Redondo, María Luisa, Cámara-Artigas, Ana, Marina, Alberto, Contreras, Asunción

“…The small, 78-residue long, regulator SipA interacts with the non-bleaching sensor histidine kinase (NblS). We have solved the solution structure of SipA on…”
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The C-terminal SAM domain of p73 binds to the N terminus of MDM2 by Neira, José L., Díaz-García, Clara, Prieto, Manuel, Coutinho, Ana

“…The p53, p63 and p73 proteins belong to the p53 family of transcription factors, playing key roles in tumour suppression. The α-splice variant of p73 (p73α)…”
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Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants by Neira, Jose L, Naganathan, Athi N, Mesa-Torres, Noel, Salido, Eduardo, Pey, Angel L

“…The mutations G170R and I244T are the most common disease cause in primary hyperoxaluria type I (PH1). These mutations cause the misfolding of the AGT protein…”
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The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4 by Neira, José L., Rizzuti, Bruno, Araujo-Abad, Salome, Abian, Olga, Fárez-Vidal, María Esther, Velazquez-Campoy, Adrian, de Juan Romero, Camino

“…Plakophilin 1 (PKP1), a member of the armadillo repeat family of proteins, is a key structural component of cell-cell adhesion scaffolds, although it can also…”
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Citrullinating enzyme PADI4 and transcriptional repressor RING1B bind in cancer cells by Araujo-Abad, Salome, Rizzuti, Bruno, Soto-Conde, Lourdes, Vidal, Miguel, Abian, Olga, Velazquez-Campoy, Adrian, Neira, José L., de Juan Romero, Camino

“…Polycomb groups (PcGs) are transcriptional repressors, formed by a complex of several proteins, involved in multicellular development and cancer epigenetics…”
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The Monomeric Species of the Regulatory Domain of Tyrosine Hydroxylase Has a Low Conformational Stability by Neira, José L, Hornos, Felipe, Bacarizo, Julio, Cámara-Artigás, Ana, Gómez, Javier

“…Tyrosine hydroxylase (TyrH) catalyzes the hydroxylation of tyrosine to form 3,4-dihydroxyphenylalanine, the first step in the synthesis of catecholamine…”
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The isolated GTPase-activating-protein-related domain of neurofibromin-1 has a low conformational stability in solution by Neira, José L., Vega, Sonia, Martínez-Rodríguez, Sergio, Velázquez-Campoy, Adrián

“…Neurofibromin-1 (NF1) is a large, multidomain tumour suppressor encoded by the NF1 gene. The gene is mutated in neurofibromatosis type I, a disease…”
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Dendrimers as Competitors of Protein–Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1 by Neira, José L, Correa, Juan, Rizzuti, Bruno, Santofimia-Castaño, Patricia, Abian, Olga, Velázquez-Campoy, Adrián, Fernandez-Megia, Eduardo, Iovanna, Juan L

“…NUPR1 is a protumoral multifunctional intrinsically disordered protein, which is activated during the acute phases of pancreatitis, interacting with several…”
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