Search Results - "Neefjes, Jacques J"

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export by van den Boomen, Dick J. H., Sienkiewicz, Agata, Berlin, Ilana, Jongsma, Marlieke L. M., van Elsland, Daphne M., Luzio, J. Paul, Neefjes, Jacques J. C., Lehner, Paul J.

“…Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol…”
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Anthracyclines: biosynthesis, engineering and clinical applications by Hulst, Mandy B, Grocholski, Thadee, Neefjes, Jacques J C, van Wezel, Gilles P, Metsä-Ketelä, Mikko

“…Covering: January 1995 to June 2021Anthracyclines are glycosylated microbial natural products that harbour potent antiproliferative activities. Doxorubicin has…”
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Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy by Reits, Eric A, Hodge, James W, Herberts, Carla A, Groothuis, Tom A, Chakraborty, Mala, Wansley, Elizabeth K, Camphausen, Kevin, Luiten, Rosalie M, de Ru, Arnold H, Neijssen, Joost, Griekspoor, Alexander, Mesman, Elly, Verreck, Frank A, Spits, Hergen, Schlom, Jeffrey, van Veelen, Peter, Neefjes, Jacques J

“…Radiotherapy is one of the most successful cancer therapies. Here the effect of irradiation on antigen presentation by MHC class I molecules was studied. Cell…”
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Synthetic (N,N‑Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs by Wander, Dennis P. A, van der Zanden, Sabina Y, Vriends, Merijn B. L, van Veen, Branca C, Vlaming, Joey G. C, Bruyning, Thomas, Hansen, Thomas, van der Marel, Gijsbert A, Overkleeft, Herman S, Neefjes, Jacques J. C, Codée, Jeroen D. C

“…Anthracyclines are effective drugs in the treatment of various cancers, but their use comes with severe side effects. The archetypal anthracycline drug,…”
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Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules by Berkers, Celia R, de Jong, Annemieke, Schuurman, Karianne G, Linnemann, Carsten, Meiring, Hugo D, Janssen, Lennert, Neefjes, Jacques J, Schumacher, Ton N M, Rodenko, Boris, Ovaa, Huib

“…Peptide splicing, in which two distant parts of a protein are excised and then ligated to form a novel peptide, can generate unique MHC class I-restricted…”
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Immunoproteasome Inhibitor–Doxorubicin Conjugates Target Multiple Myeloma Cells and Release Doxorubicin upon Low-Dose Photon Irradiation by Maurits, Elmer, van de Graaff, Michel J, Maiorana, Santina, Wander, Dennis P. A, Dekker, Patrick M, van der Zanden, Sabina Y, Florea, Bogdan I, Neefjes, Jacques J. C, Overkleeft, Herman S, van Kasteren, Sander I

“…Proteasome inhibitors are established therapeutic agents for the treatment of hematological cancers, as are anthra­cyclines such as doxorubicin. We here…”
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From fixed to FRAP: measuring protein mobility and activity in living cells by Reits, Eric A.J, Neefjes, Jacques J

“…Experiments with fluorescence recovery after photobleaching (FRAP) started 30 years ago to visualize the lateral mobility and dynamics of fluorescent proteins…”
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A brief report on combination chemotherapy and anti–programmed death (ligand) 1 treatment in small-cell lung cancer: Did we choose the optimal chemotherapy backbone? by Mankor, Joanne M., Zwierenga, Fenneke, Dumoulin, Daphne W., Neefjes, Jacques J.C., Aerts, Joachim G.J.V.

“…Extensive-stage small-cell lung cancer (ES-SCLC) is an aggressive cancer that remains very hard to treat. The life expectancy of a patient diagnosed with this…”
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Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N -dimethylated anthracyclines by Hulst, Mandy B, Zhang, Le, van der Heul, Helga U, Du, Chao, Elsayed, Somayah S, Koroleva, Arina, Grocholski, Thadee, Wander, Dennis P A, Metsä-Ketelä, Mikko, Neefjes, Jacques J C, van Wezel, Gilles P

“…Daunorubicin and doxorubicin, two anthracycline polyketides produced by , are potent anticancer agents that are widely used in chemotherapy, despite severe…”
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Interleukin-10 Down-Regulates MHC Class II αβ Peptide Complexes at the Plasma Membrane of Monocytes by Affecting Arrival and Recycling by Koppelman, Bruce, Neefjes, Jacques J, de Vries, Jan E, de Waal Malefyt, René

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Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm by Ono, Nobuhito, Van der Heijden, Ingrid, Scheffer, George L, Van de Wetering, Koen, Van Deemter, Elizabeth, De Haas, Marcel, Boerke, Arjan, Gadella, Bart M, De Rooij, Dirk G, Neefjes, Jacques J, Groothuis, Tom A M, Oomen, Lauran, Brocks, Lenny, Ishikawa, Toshihisa, Borst, Piet

“…The human and murine genes for MRP9 (multidrug resistance-associated protein 9; ABCC12) yield many alternatively spliced RNAs. Using a panel of monoclonal…”
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Selective and ATP-Dependent Translocation of Peptides by the MHC-Encoded Transporter by Neefjes, Jacques J., Momburg, Frank, Hämmerling, Günter J.

“…Major histocompatibility complex (MHC) class I molecules present peptides derived from nuclear and cytosolic proteins to CD8$^+$ T cells. These peptides are…”
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Novel N,N-Dimethyl-idarubicin Analogues Are Effective Cytotoxic Agents for ABCB1-Overexpressing, Doxorubicin-Resistant Cells by van Gelder, Merle A., Li, Yufeng, Wander, Dennis P. A., Berlin, Ilana, Overkleeft, Hermen S., van der Zanden, Sabina Y., Neefjes, Jacques J. C.

“…Anthracyclines comprise one of the most effective anticancer drug classes. Doxorubicin, daunorubicin, epirubicin, and idarubicin have been in clinical use for…”
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Association between Salmonella infection and colon cancer: a nationwide registry-based cohort study by Duijster, Janneke W., Hansen, Jørgen V., Franz, Eelco, Neefjes, Jacques J. C., Frisch, Morten, Mughini-Gras, Lapo, Ethelberg, Steen

“…Laboratory data increasingly suggest that Salmonella infection may contribute to colon cancer (CC) development. Here, we examined epidemiologically the…”
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Re-Exploring the Anthracycline Chemical Space for Better Anti-Cancer Compounds by van Gelder, Merle A., van der Zanden, Sabina Y., Vriends, Merijn B. L., Wagensveld, Roos A., van der Marel, Gijsbert A., Codée, Jeroen D. C., Overkleeft, Herman S., Wander, Dennis P. A., Neefjes, Jacques J. C.

“…The anthracycline anti-cancer drugs are intensely used in the clinic to treat a wide variety of cancers. They generate DNA double strand breaks, but recently…”
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Occupational risk of salmonellosis and campylobacteriosis: a nationwide population-based registry study by Duijster, Janneke W, Franz, Eelco, Neefjes, Jacques J C, Mughini-Gras, Lapo

“…ObjectivesOccupational exposure to animals and foods thereof is a poorly characterised risk factor for salmonellosis and campylobacteriosis, the main causes of…”
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Selectivity of MHC-encoded peptide transporters from human, mouse and rat by Momburg, Frank, Roelse, Joost, Howard, Jonathan C, Butcher, Geoffrey W, Hämmerling, Günter J, Neefjes, Jacques J

“…Major histocompatibility complex (MHC) class I molecules present peptides from degraded intracellular antigens to CD8+ T cells. These peptides are translocated…”
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Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments by Peters, Peter J, Neefjes, Jacques J, Oorschot, Viola, Ploegh, Hidde L, Geuze, Hans J

“…Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules…”
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The identification of the anthracycline aclarubicin as an effective cytotoxic agent for pancreatic cancer by Brouwer, Thomas P., van der Zanden, Sabina Y., van der Ploeg, Manon, van Eendenburg, Jaap D.H., Bonsing, Bert A., de Miranda, Noel F.C.C., Neefjes, Jacques J., Vahrmeijer, Alexander L.

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer, mainly due to its delayed diagnosis and lack of effective therapeutic…”
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A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates by Hislop, Andrew D, Ressing, Maaike E, van Leeuwen, Daphne, Pudney, Victoria A, Horst, Daniëlle, Koppers-Lalic, Danijela, Croft, Nathan P, Neefjes, Jacques J, Rickinson, Alan B, Wiertz, Emmanuel J H J

“…gamma 1-Herpesviruses such as Epstein-Barr virus (EBV) have a unique ability to amplify virus loads in vivo through latent growth-transforming infection…”
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