Search Results - "Neely, M."

Scalpels not hammers: The way forward for precision drug prescription by Neely, M

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Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor by Brown, Jacquelyn A, Pensabene, Virginia, Markov, Dmitry A, Allwardt, Vanessa, Neely, M Diana, Shi, Mingjian, Britt, Clayton M, Hoilett, Orlando S, Yang, Qing, Brewer, Bryson M, Samson, Philip C, McCawley, Lisa J, May, James M, Webb, Donna J, Li, Deyu, Bowman, Aaron B, Reiserer, Ronald S, Wikswo, John P

“…The blood-brain barrier (BBB) is a critical structure that serves as the gatekeeper between the central nervous system and the rest of the body. It is the…”
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Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice by Dagher, Nabil N, Najafi, Allison R, Kayala, Kara M Neely, Elmore, Monica R P, White, Terra E, Medeiros, Rodrigo, West, Brian L, Green, Kim N

“…Microglia are dependent upon colony-stimulating factor 1 receptor (CSF1R) signaling for their survival in the adult brain, with administration of the dual…”
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Cobalt Catalyzed Z‑Selective Hydroboration of Terminal Alkynes and Elucidation of the Origin of Selectivity by Obligacion, Jennifer V, Neely, Jamie M, Yazdani, Aliza N, Pappas, Iraklis, Chirik, Paul J

“…A bis­(imino)­pyridine cobalt-catalyzed hydroboration of terminal alkynes with HBPin (Pin = pinacolate) with high yield and (Z)-selectivity for synthetically…”
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Workload assessment of surgeons: correlation between NASA TLX and blinks by Zheng, Bin, Jiang, Xianta, Tien, Geoffrey, Meneghetti, Adam, Panton, O. Neely M., Atkins, M. Stella

“…Background Blinks are known as an indicator of visual attention and mental stress. In this study, surgeons’ mental workload was evaluated utilizing a paper…”
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Mechanisms and Disease Pathogenesis Underlying Metal-Induced Oxidative Stress by Chen, Pan, Bornhorst, Julia, Diana Neely, M., Avila, Daiana S.

“…Excess intracellular RONS eventually disrupts the intracellular redox state and energy production resulting in oxidative stress, which manifests itself in the…”
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The Combination of Fosfomycin plus Meropenem Is Synergistic for Pseudomonas aeruginosa PAO1 in a Hollow-Fiber Infection Model by Drusano, G L, Neely, M N, Yamada, W M, Duncanson, Brandon, Brown, David, Maynard, Michael, Vicchiarelli, Michael, Louie, Arnold

“…Treating high-density bacterial infections is a challenging clinical problem. We have a paucity of new agents that can address this problem. is a particularly…”
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Single cell RNA sequencing detects persistent cell type- and methylmercury exposure paradigm-specific effects in a human cortical neurodevelopmental model by Neely, Maja Diana, Xie, Shaojun, Prince, Lisa M., Kim, Hyunjin, Tukker, Anke M., Aschner, Michael, Thimmapuram, Jyothi, Bowman, Aaron B.

“…The developing human brain is uniquely vulnerable to methylmercury (MeHg) resulting in lasting effects especially in developing cortical structures. Here we…”
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Accelerated differentiation of human induced pluripotent stem cells to blood-brain barrier endothelial cells by Hollmann, Emma K, Bailey, Amanda K, Potharazu, Archit V, Neely, M Diana, Bowman, Aaron B, Lippmann, Ethan S

“…Due to their ability to limitlessly proliferate and specialize into almost any cell type, human induced pluripotent stem cells (iPSCs) offer an unprecedented…”
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From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons by Neely, M Diana, Davison, Carrie Ann, Aschner, Michael, Bowman, Aaron B

“…Parkinson's disease (PD) is the result of complex interactions between genetic and environmental factors. Two chemically distinct environmental stressors…”
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North Pacific Surgical Association Presidential Address 2017- From Cayman to Vancouver: One surgeon's journey by Panton, O. Neely M.

“…This is the Presidential Address at the 104th Annual Meeting of the North Pacific Surgical Association held in Vancouver, BC, Canada, November 10–11, 2017…”
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Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease by Di Pardo, Alba, Amico, Enrico, Basit, Abdul, Armirotti, Andrea, Joshi, Piyush, Neely, M. Diana, Vuono, Romina, Castaldo, Salvatore, Digilio, Anna F., Scalabrì, Francesco, Pepe, Giuseppe, Elifani, Francesca, Madonna, Michele, Jeong, Se Kyoo, Park, Bu-Mahn, D’Esposito, Maurizio, Bowman, Aaron B., Barker, Roger A., Maglione, Vittorio

“…Huntington’s disease is characterized by a complex and heterogeneous pathogenic profile. Studies have shown that disturbance in lipid homeostasis may represent…”
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Impact of Bolus Dosing versus Continuous Infusion of Piperacillin and Tazobactam on the Development of Antimicrobial Resistance in Pseudomonas aeruginosa by FELTON, T. W, GOODWIN, J, O'CONNOR, L, SHARP, A, GREGSON, L, LIVERMORE, J, HOWARD, S. J, NEELY, M. N, HOPE, W. W

“…OA  Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Huntington’s disease associated resistance to Mn neurotoxicity is neurodevelopmental stage and neuronal lineage dependent by Joshi, Piyush, Bodnya, Caroline, Ilieva, Ilyana, Neely, M. Diana, Aschner, Michael, Bowman, Aaron B.

“…•HD genotype was associated with resistance to Mn cytotoxicity in human striatal NPCs, cortical NPCs and hiPSCs.•HD genotype conferred increased sensitivity to…”
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Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit by Brown, Jacquelyn A, Codreanu, Simona G, Shi, Mingjian, Sherrod, Stacy D, Markov, Dmitry A, Neely, M Diana, Britt, Clayton M, Hoilett, Orlando S, Reiserer, Ronald S, Samson, Philip C, McCawley, Lisa J, Webb, Donna J, Bowman, Aaron B, McLean, John A, Wikswo, John P

“…Understanding blood-brain barrier responses to inflammatory stimulation (such as lipopolysaccharide mimicking a systemic infection or a cytokine cocktail that…”
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A cost-conscious establishment of a robotic abdominal wall reconstruction program in a publicly funded healthcare system by Hennessey, Rachel Q. Liu, Yang, Yuwei, Meneghetti, Adam T., Panton, O. Neely M., Chiu, Chieh Jack

“…Purpose Despite reports of better short-term outcomes, the main criticism for the adoption of the robotic surgery platform for abdominal wall reconstruction…”
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Individualization of piperacillin dosing for critically ill patients: dosing software to optimize antimicrobial therapy by Felton, T W, Roberts, J A, Lodise, T P, Van Guilder, M, Boselli, E, Neely, M N, Hope, W W

“…Piperacillin-tazobactam is frequently used for empirical and targeted therapy of infections in critically ill patients. Considerable pharmacokinetic (PK)…”
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Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis by Whitt, Aaron G., Neely, Aaron M., Sarkar, Omar Sadi, Meng, Shuhan, Arumugam, Sengodagounder, Yaddanapudi, Kavitha, Li, Chi

“…Paraoxonase 2 (PON2) is a multifunctional intracellular enzyme that has received growing attention for its ability to modulate various aspects of normal and…”
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A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease by Tidball, Andrew M, Bryan, Miles R, Uhouse, Michael A, Kumar, Kevin K, Aboud, Asad A, Feist, Jack E, Ess, Kevin C, Neely, M Diana, Aschner, Michael, Bowman, Aaron B

“…The essential micronutrient manganese is enriched in brain, especially in the basal ganglia. We sought to identify neuronal signaling pathways responsive to…”
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Why Has Model‐Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the Future by Darwich, A S, Ogungbenro, K, Vinks, A A, Powell, J R, Reny, J‐L, Marsousi, N, Daali, Y, Fairman, D, Cook, J, Lesko, L J, McCune, J S, Knibbe, C A J, Wildt, S N, Leeder, J S, Neely, M, Zuppa, A F, Vicini, P, Aarons, L, Johnson, T N, Boiani, J, Rostami‐Hodjegan, A

“…Patient groups prone to polypharmacy and special subpopulations are susceptible to suboptimal treatment. Refined dosing in special populations is imperative to…”
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