Mismatch Negativity Recording in Children With Duchenne Muscular Dystrophy: A Preliminary Study Integrating Neurophysiological and Neuropsychological Results

Mismatch Negativity Recording in Children With Duchenne Muscular Dystrophy A Preliminary Study Integrating Neurophysiological and Neuropsychological Results

Many studies on Duchenne muscular dystrophy children support the hypothesis of a specific neuropsychological phenotype affecting mostly phonological skills. This prospective study aimed to shed light on the role of phonological abilities. Fourteen Duchenne muscular dystrophy children and 7 healthy c...

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Bibliographic Details
Published in:Journal of child neurology Vol. 31; no. 13; pp. 1468 - 1474
Main Authors: Filippini, Melissa, Guerra, Angelo, Negosanti, Alessandra, Santi, Sara, Sarajlija, Jasenka, Musti, Muriel Assunta, Gobbi, Giuseppe, Lassonde, Maryse, Pini, Antonella
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 01-11-2016
Subjects:
Adolescent
Brain - physiopathology
Child
Child, Preschool
Electroencephalography
Humans
Male
Models, Neurological
Models, Psychological
Muscular Dystrophy, Duchenne - physiopathology
Muscular Dystrophy, Duchenne - psychology
Neuropsychological Tests
Prospective Studies
Speech Perception - physiology
mismatch negativity
neuropsychological profile
phonological hypothesis
Duchenne muscular dystrophy
cerebellar hypothesis
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Summary:Many studies on Duchenne muscular dystrophy children support the hypothesis of a specific neuropsychological phenotype affecting mostly phonological skills. This prospective study aimed to shed light on the role of phonological abilities. Fourteen Duchenne muscular dystrophy children and 7 healthy children underwent mismatch negativity. Moreover, verbal intelligence, visuospatial attention, immediate verbal memory, working memory, grammar, vocabulary, visuomotor skills, reading, text comprehension, writing, and arithmetic were tested in Duchenne muscular dystrophy children. No significant difference between control and Duchenne muscular dystrophy children was found neither for mismatch negativity amplitude (P = .191 and .116, respectively) nor for latency (P = .135). Eight (57.14%) patients showed an impairment of immediate verbal memory and of visuomotor skills, 7 (63.64%) patients had a deficit in writing and arithmetic skills, even with a mean normal intelligence quotient. Taken together, the results put in evidence a heterogeneous neuropsychological profile not explainable on the basis of a phonological deficit.
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ISSN:0883-0738
1708-8283
DOI:10.1177/0883073816656404