Search Results - "Neff, N H"

GM1 Ganglioside: In Vivo and In Vitro Trophic Actions on Central Neurotransmitter Systems by Hadjiconstantinou, Maria, Neff, Norton H.

“…: There is now substantial evidence that GM1 ganglioside is effective in partially correcting the consequences of neuroinjury in a number of in vivo and in…”
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Protein kinase C activators decrease dopamine uptake into striatal synaptosomes by Copeland, B J, Vogelsberg, V, Neff, N H, Hadjiconstantinou, M

“…Incubation with either of the protein kinase C activators phorbol 12-myristate 13-acetate (PMA) and sn-1,2 dioctanoylglycerol (DiC8) decreased the uptake of…”
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GM1 enhances dopaminergic markers in the brain of aged rats by Goettl, V.M, Zhang, H, Burrows, A.C, Wemlinger, T.A, Neff, N.H, Hadjiconstantinou, M

“…A number of presynaptic markers are compromised in the dopaminergic neurons of aged Sprague–Dawley rats (22 months old) compared with young rats (3 months…”
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Nicotine abstinence in the mouse by Isola, Raffaella, Vogelsberg, Vanessa, Wemlinger, Trina A., Neff, Norton H., Hadjiconstantinou, Maria

“…We present evidence that intermittent administration of nicotine, 2 mg/kg s.c., four times daily to mice for 14 days produces a somatic abstinence syndrome…”
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Aromatic L-amino acid decarboxylase activity of mouse striatum is modulated via dopamine receptors by Hadjiconstantinou, M, Wemlinger, T A, Sylvia, C P, Hubble, J P, Neff, N H

“…Aromatic L-amino acid decarboxylase (AAAD) activity is enhanced in the striatum of control and MPTP-treated mice after administration of a single dose of the…”
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Cyclic AMP‐Mediated Enhancement of High‐Affinity Choline Transport and Acetylcholine Synthesis in Brain by Vogelsberg, V., Neff, N. H., Hadjiconstantinou, M.

“…: Intracerebroventricular administration of N6, 2′‐O‐dibutyryladenosine 3′,5′‐cyclic monophosphate (db‐cyclic AMP) to mice increased high‐affinity choline…”
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Regulation of tyrosine hydroxylase and aromatic l-amino acid decarboxylase by dopaminergic drugs by Cho, Seongeun, Neff, Norton H, Hadjiconstantinou, Maria

“…We provide evidence that dopamine receptors differentially modulate tyrosine hydroxylase and aromatic l-amino acid decarboxylase in the mouse striatum. The…”
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Evidence for cyclic AMP-mediated increase of aromatic L-amino acid decarboxylase activity in the striatum and midbrain by Young, E A, Neff, N H, Hadjiconstantinou, M

“…Aromatic L-amino acid decarboxylase (AAAD) activity of mouse striatum and midbrain increased after an intracerebroventricular injection of either forskolin or…”
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GM1 ganglioside restores dopaminergic neurochemical and morphological markers in aged rats by Goettl, V.M., Wemlinger, T.A., Duchemin, A.-M., Neff, N.H., Hadjiconstantinou, M.

“…The monosialoganglioside GM1 exerts neurotrophic-like activity in vitro and in vivo. In particular, it improves cholinergic neuron morphology and chemistry and…”
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Phosphorylation and Activation of Brain Aromatic l‐Amino Acid Decarboxylase by Cyclic AMP‐Dependent Protein Kinase by Duchemin, Anne‐Marie, Berry, Mark D, Neff, Norton H, Hadjiconstantinou, Maria

“…Aromatic l‐amino acid decarboxylase (AAAD), an enzyme required for the synthesis of catecholamines, indoleamines, and trace amines, is rapidly activated by…”
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Nicotine-induced changes of brain β-endorphin by Gudehithlu, K.P, Duchemin, A.-M, Tejwani, G.A, Neff, N.H, Hadjiconstantinou, M

“…Abstract A consensus has emerged that endogenous opioid peptides and their receptors play an important role in the psychoactive properties of nicotine…”
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Treatment with GM1 ganglioside restores striatal dopamine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse by Hadjiconstantinou, M, Neff, N H

“…1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 30 mg/kg i.p. daily for 7 days, was administered to mice. This dosage regimen resulted in an approximately…”
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gamma-aminobutyric acid B receptors are negatively coupled to adenylate cyclase in brain, and in the cerebellum these receptors may be associated with granule cells by Wojcik, W J, Neff, N H

“…Baclofen and gamma-aminobutyric acid (GABA) are shown to inhibit basal adenylate cyclase activity in brain of rat. The response is mediated through the GABAB…”
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SCH 23390 enhances exogenous L-DOPA decarboxylation in nigrostriatal neurons by NEFF, N. H, WEMLINGER, T. A, HADJICONSTANTINOU, M

“…Exogenous L-DOPA enhances dopamine metabolism in the intact and denervated striatum, and is the treatment of choice for Parkinsonism. Aromatic L-amino acid…”
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Tyrosine hydroxylase, aromatic l-amino acid decarboxylase and dopamine metabolism after chronic treatment with dopaminergic drugs by Cho, Seongeun, Duchemin, Anne-Marie, Neff, Norton H, Hadjiconstantinou, Maria

“…Mice were treated with dopamine (DA) receptor agonist and antagonist drugs: Agonists: (±)-SKF 38393…”
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GM1 ganglioside improves dopaminergic markers of rat mesencephalic cultures treated with MPP by Dalia, A, Neff, NH, Hadjiconstantinou, M

“…Rat embryonic mesencephalic cultures were employed to evaluate the consequences of adding GM1 ganglioside to cultures lesioned with the selective neurotoxin…”
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Enhanced MPTP neurotoxicity after treatment with isoflurophate or cholinergic agonists by Hadjiconstantinou, M, Hubble, J P, Wemlinger, T A, Neff, N H

“…Administration of the irreversible cholinesterase inhibitor isoflurophate (diisopropylfluorophosphate, DFP) before 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine…”
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Phorbol ester administration transiently increases aromatic L-amino acid decarboxylase activity of the mouse striatum and midbrain by Young, E A, Neff, N H, Hadjiconstantinou, M

“…Aromatic L-amino acid decarboxylase (AAAD) is required for the synthesis of catecholamines, serotonin, and the trace amines. We found that the protein kinase C…”
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Glutamate, glutamine and glutamine synthetase in the neonatal rat brain following hypoxia by Krajnc, Dimitri, Norton, H.Neff, Hadjiconstantinou, Maria

“…Exposing 7-day-old rat pups to hypoxia, 8% oxygen/92% nitrogen, for 3 h alters glutamate (GLU), glutamine and glutamine synthetase (GS) activity in the…”
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GM1 and NGF synergism on choline acetyltransferase and choline uptake in aged brain by Fong, T.G., Vogelsberg, V., Neff, N.H., Hadjiconstantinou, M.

“…In the brain of aged rats high affinity choline uptake (HAChU) of the striatum, hippocampus, and frontal cortex is lower than in young rats, while choline…”
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