Search Results - "Neil, H. Andrew W"

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study by Talmud, Philippa J, Prof, Shah, Sonia, MSc, Whittall, Ros, MSc, Futema, Marta, BSc, Howard, Philip, BSc, Cooper, Jackie A, MSc, Harrison, Seamus C, MRCS, Li, KaWah, MSc, Drenos, Fotios, PhD, Karpe, Frederik, PhD, Neil, H Andrew W, Prof, Descamps, Olivier S, PhD, Langenberg, Claudia, PhD, Lench, Nicholas, PhD, Kivimaki, Mika, Prof, Whittaker, John, Prof, Hingorani, Aroon D, Prof, Kumari, Meena, PhD, Humphries, Steve E, Prof

“…Summary Background Familial hypercholesterolaemia is a common autosomal-dominant disorder caused by mutations in three known genes. DNA-based cascade testing…”
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10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes by Holman, Rury R, Paul, Sanjoy K, Bethel, M. Angelyn, Matthews, David R, Neil, H. Andrew W

“…This trial was conducted to determine whether the reduction in microvascular risk and improved glycemic control that had been observed with medical therapy, as…”
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Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes by Holman, Rury R, Paul, Sanjoy K, Bethel, M. Angelyn, Neil, H. Andrew W, Matthews, David R

“…A post-trial monitoring study involving follow-up of patients with type 2 diabetes who had been assigned to tight or less-tight blood-pressure control revealed…”
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ACE Inhibitors and Statins in Adolescents with Type 1 Diabetes by Marcovecchio, M. Loredana, Chiesa, Scott T, Bond, Simon, Daneman, Denis, Dawson, Sarah, Donaghue, Kim C, Jones, Timothy W, Mahmud, Farid H, Marshall, Sally M, Neil, H. Andrew W, Dalton, R. Neil, Deanfield, John, Dunger, David B

“…Adolescents with type 1 diabetes received one of four regimens: angiotensin-converting–enzyme (ACE) inhibitor–placebo, statin–placebo, ACE inhibitor–statin, or…”
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Effects of Atorvastatin on Kidney Outcomes and Cardiovascular Disease in Patients With Diabetes: An Analysis From the Collaborative Atorvastatin Diabetes Study (CARDS) by Colhoun, Helen M., MD, Betteridge, D. John, PhD, Durrington, Paul N., MD, Hitman, Graham A., MD, Neil, H. Andrew W., DSc, Livingstone, Shona J., MSc, Charlton-Menys, Valentine, PhD, DeMicco, David A., PharmD, Fuller, John H., FRCP

“…Background We examined whether atorvastatin affects diabetic kidney disease and whether the effect of atorvastatin on cardiovascular disease (CVD) varies by…”
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Use of targeted exome sequencing as a diagnostic tool for Familial Hypercholesterolaemia by Futema, Marta, Plagnol, Vincent, Whittall, Ros A, Neil, H Andrew W, Humphries, Steve Eric

“…Familial Hypercholesterolaemia (FH) is an autosomal dominant disease, caused by mutations in LDLR, APOB or PCSK9, which results in high levels of…”
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LADA and CARDS: A Prospective Study of Clinical Outcome in Established Adult-Onset Autoimmune Diabetes by MOHAMMED IQBAL HAWA, BUCHAN, Ana Paula, COLHOUN, Helen, LESLIE, Richard David, HITMAN, Graham A, OLA, Thomas, CHUAN CHUAN WUN, DEMICCO, David A, WEIHANG BAO, BETTERIDGE, D. John, DURRINGTON, Paul N, FULLER, John H, NEIL, H. Andrew W

“…Diabetes-associated autoantibodies can be detected in adult-onset diabetes, even when initially non-insulin requiring, i.e., with latent autoimmune diabetes…”
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A new strategy for vascular complications in young people with type 1 diabetes mellitus by Marcovecchio, M. Loredana, Dalton, R. Neil, Daneman, Denis, Deanfield, John, Jones, Timothy W., Neil, H. Andrew W., Dunger, David B.

“…Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of…”
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Relationship of Disordered Eating Habits and Attitudes to Clinical Outcomes in Young Adult Females With Type 1 Diabetes by Peveler, Robert C, Bryden, Kathryn S, Neil, H. Andrew W, Fairburn, Christopher G, Mayou, Richard A, Dunger, David B, Turner, Hannah M

“…OBJECTIVE:--To describe the clinical outcomes of adolescent and young adult female subjects with type 1 diabetes in relation to the disturbance of eating…”
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Targets of Statin Therapy: LDL Cholesterol, Non-HDL Cholesterol, and Apolipoprotein B in Type 2 Diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS) by Charlton-Menys, Valentine, Betteridge, D. John, Colhoun, Helen, Fuller, John, France, Michael, Hitman, Graham A, Livingstone, Shona J, Neil, H. Andrew W, Newman, Connie B, Szarek, Michael, DeMicco, David A, Durrington, Paul N

“…LDL can vary considerably in its cholesterol content; thus, lowering LDL cholesterol (LDLC) as a goal of statin treatment implies the existence of considerable…”
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The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men by Scartezini, Marileia, Hubbart, Christina, Whittall, Ros A, Cooper, Jackie A, Neil, Andrew H W, Humphries, Steve E

“…In the present study, we have determined the relative frequency of the R46L, I474V and E670G variants in the PCSK9 (protein convertase subtilisin/kexin type 9)…”
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Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial by Colhoun, Helen M, Betteridge, D John, Durrington, Paul N, Hitman, Graham A, W Neil, H Andrew, Livingstone, Shona J, Thomason, Margaret J, Mackness, Michael I, Charlton-Menys, Valentine, Fuller, John H

“…Type 2 diabetes is associated with a substantially increased risk of cardiovascular disease, but the role of lipid-lowering therapy with statins for the…”
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Analysis of the frequency and spectrum of mutations recognised to cause familial hypercholesterolaemia in routine clinical practice in a UK specialist hospital lipid clinic by Futema, Marta, Whittall, Ros A, Kiley, Amy, Steel, Louisa K, Cooper, Jackie A, Badmus, Ebele, Leigh, Sarah E, Karpe, Fredrik, Neil, H. Andrew W, Humphries, Steve E

“…Abstract Aim To determine the frequency and spectrum of mutations causing Familial Hypercholesterolaemia (FH) in patients attending a single UK specialist…”
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Urinary albumin/creatinine ratio tertiles predict risk of diabetic retinopathy progression: a natural history study from the Adolescent Cardio-Renal Intervention Trial (AdDIT) observational cohort by Benitez-Aguirre, Paul Z., Marcovecchio, M. Loredana, Chiesa, Scott T., Craig, Maria E., Wong, Tien Y., Davis, Elizabeth A., Cotterill, Andrew, Couper, Jenny J., Cameron, Fergus J., Mahmud, Farid H., Neil, H. Andrew W., Jones, Timothy W., Hodgson, Lauren A. B., Dalton, R. Neil, Marshall, Sally M., Deanfield, John, Dunger, David B., Donaghue, Kim C.

“…Aims/hypothesis We hypothesised that adolescents with type 1 diabetes with a urinary albumin/creatinine ratio (ACR) in the upper tertile of the normal range…”
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Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes by Chiesa, Scott T., Marcovecchio, M. Loredana, Benitez-Aguirre, Paul, Cameron, Fergus J., Craig, Maria E., Couper, Jennifer J., Davis, Elizabeth A., Dalton, R. Neil, Daneman, Denis, Donaghue, Kim C., Jones, Timothy W., Mahmud, Farid H., Marshall, Sally M., Neil, H. Andrew W., Dunger, David B., Deanfield, John E.

“…An increased albumin-creatinine ratio within the normal range can identify adolescents at higher risk of developing adverse cardio-renal outcomes as they…”
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Effect of atorvastatin on glycaemia progression in patients with diabetes: an analysis from the Collaborative Atorvastatin in Diabetes Trial (CARDS) by Livingstone, Shona J., Looker, Helen C., Akbar, Tahira, Betteridge, D. John, Durrington, Paul N., Hitman, Graham A., Neil, H. Andrew W., Fuller, John H., Colhoun, Helen M.

“…Aims/hypothesis In an individual-level analysis we examined the effect of atorvastatin on glycaemia progression in type 2 diabetes and whether glycaemia…”
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Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes by Niechciał, Elżbieta, Acerini, Carlo L, Chiesa, Scott T, Stevens, Tracey, Dalton, R Neil, Daneman, Denis, Deanfield, John E, Jones, Timothy W, Mahmud, Farid H, Marshall, Sally M, Neil, H Andrew W, Dunger, David B, Marcovecchio, M Loredana

“…Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to…”
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A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia by Marks, Dalya, Thorogood, Margaret, Neil, H.Andrew W, Humphries, Steve E

“…Background: Familial hypercholesterolaemia (FH) affects approximately 1 in 500 people (10 million world-wide) and the elevated serum cholesterol concentrations…”
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Poor prognosis of young adults with type 1 diabetes: A longitudinal study by BRYDEN, Kathryn S, DUNGER, David B, MAYOU, Richard A, PEVELER, Robert C, NEIL, H. Andrew W

“…To determine the role of early behavioral and psychological factors on later outcomes in young adults with childhood- or adolescent-onset type 1 diabetes. We…”
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Development of sensitive and specific age- and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial hypercholesterolaemia in cascade testing by Starr, Brian, Hadfield, S Gaye, Hutten, Barbara A, Lansberg, Peter J, Leren, Trond P, Damgaard, Dorte, Neil, H Andrew W, Humphries, Steve E

“…The plasma total and low-density lipoprotein-cholesterol (LDL-C) levels that are used as diagnostic criteria for familial hypercholesterolaemia (FH) probands…”
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