Search Results - "Neer, E.J."

Specificity of G protein beta and gamma subunit interactions by SCHMIDT, C. J, THOMAS, T. C, LEVINE, M. A, NEER, E. J

“…Multiple heterotrimeric guanine nucleotide binding protein (G protein) subunits have evolved to couple a large variety of receptors to intracellular effectors…”
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Promotion of the GTP-liganded state of the Go alpha protein by deletion of the C terminus by DENKER, B. M, SCHMIDT, C. J, NEER, E. J

“…G proteins are active as long as GTP is bound to the alpha subunit. Activation ends when GTP is cleaved to GDP that then stays bound to the active site…”
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Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions by Denker, B M, Neer, E J, Schmidt, C J

“…Heterotrimeric guanine nucleotide-binding proteins are composed of alpha and beta gamma subunits and couple a variety of cell-surface receptors to…”
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Dilated Cardiomyopathy in Two Transgenic Mouse Lines Expressing Activated G Protein αq: Lack of Correlation Between Phospholipase C Activation and the Phenotype by Mende, U., Semsarian, C., Martins, D.C., Kagen, A., Duffy, C., Schoen, F.J., Neer, E.J.

“…We previously described a transgenic mouse line (αq*52) in which cardiac-specific expression of activated G αqprotein (HA αq*) leads to activation of…”
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A 14-amino acid region of the G protein gamma subunit is sufficient to confer selectivity of gamma binding to the beta subunit by Spring, D J, Neer, E J

“…Heterotrimeric guanine nucleotide-binding proteins are important signaling molecules composed of an alpha, beta, and gamma subunit. The beta subunits must form…”
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Reactive sulfhydryl groups of alpha 39, a guanine nucleotide-binding protein from brain. Location and function by Winslow, J.W., Bradley, J.D., Smith, J.A., Neer, E.J.

“…The guanine nucleotide-binding proteins which mediate hormonal inhibition of adenylate cyclase as well as hormonal regulation of other membrane functions are…”
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Expression of a G protein subunit, alpha i-1, in Balb/c 3T3 cells leads to agonist-specific changes in growth regulation by Cui, Z, Zubiaur, M, Bloch, D B, Michel, T, Seidman, J G, Neer, E J

“…Cellular receptors for many hormones, neurotransmitters, and growth factors are coupled to intracellular effector enzymes or ion channels through a set of…”
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Physical and functional properties of adenylate cyclase from mature rat testis by Neer, E J

“…The mature rat testis contains two forms of adenylate cyclase. One is membrane-bound and hormone-responsive; the other is water-soluble and not activated by…”
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Calmodulin activates the isolated catalytic unit of brain adenylate cyclase by Salter, R S, Krinks, M H, Klee, C B, Neer, E J

“…The catalytic and guanine nucleotide regulatory (G/F) units of solubilized bovine brain adenylate cyclase were separated by gel filtration as described by…”
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Interaction of soluble brain adenylate cyclase with manganese by Neer, E J

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Size and detergent binding of adenylate cyclase from bovine cerebral cortex by Neer, E J

“…Adenylate cyclase from the bovine cerebral cortex has been solubilized with the nonionic detergent Triton X-100. The physical properties of the enzyme have…”
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Partial purification and characterization of a pp60v-src-related tyrosine kinase from bovine brain by Neer, E.J, Lok, J.M

“…We have identified and substantially purified a tyrosine protein kinase from normal bovine brain that is immunologically related to the product of the Rous…”
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Identification of cDNA encoding an additional. alpha. subunit of a human GTP-binding protein: Expression of three. alpha. sub i subtypes in human tissues and cell lines by Kim, S., Ang, S.L., Bloch, D.B., Bloch, K.D., Kawahara, Y., Tolman, C., Lee, R., Seidman, J.G., Neer, E.J.

“…The guanine nucleotide-binding proteins (G proteins), which mediate hormonal regulation of many membrane functions, are composed of {alpha}, {beta}, and…”
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Increase in the size of soluble brain adenylate cyclase with activation by guanosine 5'-(beta, gamma-imino)triphosphate by Neer, E J, Echeverria, D, Knox, S

“…Adenylate cyclase solubilized from bovine brain with Lubrol 12A9 or Triton X-100 can be resolved into two forms by gel filtration or sucrose density gradient…”
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Reconstituted adenylate cyclase from bovine brain. Functions of the subunits by Neer, E J, Salter, R S

“…Stimulation of soluble adenylate cyclase by guanosine 5'-( beta , gamma -imino)triphosphate (Gpp(NH)p) requires the interaction of two enzyme components: the…”
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Modification of adenylate cyclase structure and function by ammonium sulfate by Neer, E J, Salter, R S

“…(NH sub(4)) sub(2)SO sub(4) modifies the function and the structure of brain adenylate cyclase. Basal activity and activity with 5 mM Mn super(2+) are…”
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The site of alpha-chymotryptic activation of pigeon erythrocyte adenylate cyclase by Marshak, D R, Neer, E J

“…Treatment of intact pigeon erythrocytes with trypsin or alpha-chymotrypsin does not alter the isoproterenol-dependent adenylate cyclase activity in plasma…”
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Functions of G-protein subunits by Neer, E J, Kim, S Y, Ang, S L, Bloch, D B, Bloch, K D, Kawahara, Y, Tolman, C, Lee, R, Logothetis, D, Kim, D

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