Search Results - "Neikes, Hannah K."

Retinoic acid signaling drives differentiation toward the absorptive lineage in colorectal cancer by Wester, Roelof A., van Voorthuijsen, Lisa, Neikes, Hannah K., Dijkstra, Jelmer J., Lamers, Lieke A., Frölich, Siebren, van der Sande, Maarten, Logie, Colin, Lindeboom, Rik G.H., Vermeulen, Michiel

“…Retinoic acid (RA) signaling is an important and conserved pathway that regulates cellular proliferation and differentiation. Furthermore, perturbed RA…”
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Quantifying genome-wide transcription factor binding affinities for chromatin using BANC-seq by Wester, Roelof A, Neikes, Hannah K, Lindeboom, Rik G H, Vermeulen, Michiel

“…Transcription factors (TFs) bind specific DNA sequences to regulate transcription. Apart from DNA sequences, local factors such as DNA accessibility and…”
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PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1 by Glancy, Eleanor, Wang, Cheng, Tuck, Ellen, Healy, Evan, Amato, Simona, Neikes, Hannah K., Mariani, Andrea, Mucha, Marlena, Vermeulen, Michiel, Pasini, Diego, Bracken, Adrian P.

“…Polycomb repressive complex 2 (PRC2) mediates H3K27me3 deposition, which is thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins…”
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Multiomics of Colorectal Cancer Organoids Reveals Putative Mediators of Cancer Progression Resulting from SMAD4 Inactivation by Dijkstra, Jelmer J., Neikes, Hannah K., Rezaeifard, Somayeh, Ma, Xuhui, Voest, Emile E., Tauriello, Daniele V. F., Vermeulen, Michiel

“…The development of metastasis severely reduces the life expectancy of patients with colorectal cancer (CRC). Although loss of SMAD4 is a key event in CRC…”
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ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study by Luna Velez, Maria V, Neikes, Hannah K, Snabel, Rebecca R, Quint, Yarah, Qian, Chen, Martens, Aniek, Veenstra, Gert Jan C, Freeman, Michael R, van Heeringen, Simon J, Vermeulen, Michiel

“…Microfold (M) cells reside in the intestinal epithelium of Peyer's patches (PP). Their unique ability to take up and transport antigens from the intestinal…”
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Quantification of absolute transcription factor binding affinities in the native chromatin context using BANC-seq by Neikes, Hannah K., Kliza, Katarzyna W., Gräwe, Cathrin, Wester, Roelof A., Jansen, Pascal W. T. C., Lamers, Lieke A., Baltissen, Marijke P., van Heeringen, Simon J., Logie, Colin, Teichmann, Sarah A., Lindeboom, Rik G. H., Vermeulen, Michiel

“…Transcription factor binding across the genome is regulated by DNA sequence and chromatin features. However, it is not yet possible to quantify the impact of…”
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PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation by Healy, Evan, Mucha, Marlena, Glancy, Eleanor, Fitzpatrick, Darren J., Conway, Eric, Neikes, Hannah K., Monger, Craig, Van Mierlo, Guido, Baltissen, Marijke P., Koseki, Yoko, Vermeulen, Michiel, Koseki, Haruhiko, Bracken, Adrian P.

“…Polycomb repressive complex 2 (PRC2) is composed of EED, SUZ12, and EZH1/2 and mediates mono-, di-, and trimethylation of histone H3 at lysine 27. At least two…”
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Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma by Pandey, Gaurav Kumar, Landman, Nick, Neikes, Hannah K., Hulsman, Danielle, Lieftink, Cor, Beijersbergen, Roderick, Kolluri, Krishna Kalyan, Janes, Sam M., Vermeulen, Michiel, Badhai, Jitendra, van Lohuizen, Maarten

“…More than half of patients with malignant mesothelioma show alterations in the BAP1 tumor-suppressor gene. Being a member of the Polycomb repressive…”
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Measuring the impact of chromatin context on transcription factor binding affinities

“…We have designed a method, binding affinities to native chromatin by sequencing (BANC-seq), to determine the transcription factor concentrations required for…”
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EZH1-PRC2 Identifies a Potential Reservoir for Disease Relapse in Quiescent Cancer Cells Refractory to EZH2 Enzymatic Inhibition by Healy, Evan, McCole, Rachel, Monger, Craig, Nolan, James, Conway, Eric, Brien, Gerard, Wang, Cheng, Neikes, Hannah K, Potjewyd, Frances, Vermeulen, Michiel, Mooney, Aoibhinn, Flavin, Richard, Vandenberghe, Elisabeth, James, Lindsey I, Bracken, Adrian P

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