Search Results - "Neill, Jo C"

A systematic review and meta-analysis of cognitive remediation in early schizophrenia by Revell, Emily R, Neill, Jo C, Harte, Michael, Khan, Zarshed, Drake, Richard J

“…Abstract Neurocognitive impairment predicts disability in schizophrenia, making intervention theoretically attractive as a means to minimise chronic…”
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Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders by McLean, Samantha L., Grayson, Ben, Marsh, Samuel, Zarroug, Samah H.O., Harte, Michael K., Neill, Jo C.

“…•Object recognition memory decays to 0 after a 6h ITI in female hL rats.•Activation of nicotinic α7 and α4b2 receptors restores this memory.•Donepezil restores…”
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Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: Implications for therapy of cognitive dysfunction in schizophrenia by McLean, Samantha L, Grayson, Ben, Idris, Nagi F, Lesage, Anne S, Pemberton, Darrel J, Mackie, Claire, Neill, Jo C

“…Abstract Rationale Nicotinic α7 acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Aim To…”
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Adverse effects of psychedelics: From anecdotes and misinformation to systematic science by Schlag, Anne K, Aday, Jacob, Salam, Iram, Neill, Jo C, Nutt, David J

“…Background: Despite an increasing body of research highlighting their efficacy to treat a broad range of medical conditions, psychedelic drugs remain a…”
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Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats by Damgaard, Trine, Larsen, Dorrit Bjerg, Hansen, Suzanne L., Grayson, Ben, Neill, Jo C., Plath, Niels

“…Cognitive deficits are a major clinical unmet need in schizophrenia. The psychotomimetic drug phencyclidine (PCP) is widely applied in rodents to mimic…”
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Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the rat by McLean, Samantha L., Neill, Jo C., Idris, Nagi F., Marston, Hugh M., Wong, Erik H.F., Shahid, Mohammed

“…Asenapine is a new pharmacological agent for the acute treatment of schizophrenia and bipolar disorder. It has relatively higher affinity for serotonergic and…”
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D1 receptor activation improves vigilance in rats as measured by the 5-choice continuous performance test by Barnes, Samuel A., Young, Jared W., Neill, Jo C.

“…Rationale Impaired attention/vigilance is putatively core to schizophrenia. The dopaminergic D 1 receptor system has been reported as one of the most promising…”
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Effects of cariprazine, a novel antipsychotic, on cognitive deficit and negative symptoms in a rodent model of schizophrenia symptomatology by Neill, Jo C, Grayson, Ben, Kiss, Béla, Gyertyán, István, Ferguson, Paul, Adham, Nika

“…Abstract Negative symptoms and cognitive impairment associated with schizophrenia are strongly associated with poor functional outcome and reduced quality of…”
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Luvadaxistat: A Novel Potent and Selective d-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia by Fradley, Rosa, Goetghebeur, Pascal, Miller, David, Burley, Russell, Almond, Sarah, Gruart i Massó, Agnès, Delgado García, José M., Zhu, Bin, Howley, Eimear, Neill, Jo C., Grayson, Ben, Gaskin, Philip, Carlton, Mark, Gray, Ian, Serrats, Jordi, Davies, Ceri H.

“…N-methyl- d -aspartate (NMDA) receptor hypofunctionality is a well-studied hypothesis for schizophrenia pathophysiology, and daily dosing of the NMDA receptor…”
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Correction to: Luvadaxistat: A Novel Potent and Selective d-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia by Fradley, Rosa, Goetghebeur, Pascal, Miller, David, Burley, Russell, Almond, Sarah, Gruart i Massó, Agnès, Delgado García, José M., Zhu, Bin, Howley, Eimear, Neill, Jo C., Grayson, Ben, Gaskin, Philip, Carlton, Mark, Gray, Ian, Serrats, Jordi, Davies, Ceri H.

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Asenapine improves phencyclidine-induced object recognition deficits in the rat: evidence for engagement of a dopamine D1 receptor mechanism by Snigdha, Shikha, Idris, Nagi, Grayson, Ben, Shahid, Mohammed, Neill, Jo C.

“…Rationale Cognitive deficits are common in schizophrenia. Asenapine is an atypical antipsychotic approved by the US Food and Drug Administration in adults for…”
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Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia by Damgaard, Trine, Plath, Niels, Neill, Jo C., Hansen, Suzanne L.

“…Rationale Schizophrenia is a complex psychiatric disorder comprised of three main classes of symptoms: positive, negative and cognitive symptoms. Currently, no…”
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Nicotinic alpha 7 and alpha 4 beta 2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders by McLean, Samantha L, Grayson, Ben, Marsh, Samuel, Zarroug, Samah HO, Harte, Michael K, Neill, Jo C

“…Cholinergic dysfunction has been shown to be central to the pathophysiology of Alzheimer's disease and has also been postulated to contribute to cognitive…”
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Rats tested after a washout period from sub-chronic PCP administration exhibited impaired performance in the 5-Choice Continuous Performance Test (5C-CPT) when the attentional load was increased by Barnes, Sam A., Young, Jared W., Neill, Jo C.

“…It is well documented that schizophrenia patients exhibit dysfunction in various cognitive domains, including attention/vigilance, as demonstrated by impaired…”
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PNU-120596, a positive allosteric modulator of alpha 7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats by McLean, Samantha L, Idris, Nagi F, Grayson, Ben, Gendle, David F, Mackie, Claire, Lesage, Anne S, Pemberton, Darrel J, Neill, Jo C

“…The alpha 7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister…”
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PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats by McLean, Samantha L, Idris, Nagi F, Grayson, Ben, Gendle, David F, Mackie, Claire, Lesage, Anne S, Pemberton, Darrel J, Neill, Jo C

“…The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats…”
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The preclinical profile of asenapine: clinical relevance for the treatment of schizophrenia and bipolar mania by Tarazi, Frank I, Neill, Jo C

“…Asenapine is a novel antipsychotic drug approved for the treatment of acute schizophrenia, manic, or mixed episodes associated with bipolar I disorder, as a…”
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Activation of alpha 7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: Implications for therapy of cognitive dysfunction in schizophrenia by McLean, Samantha L, Grayson, Ben, Idris, Nagi F, Lesage, Anne S, Pemberton, Darrel J, Mackie, Claire, Neill, Jo C

“…Nicotinic alpha 7 acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Aim: To investigate whether…”
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Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia by Barnes, Samuel A, Sawiak, Stephen J, Caprioli, Daniele, Jupp, Bianca, Buonincontri, Guido, Mar, Adam C, Harte, Michael K, Fletcher, Paul C, Robbins, Trevor W, Neill, Jo C, Dalley, Jeffrey W

“…N-methyl-d-aspartate receptor (NMDAR) dysfunction is thought to contribute to the pathophysiology of schizophrenia. Accordingly, NMDAR antagonists such as…”
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First episode psychosis patients show impaired cognitive function – a study of a South Asian population in the UK by Saleem, Majid M, Harte, Michael K, Marshall, Kay M, Scally, Andy, Brewin, Anita, Neill, Jo C

“…Background: Cognitive deficits are a core symptom of schizophrenia, severely debilitating and untreated by current medication. However, to date there is…”
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