Search Results - "Neel, Nicole F"

LIM and SH3 protein-1 modulates CXCR2-mediated cell migration by Raman, Dayanidhi, Sai, Jiqing, Neel, Nicole F, Chew, Catherine S, Richmond, Ann

“…The chemokine receptor CXCR2 plays a pivotal role in migration of neutrophils, macrophages and endothelial cells, modulating several biological responses such…”
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The RalB Small GTPase Mediates Formation of Invadopodia through a GTPase-Activating Protein-Independent Function of the RalBP1/RLIP76 Effector by Neel, Nicole F., Rossman, Kent L., Martin, Timothy D., Hayes, Tikvah K., Yeh, Jen Jen, Der, Channing J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Chemokine receptor internalization and intracellular trafficking by Neel, Nicole F., Schutyser, Evemie, Sai, Jiqing, Fan, Guo-Huang, Richmond, Ann

“…The internalization and intracellular trafficking of chemokine receptors have important implications for the cellular responses elicited by chemokine…”
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IQGAP1 is a novel CXCR2-interacting protein and essential component of the "chemosynapse" by Neel, Nicole F, Sai, Jiqing, Ham, Amy-Joan L, Sobolik-Delmaire, Tammy, Mernaugh, Raymond L, Richmond, Ann

“…Chemotaxis is essential for a number of physiological processes including leukocyte recruitment. Chemokines initiate intracellular signaling pathways necessary…”
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Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells by UEDA, Yukiko, NEEL, Nicole F, SCHUTYSER, Evemie, RAMAN, Dayanidhi, RICHMOND, Ann

“…The CXC chemokine receptor 4 (CXCR4) contributes to the metastasis of human breast cancer cells. The CXCR4 COOH-terminal domain (CTD) seems to play a major…”
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RhoB plays an essential role in CXCR2 sorting decisions by Neel, Nicole F, Lapierre, Lynne A, Goldenring, James R, Richmond, Ann

“…The CXCR2 chemokine receptor is a G-protein-coupled receptor that undergoes clathrin-mediated endocytosis upon ligand binding. The trafficking of CXCR2 is…”
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Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression by Hayes, Tikvah K., Neel, Nicole F., Hu, Chaoxin, Gautam, Prson, Chenard, Melissa, Long, Brian, Aziz, Meraj, Kassner, Michelle, Bryant, Kirsten L., Pierobon, Mariaelena, Marayati, Raoud, Kher, Swapnil, George, Samuel D., Xu, Mai, Wang-Gillam, Andrea, Samatar, Ahmed A., Maitra, Anirban, Wennerberg, Krister, Petricoin, Emanuel F., Yin, Hongwei H., Nelkin, Barry, Cox, Adrienne D., Yeh, Jen Jen, Der, Channing J.

“…Induction of compensatory mechanisms and ERK reactivation has limited the effectiveness of Raf and MEK inhibitors in RAS-mutant cancers. We determined that…”
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Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer by RHODES, Lyndsay V, SHORT, Sarah P, FONSECA, Juan P, BRATTON, Melyssa R, SEGAR, Chris, TILGHMAN, Syreeta L, SOBOLIK-DELMAIRE, Tammy, HORTON, Linda W, ZAJA-MILATOVIC, Snjezana, COLLINS-BUROW, Bridgette M, WADSWORTH, Scott, BECKMAN, Barbara S, NEEL, Nicole F, WOOD, Charles E, FUQUA, Suzanne A, NEPHEW, Kenneth P, DENT, Paul, WORTHYLAKE, Rebecca A, CURIEL, Tyler J, HUNG, Mien-Chie, RICHMOND, Ann, BUROW, Matthew E, SALVO, Virgilio A, YUN ZHU, ELLIOTT, Steven, YONGKUN WEI, DIHUA YU, MENGHONG SUN, MUIR, Shannon E

“…Estrogen independence and progression to a metastatic phenotype are hallmarks of therapeutic resistance and mortality in breast cancer patients. Metastasis has…”
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Short tail with skin lesion phenotype occurs in transgenic mice with keratin-14 promoter-directed expression of mutant CXCR2 by Yu, Yingchun, Su, Yingjun, Opalenik, Susan R., Sobolik‐Delmaire, Tammy, Neel, Nicole F., Zaja‐Milatovic, Snjezana, Short, Sarah T., Sai, Jiqing, Richmond, Ann

“…CXCR2 plays an important role during cutaneous wound healing. Transgenic mice were generated using the keratin‐14 promoter/enhancer to direct expression of…”
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Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation by Neel, Nicole F, Stratford, Jeran K, Shinde, Vaishali, Ecsedy, Jeffrey A, Martin, Timothy D, Der, Channing J, Yeh, Jen Jen

“…The high prevalence of KRAS mutations and importance of the RalGEF-Ral pathway downstream of activated K-ras in pancreatic ductal adenocarcinoma (PDAC)…”
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VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis by Neel, Nicole F, Barzik, Melanie, Raman, Dayanidhi, Sobolik-Delmaire, Tammy, Sai, Jiqing, Ham, Amy J, Mernaugh, Raymond L, Gertler, Frank B, Richmond, Ann

“…Chemotaxis regulates the recruitment of leukocytes, which is integral for a number of biological processes and is mediated through the interaction of…”
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The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery by Neel, Nicole F, Martin, Timothy D, Stratford, Jeran K, Zand, Tanya P, Reiner, David J, Der, Channing J

“…The high frequency of RAS mutations in human cancers (33%) has stimulated intense interest in the development of anti-Ras inhibitors for cancer therapy…”
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Characterization of chemokine receptor CXCR2 interacting proteins using a proteomics approach to define the CXCR2 "chemosynapse" by Raman, Dayanidhi, Neel, Nicole F, Sai, Jiqing, Mernaugh, Raymond L, Ham, Amy-Joan L, Richmond, Ann J

“…Chemokine-receptor signaling is initiated upon ligand binding to the receptor and continues through the process of endocytic trafficking by the association of…”
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Absence of interleukin-3 does not affect the severity of local and systemic anaphylaxis but does enhance eosinophil infiltration in a mouse model of allergic peritonitis by Neel, Nicole F., Creasy, Blaine M., Rankin, Jennifer N., Pierce, Elizabeth M., McCoy, Margaret E., Daner, Rebecca H., Fowler, Jessica A., Daniel, Janet C., Lantz, Chris S.

“…Interleukin-3 (IL-3), which is derived from T cells and other sources, can promote the differentiation, proliferation, and migration of mast cells, basophils,…”
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Abstract C15: Therapeutic benefit of targeting ERK in mutant KRAS in pancreatic ductal adenocarcinoma (PDAC) by Hayes, Tikvah K., Neel, Nicole F., Chenard, Melissa, Yeh, Jen Jen, Samatar, Ahmed, Der, Channing J.

“…Abstract The limited success of anti-MEK and anti-RAF therapies with KRAS mutant cancers has been attributed, in part, to de novo or acquired resistance…”
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Abstract C188: RalA phosphorylation as a biomarker in pancreatic ductal adenocarcinoma for Aurora A kinase inhibition in response to the investigational agent MLN8237 by Neel, Nicole F., Escedy, Jeffrey A., Shinde, Vaishali, Der, Channing J., Yeh, Jen Jen

“…Abstract The frequent mutational activation of KRAS in pancreatic ductal adenocarcinoma (PDAC) (greater than 90%) and critical importance of K-Ras-driven…”
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