Search Results - "Negi, Riya"

Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time by Kenny, Grace, O’Reilly, Sophie, Wrigley Kelly, Neil, Negi, Riya, Gaillard, Colette, Alalwan, Dana, Saini, Gurvin, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, Garcia Leon, Alejandro Abner, Tinago, Willard, Feeney, Eoin R., Cotter, Aoife G., de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Doran, Peter, Stemler, Jannik, Koehler, Philipp, Cox, Rebecca Jane, O’Shea, Donal, Olesen, Ole F., Landay, Alan, Hogan, Andrew E., Lelievre, Jean-Daniel, Gautier, Virginie, Cornely, Oliver A., Mallon, Patrick W. G.

“…SARS-CoV-2 neutralising antibodies provide protection against COVID-19. Evidence from early vaccine trials suggested binding antibody thresholds could serve as…”
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Early inflammatory profiles predict maximal disease severity in COVID-19: An unsupervised cluster analysis by Kenny, Grace, Saini, Gurvin, Gaillard, Colette Marie, Negi, Riya, Alalwan, Dana, Garcia Leon, Alejandro, McCann, Kathleen, Tinago, Willard, Kelly, Christine, Cotter, Aoife G., de Barra, Eoghan, Horgan, Mary, Yousif, Obada, Gautier, Virginie, Landay, Alan, McAuley, Danny, Feeney, Eoin R., O'Kane, Cecilia, Mallon, Patrick WG

“…The inflammatory changes that underlie the heterogeneous presentations of COVID-19 remain incompletely understood. In this study we aimed to identify…”
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Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021 by Funk, Tjede, Pharris, Anastasia, Spiteri, Gianfranco, Bundle, Nick, Melidou, Angeliki, Carr, Michael, Gonzalez, Gabriel, Garcia-Leon, Alejandro, Crispie, Fiona, O'Connor, Lois, Murphy, Niamh, Mossong, Joël, Vergison, Anne, Wienecke-Baldacchino, Anke K, Abdelrahman, Tamir, Riccardo, Flavia, Stefanelli, Paola, Di Martino, Angela, Bella, Antonino, Lo Presti, Alessandra, Casaca, Pedro, Moreno, Joana, Borges, Vítor, Isidro, Joana, Ferreira, Rita, Gomes, João Paulo, Dotsenko, Liidia, Suija, Heleene, Epstein, Jevgenia, Sadikova, Olga, Sepp, Hanna, Ikonen, Niina, Savolainen-Kopra, Carita, Blomqvist, Soile, Möttönen, Teemu, Helve, Otto, Gomes-Dias, Joana, Adlhoch, Cornelia

“…We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European…”
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Biomarker associations with insomnia and secondary sleep outcomes in persons with and without HIV in the POPPY-Sleep substudy: a cohort study by Bakewell, Nicholas, Sabin, Caroline A, Negi, Riya, Garcia-Leon, Alejandro, Winston, Alan, Sachikonye, Memory, Doyle, Nicki, Redline, Susan, Mallon, Patrick W G, Kunisaki, Ken M

“…Abstract Study Objectives We investigated associations between inflammatory profiles/clusters and sleep measures in people living with HIV and…”
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Associations between host microbiome and inflammation suggest role for host microbiome in driving COVID-19 disease severity by MacCann, Rachel, Ghosh, Tarini Shankar, Garcia Leon, Alejandro Abner, Li, Junhui, Negi, Riya, Gaillard, Colette, Saini, Gurvin, Tinago, Willard, Feeney, Eoin R., Yousif, Obada, Cotter, Aoife G., de Barra, Eoghan, Sadlier, Corinna, Doran, Peter, Landay, Alan, O'Toole, Paul W., Mallon, Patrick W.

“…Systemic inflammation and innate immune activation are associated with COVID-19 disease severity. Knowledge gaps remain in the relationships between…”
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Performance and validation of an adaptable multiplex assay for detection of serologic response to SARS-CoV-2 infection or vaccination by Kenny, Grace, Negi, Riya, O'Reilly, Sophie, Garcia-Leon, Alejandro, Alalwan, Dana, Gaillard, Colette Marie, Saini, Gurvin, Inzitari, Rosana, Feeney, Eoin R., Yousif, Obada, Cotter, Aoife G, de Barra, Eoghan, Sadlier, Corinna, Crispie, Fiona, Doran, Peter, Gautier, Virginie, Mallon, Patrick W.G.

“…Measurement of quantitative antibody responses are increasingly important in evaluating the immune response to infection and vaccination. In this study we…”
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Immunogenicity and reactogenicity of a first booster with BNT162b2 or full-dose mRNA-1273: A randomised VACCELERATE trial in adults ≥75 years (EU-COVAT-1) by Neuhann, Julia M., Stemler, Jannik, Carcas, Antonio J., Frías-Iniesta, Jesús, Akova, Murat, Bethe, Ullrich, Heringer, Sarah, Salmanton-García, Jon, Tischmann, Lea, Zarrouk, Marouan, Cüppers, Arnd, Grothe, Jan, Leon, Alejandro Garcia, Mallon, Patrick, Negi, Riya, Gaillard, Colette, Saini, Gurvin, Lammens, Christine, Hotterbeekx, An, Loens, Katherine, Malhotra-Kumar, Surbhi, Goossens, Herman, Kumar-Singh, Samir, König, Franz, Yeghiazaryan, Lusine, Posch, Martin, Koehler, Philipp, Cornely, Oliver A.

“…Vaccination remains crucial for protection against severe SARS-CoV-2 infection, especially for people of advanced age, however, optimal dosing regimens are as…”
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Impact of vaccination and variants of concern on long COVID clinical phenotypes by Kenny, Grace, McCann, Kathleen, O'Brien, Conor, O'Broin, Cathal, Tinago, Willard, Yousif, Obada, O'Gorman, Tessa, Cotter, Aoife G, Lambert, John S, Feeney, Eoin R, de Barra, Eoghan, Sadlier, Corinna, Landay, Alan, Doran, Peter, Savinelli, Stefano, Mallon, Patrick W. G, MacCann, Rachel, Garcia Leon, Alejandro, Miles, Sarah, Alalwan, Dana, Negi, Riya, Muldoon, Eavan, Sheehan, Gerard, McGinty, Tara, Green, Sandra, Leamy, Kelly, Kelly, Christine, de Barra, Eoin, McConkey, Samuel, Hurley, Killain, Sulaiman, Imran, Horgan, Mary, Eustace, Joseph, Bracken, Tommy, Whelan, Bryan, Low, Justin, McNicholas, Bairbre, Courtney, Garry, Gavin, Patrick

“…Abstract Background Defining patterns of symptoms in long COVID is necessary to advance therapies for this heterogeneous condition. Here we aimed to describe…”
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Immunogenicity, reactogenicity, and safety of a second booster with BNT162b2 or full-dose mRNA-1273: A randomized VACCELERATE trial in adults aged ≥75 years (EU-COVAT-1-AGED Part B) by Stemler, Jannik, Yeghiazaryan, Lusine, Stephan, Christoph, Mohn, Kristin Greve-Isdahl, Carcas-Sansuan, Antonio-José, Rodriguez, Esperanza Romero, Moltó, José, Mitxeltorena, Itziar Vergara, Welte, Tobias, Zablockienė, Birutė, Akova, Murat, Bethe, Ullrich, Heringer, Sarah, Salmanton-García, Jon, Jeck, Julia, Tischmann, Lea, Zarrouk, Marouan, Cüppers, Arnd, Biehl, Lena M., Grothe, Jan, Mellinghoff, Sibylle C., Nacov, Julia A., Neuhann, Julia M., Sprute, Rosanne, Frías-Iniesta, Jesús, Negi, Riya, Gaillard, Colette, Saini, Gurvin, León, Alejandro García, Mallon, Patrick W.G., Lammens, Christine, Hotterbeekx, An, Loens, Katherine, Malhotra-Kumar, Surbhi, Goossens, Herman, Kumar-Singh, Samir, König, Franz, Posch, Martin, Koehler, Philipp, Cornely, Oliver A.

“…•This was a randomized trial of second messenger RNA SARS-CoV-2 booster in very advanced aged (mean 81 years) participants.•Two-fold anti-receptor binding…”
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1346. Genetic Variation at the Interferon λ Locus and Association with Clinical Outcome and Severity of COVID-19 by Alalwan, Dana, Negi, Riya, García-León, Alejandro, Saini, Gurvin, Gaillard, Colette Marie, Kenny, Grace, Savinelli, Stefano, Feeney, Eoin R, Cotter, Aoife, Carr, Michael, Gonzalez, Gabriel, Landay, Alan, de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Mallon, Patrick

“…Abstract Background People with obesity are at increased risk of severe COVID-19, with host inflammation a key contributor. Interferon (IFN) lambda 4 (IFNλ4)…”
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312. Performance and validation of an adaptable multiplex assay for detection of serologic response to SARS-CoV-2 infection or vaccination by Kenny, Grace, O’Reilly, Sophie R, Negi, Riya, Garcia-Leon, Alejandro, Alalwan, Dana, Gaillard, Colette Marie, Saini, Gurvin, Inzitari, Rosanna, Feeney, Eoin, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Sadlier, Corinna, Crispie, Fiona, Doran, Peter, Gautier, Virginie, Mallon, Patrick, BCh, M B

“…Abstract Background A wide array of assays to detect the serologic response to SARS-CoV-2 have been developed since the emergence of the pandemic. The majority…”
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2356. Close correlation of RBD with Live Viral Neutralising Capacity Across Variants and Time Supports Use of RBD Thresholds to Predict Protective Host Immunity by Kenny, Grace, O’Reilly, Sophie R, Kelly, Neil Wrigley, Negi, Riya, Gaillard, Colette Marie, Alalwan, Dana, Saini, Gurvin, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, García-León, Alejandro, Tinago, Willard, Feeney, Eoin R, Cotter, Aoife, de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Doran, Peter, Cox, Rebecca J, O’Shea, Donal, Olesen, Ole, Landay, Alan, Hogan, Andrew, Lelièvre, Jean-Daniel, Gautier, Virginie, Cornely, Oliver A, Mallon, Patrick

“…Abstract Background Although SARS-CoV-2 neutralising antibodies protect against severe COVID-19, whether circulating IgG titres reflect underlying host…”
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2338. Robust and Persistent B Cell Responses Following Third Dose SARS-CoV-2 Vaccine Determine Protection from COVID-19 by Byrne, Joanne, Gu, Lili, García-León, Alejandro, Gaillard, Colette Marie, Tomás-Cortázar, Julen, Negi, Riya, Alalwan, Dana, Saini, Gurvin, Donohue, Sean, Reynolds, Bearach, Kenny, Grace, Leamy, Kelly, O’Gorman, Tessa, O’Broin, Cathal, Savinelli, Stefano, Feeney, Eoin R, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Sadlier, Corinna, Landay, Alan, Doran, Peter, Cox, Rebecca J, Olesen, Ole, Lelièvre, Jean-Daniel, Cornely, Oliver A, Gautier, Virginie, Mallon, Patrick

“…Abstract Background The immunological memory to SARS-CoV-2 (SCV-2) vaccination has multiple components, with robust antibody (Ab) and B cell responses…”
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1959. Lower B-Cell Responses Rather Than Circulating Antibody Titres Are Associated With SARS-CoV-2 Infection Post Third Dose COVID-19 Vaccination by Byrne, Joanne, Gu, Lili, Negi, Riya, Garcia-Leon, Alejandro, Alalwan, Dana, Gaillard, Colette Marie, Saini, Gurvin, Leamy, Kelly, Reynolds, Bearach, O’Gorman, Tessa, Kenny, Grace, O’Broin, Cathal, Feeney, Eoin R, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Horgan, Mary, Landay, Alan, Doran, Peter, Gautier, Virginie, Mallon, Patrick

“…Abstract Background Which components of the immune response to SARS-CoV-2 vaccination best protect against subsequent infection remains unclear. We explored…”
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