Search Results - "Neilson, Joel R"

MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells by Sharp, Phillip A, Ebert, Margaret S, Neilson, Joel R

“…MicroRNAs are predicted to regulate thousands of mammalian genes, but relatively few targets have been experimentally validated and few microRNA…”
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mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases by Palmieri, Michela, Pal, Rituraj, Nelvagal, Hemanth R., Lotfi, Parisa, Stinnett, Gary R., Seymour, Michelle L., Chaudhury, Arindam, Bajaj, Lakshya, Bondar, Vitaliy V., Bremner, Laura, Saleem, Usama, Tse, Dennis Y., Sanagasetti, Deepthi, Wu, Samuel M., Neilson, Joel R., Pereira, Fred A., Pautler, Robia G., Rodney, George G., Cooper, Jonathan D., Sardiello, Marco

“…Neurodegenerative diseases characterized by aberrant accumulation of undigested cellular components represent unmet medical conditions for which the…”
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The spliceosome is a therapeutic vulnerability in MYC-driven cancer by Hsu, Tiffany Y.-T., Simon, Lukas M., Neill, Nicholas J., Marcotte, Richard, Sayad, Azin, Bland, Christopher S., Echeverria, Gloria V., Sun, Tingting, Kurley, Sarah J., Tyagi, Siddhartha, Karlin, Kristen L., Dominguez-Vidaña, Rocio, Hartman, Jessica D., Renwick, Alexander, Scorsone, Kathleen, Bernardi, Ronald J., Skinner, Samuel O., Jain, Antrix, Orellana, Mayra, Lagisetti, Chandraiah, Golding, Ido, Jung, Sung Y., Neilson, Joel R., Zhang, Xiang H.-F., Cooper, Thomas A., Webb, Thomas R., Neel, Benjamin G., Shaw, Chad A., Westbrook, Thomas F.

“…Splicing factors such as BUD31 are identified in a synthetic-lethal screen with cells overexpressing the transcription factor MYC; oncogenic MYC leads to an…”
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Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132 by Edbauer, Dieter, Neilson, Joel R., Foster, Kelly A., Wang, Chi-Fong, Seeburg, Daniel P., Batterton, Matthew N., Tada, Tomoko, Dolan, Bridget M., Sharp, Phillip A., Sheng, Morgan

“…MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The miRNA machinery interacts with fragile X mental retardation protein…”
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miRNA profiling of naïve, effector and memory CD8 T cells by Wu, Haoquan, Neilson, Joel R, Kumar, Priti, Manocha, Monika, Shankar, Premlata, Sharp, Phillip A, Manjunath, N

“…microRNAs have recently emerged as master regulators of gene expression during development and cell differentiation. Although profound changes in gene…”
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Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction by Pal, Rituraj, Palmieri, Michela, Chaudhury, Arindam, Klisch, Tiemo Jürgen, di Ronza, Alberto, Neilson, Joel R., Rodney, George G., Sardiello, Marco

“…The mechanistic target of rapamycin complex 1 (mTORC1) regulates cell survival and autophagy, and its activity is regulated by amino acid availability. Rag…”
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Loss of MicroRNA-106b-25 Cluster Promotes Atrial Fibrillation by Enhancing Ryanodine Receptor Type-2 Expression and Calcium Release by Chiang, David Y, Kongchan, Natee, Beavers, David L, Alsina, Katherina M, Voigt, Niels, Neilson, Joel R, Jakob, Heinz, Martin, James F, Dobrev, Dobromir, Wehrens, Xander H.T, Li, Na

“…BACKGROUND—Enhanced sarcoplasmic reticulum Ca-leak via ryanodine receptor type-2 (RyR2) contributes to the pathogenesis of atrial fibrillation (AF). Recent…”
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NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21 by Graef, Isabella A, Crabtree, Gerald R, Arron, Joseph R, Winslow, Monte M, Polleri, Alberto, Chang, Ching-Pin, Wu, Hai, Gao, Xin, Neilson, Joel R, Chen, Lei, Heit, Jeremy J, Kim, Seung K, Yamasaki, Nobuyuki, Miyakawa, Tsuyoshi, Francke, Uta

“…Trisomy 21 results in Down's syndrome, but little is known about how a 1.5-fold increase in gene dosage produces the pleiotropic phenotypes of Down's syndrome…”
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Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy by Chern, Tiffany, Achilleos, Annita, Tong, Xuefei, Hill, Matthew C., Saltzman, Alexander B., Reineke, Lucas C., Chaudhury, Arindam, Dasgupta, Swapan K., Redhead, Yushi, Watkins, David, Neilson, Joel R., Thiagarajan, Perumal, Green, Jeremy B. A., Malovannaya, Anna, Martin, James F., Rosenblatt, David S., Poché, Ross A.

“…Combined methylmalonic acidemia and homocystinuria (cblC) is the most common inborn error of intracellular cobalamin metabolism and due to mutations in…”
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CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT by Chaudhury, Arindam, Cheema, Shebna, Fachini, Joseph M., Kongchan, Natee, Lu, Guojun, Simon, Lukas M., Wang, Tao, Mao, Sufeng, Rosen, Daniel G., Ittmann, Michael M., Hilsenbeck, Susan G., Shaw, Chad A., Neilson, Joel R.

“…The importance of translational regulation in tumour biology is increasingly appreciated. Here, we leverage polyribosomal profiling to prospectively define…”
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NUDT21-spanning CNVs lead to neuropsychiatric disease and altered MeCP2 abundance via alternative polyadenylation by Gennarino, Vincenzo A, Alcott, Callison E, Chen, Chun-An, Chaudhury, Arindam, Gillentine, Madelyn A, Rosenfeld, Jill A, Parikh, Sumit, Wheless, James W, Roeder, Elizabeth R, Horovitz, Dafne D G, Roney, Erin K, Smith, Janice L, Cheung, Sau W, Li, Wei, Neilson, Joel R, Schaaf, Christian P, Zoghbi, Huda Y

“…The brain is sensitive to the dose of MeCP2 such that small fluctuations in protein quantity lead to neuropsychiatric disease. Despite the importance of MeCP2…”
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A Field of Myocardial-Endocardial NFAT Signaling Underlies Heart Valve Morphogenesis by Chang, Ching-Pin, Neilson, Joel R., Bayle, J.Henri, Gestwicki, Jason E., Kuo, Ann, Stankunas, Kryn, Graef, Isabella A., Crabtree, Gerald R.

“…The delicate leaflets that make up vertebrate heart valves are essential for our moment-to-moment existence. Abnormalities of valve formation are the most…”
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A powerful statistical approach for large-scale differential transcription analysis by Tan, Yuan-De, Chandler, Anita M, Chaudhury, Arindam, Neilson, Joel R

“…Next generation sequencing (NGS) is increasingly being used for transcriptome-wide analysis of differential gene expression. The NGS data are multidimensional…”
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Differences between acute and chronic stress granules, and how these differences may impact function in human disease by Reineke, Lucas C., Neilson, Joel R.

“…[Display omitted] Stress granules are macromolecular aggregates of mRNA and proteins assembling in response to stresses that promote the repression of protein…”
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Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery by Chang, Ching-Pin, McDill, Bradley W, Neilson, Joel R, Joist, Heidi E, Epstein, Jonathan A, Crabtree, Gerald R, Chen, Feng

“…Congenital obstructive nephropathy is the principal cause of renal failure in infants and children. The underlying molecular and cellular mechanisms of this…”
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The Calcineurin Phosphatase Complex Modulates Immunogenic B Cell Responses by Winslow, Monte M., Gallo, Elena M., Neilson, Joel R., Crabtree, Gerald R.

“…A series of signal-directed transitions regulates the development of distinct populations of self-tolerant B cells and ultimately the production of…”
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Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types by Xia, Zheng, Donehower, Lawrence A., Cooper, Thomas A., Neilson, Joel R., Wheeler, David A., Wagner, Eric J., Li, Wei

“…Alternative polyadenylation (APA) is a pervasive mechanism in the regulation of most human genes, and its implication in diseases including cancer is only…”
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Proliferating Cells Express mRNAs with Shortened 3′ Untranslated Regions and Fewer MicroRNA Target Sites by Sandberg, Rickard, Neilson, Joel R., Sarma, Arup, Sharp, Phillip A., Burge, Christopher B.

“…Messenger RNA (mRNA) stability, localization, and translation are largely determined by sequences in the 3′ untranslated region (3′UTR). We found a conserved…”
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Genetic Loss of Calcineurin Blocks Mechanical Overload-induced Skeletal Muscle Fiber Type Switching but Not Hypertrophy by Parsons, Stephanie A., Millay, Douglas P., Wilkins, Benjamin J., Bueno, Orlando F., Tsika, Gretchen L., Neilson, Joel R., Liberatore, Christine M., Yutzey, Katherine E., Crabtree, Gerald R., Tsika, Richard W., Molkentin, Jeffery D.

“…The serine/threonine phosphatase calcineurin is an important regulator of calcium-activated intracellular responses in eukaryotic cells. In higher eukaryotes,…”
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Calcineurin sets the bandwidth for discrimination of signals during thymocyte development by Radermacher, Amy N, McGinnis, Lisa, Canté-Barrett, Kirsten, Ho, Lena, Winslow, Monte M, Gallo, Elena M, Iritani, Brian, Neilson, Joel R, Crabtree, Gerald R

“…At critical times in development, cells are able to convert graded signals into discrete developmental outcomes; however, the mechanisms involved are poorly…”
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