Search Results - "Neichi, T."

Long-term production of erythropoietin after electroporation-mediated transfer of plasmid DNA into the muscles of normal and uremic rats by MARUYAMA, H, ATAKA, K, KIKUCHI, H, SUGAWA, M, MIYAZAKI, J, GEJYO, F, HIGUCHI, N, ITO, Y, HIRAHARA, H, IMAZEKI, I, HIRATA, M, ICHIKAWA, F, NEICHI, T

“…The anemia associated with chronic renal failure is one of the best target diseases for erythropoietin (Epo) gene transfer. We previously reported a short-term…”
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Post-secretion neutralization of transgene-derived effect: soluble erythropoietin receptor/IgG1Fc expressed in liver neutralizes erythropoietin produced in muscle by Maruyama, H., Higuchi, M., Higuchi, N., Kameda, S., Saito, M., Sugawa, M., Matsuzaki, J., Neichi, T., Yokoyama, S., Miyazaki, Y., Miyazaki, J., Gejyo, F.

“…Background The regulation of transgene expression is a key issue for the development of safe gene therapy. Various strategies have been used to regulate…”
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In vitro regulatory mechanisms for cytoplasmic maturation of murine megakaryocytes derived from colony-forming units megakaryocyte (CFU-M) by Nagasawa, T, Neichi, T, Satoh, K, Nakazawa, M, Abe, T

“…We studied the effects of recombinant erythropoietin (r-Epo) and thrombocytopenic serum (TS) on the cytoplasmic maturation of megakaryocytes derived from…”
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Possible mechanisms of 15-hydroperoxyarachidonic acid-induced contraction of the canine basilar artery in vitro by Koide, T, Neichi, T, Takato, M, Matsushita, H, Sugioka, K, Nakano, M, Hata, S

“…Pharmacological studies of the contraction induced by 15-hydroperoxyarachidonic acid (15-HPAA) were done in the isolated canine basilar artery. The maximal…”
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Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea–hypopnea syndrome by Imagawa, Shigehiko, Yamaguchi, Yuji, Higuchi, Masato, Neichi, Tomohiro, Hasegawa, Yuichi, Mukai, Harumi Y., Suzuki, Norio, Yamamoto, Masayuki, Nagasawa, Toshiro

“…To better understand how humans adapt to hypoxia, the levels of hemoglobin (Hb), serum erythropoietin (Epo), and vascular endothelial growth factor (VEGF) were…”
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Effects of erythropoietin-gene electrotransfer in rats with adenine-induced renal failure by Ataka, Ken, Maruyama, Hiroki, Neichi, Tomohiro, Miyazaki, Jun-ichi, Gejyo, Fumitake

“…We previously demonstrated that erythropoietin (Epo) expression increases in five-sixths nephrectomized rats, after muscle-targeted gene transfer by in vivo…”
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Comparison of prostaglandin biosynthetic activity between porcine aortic endothelial and smooth muscle cells in culture by Neichi, T, Chang, W C, Mitsui, Y, Murota, S

“…Prostaglandin biosynthetic activity of miniature-pig aortic endothelial cells was compared with that of smooth muscle cells in culture. When used as…”
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Sustained Transgene Expression in Rat Kidney with Naked Plasmid DNA and PCR-Amplified DNA Fragments by Maruyama, Hiroki, Higuchi, Noboru, Kameda, Shigemi, Nakamura, Gen, Shimotori, Masaaki, Iino, Noriaki, Higuchi, Masato, Neichi, Tomohiro, Yokoyama, Sadaaki, Kono, Toru, Miyazaki, Jun-ichi, Gejyo, Fumitake

“…Recently, we developed a kidney-targeted gene transfer technique, in which naked DNA was injected into the renal vein while the renal vein and artery were…”
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Post‐secretion neutralization of transgene‐derived effect: soluble erythropoietin receptor/IgG 1 Fc expressed in liver neutralizes erythropoietin produced in muscle by Maruyama, H., Higuchi, M., Higuchi, N., Kameda, S., Saito, M., Sugawa, M., Matsuzaki, J., Neichi, T., Yokoyama, S., Miyazaki, Y., Miyazaki, J., Gejyo, F.

“…Abstract Background The regulation of transgene expression is a key issue for the development of safe gene therapy. Various strategies have been used to…”
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L-arginine rescues decreased erythropoietin gene expression by stimulating GATA-2 with L-NMMA by IMAGAWA, Shigehiko, TARUMOTO, Takahisa, SUZUKI, Norio, MUKAI, Harumi Y, HASEGAWA, Yuichi, HIGUCHI, Masato, NEICHI, Tomohiro, OZAWA, Keiya, YAMAMOTO, Masayuki, NAGASAWA, Toshiro

“…NG-monomethyl-L-arginine (L-NMMA) decreases the expression of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) and increases the expression of…”
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Post-secretion neutralization of transgene-derived effect: soluble erythropoietin receptor/IgG sub(1)Fc expressed in liver neutralizes erythropoietin produced in muscle by Maruyama, H, Higuchi, M, Higuchi, N, Kameda, S, Saito, M, Sugawa, M, Matsuzaki, J, Neichi, T, Yokoyama, S, Miyazaki, Y, Miyazaki, J, Gejyo, F

“…The regulation of transgene expression is a key issue for the development of safe gene therapy. Various strategies have been used to regulate protein…”
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Effects of AVS (1,2-bis(nicotinamido)propane) on platelet function and vascular endothelium by Mizukami, M, Neichi, T, Yamazaki, T, Koide, T, Noda, Y, Matsushita, H, Hata, S, Nakano, M

“…The effects of 1,2-bis(nicotinamido)propane (AVS) on platelet function and vascular endothelium were investigated using various experimental thrombosis and…”
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Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis by Neichi, T, Koshihara, Y, Murota, S

“…Esculetin (6,7-dihydroxycoumarin) showed inhibitory effects on 5- and 12-lipoxygenases of cloned mastocytoma cells. The half-inhibition dose (ID50) for each…”
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Caffeic acid is a selective inhibitor for leukotriene biosynthesis by Koshihara, Y, Neichi, T, Murota, S, Lao, A, Fujimoto, Y, Tatsuno, T

“…eukotrienes are significantly involved in immunoregulation and in a variety of diseases, including asthma, inflammation and various allergic conditions. They…”
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Thrombopoietic activity of human interleukin-6 by Nagasawa, Toshiro, Orita, Tetsuro, Matsushita, Jun-ichi, Tsuchiya, Masayuki, Neichi, Tomohiro, Imazeki, Ikuo, Imai, Nobuo, Ochi, Norimichi, Kanma, Hiroshi, Abe, Tsukasa

“…Thrombopoietin (TPO), a regulatory factor in platelet production, was purified from the conditioned medium of TNK-01 cells cultured in the presence of human…”
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Selective inhibition of 5-lipoxygenase by natural compounds isolated from Chinese plants, Artemisia rubripes Nakai by Koshihara, Yasuko, Neichi, Tomohiro, Murota, Sei-itsu, Lao, Ai-na, Fujimoto, Yasuo, Tatsuno, Takashi

“…Three of four natural compounds, which are caffeic acid, eupatilin and 4′-demethyleupatilin, isolated from Chinese plant, Artemisia rubripes Nakai selectively…”
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Enhancement of PGI2 formation by a new vasodilator, 2-nicotinamidoethyl nitrate in the coupled system of platelets and aortic microsomes by Neichi, T, Tomisawa, S, Kubodera, N, Uchida, Y

“…Exogenous arachidonate addition to the coupled system of platelets and aortic microsomes resulted in production of TXA2 and PGI2 (detected as the stable…”
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Effects of estradiol on the metabolism of arachidonic acid by aortas and platelets in rats by Chang, W C, Nakao, J, Neichi, T, Orimo, H, Murota, S

“…We have previously reported that estradiol treatment stimulates prostacyclin production by cultured rat aortic smooth muscle cells, through the stimulation of…”
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The lipid-lowering profile in rodents. AZ-1355, a new dibenzoxazepine derivative by Wada, S, Koizumi, M, Sasahara, K, Neichi, T, Nakakimura, H, Onoda, F, Hata, S I

“…The lipid-lowering profile of ethyl 10,11-dihydro-4-methoxydibenz[b,f]-(1,4)oxazepine-8-carboxylate (AZ-1355) has been evaluated using clofibrate as a…”
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