Search Results - "Neef, Daniel W"

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases by Neef, Daniel W., Jaeger, Alex M., Thiele, Dennis J.

“…Key Points For neurodegenerative diseases such as Huntington's disease, spinocerebellar muscular atrophy, amyotrophic lateral sclerosis, Parkinson's disease…”
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A Direct Regulatory Interaction between Chaperonin TRiC and Stress-Responsive Transcription Factor HSF1 by Neef, Daniel W., Jaeger, Alex M., Gomez-Pastor, Rocio, Willmund, Felix, Frydman, Judith, Thiele, Dennis J.

“…Heat shock transcription factor 1 (HSF1) is an evolutionarily conserved transcription factor that protects cells from protein-misfolding-induced stress and…”
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Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease by Gomez-Pastor, Rocio, Burchfiel, Eileen T., Neef, Daniel W., Jaeger, Alex M., Cabiscol, Elisa, McKinstry, Spencer U., Doss, Argenia, Aballay, Alejandro, Lo, Donald C., Akimov, Sergey S., Ross, Christopher A., Eroglu, Cagla, Thiele, Dennis J.

“…Huntington’s Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death…”
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Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease by Neef, Daniel W, Turski, Michelle L, Thiele, Dennis J

“…Neurodegenerative diseases such as Huntington disease are devastating disorders with no therapeutic approaches to ameliorate the underlying protein misfolding…”
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A stress regulatory network for co‐ordinated activation of proteasome expression mediated by yeast heat shock transcription factor by Hahn, Ji‐Sook, Neef , Daniel W., Thiele, Dennis J.

“…Summary Heat shock transcription factor (HSF) mediates the transcriptional response of eukaryotic cells to heat, infection and inflammation, pharmacological…”
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Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast by Batista-Nascimento, Liliana, Neef, Daniel W, Liu, Phillip C C, Rodrigues-Pousada, Claudina, Thiele, Dennis J

“…Heat shock transcription factor 1 (HSF1) plays an important role in the cellular response to proteotoxic stresses. Under normal growth conditions HSF1 is…”
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Genetic selection for constitutively trimerized human HSF1 mutants identifies a role for coiled-coil motifs in DNA binding by Neef, Daniel W, Jaeger, Alex M, Thiele, Dennis J

“…Human heat shock transcription factor 1 (HSF1) promotes the expression of stress-responsive genes and is a critical factor for the cellular protective response…”
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Polyphosphate Loss Promotes SNF/SWI- and Gcn5-Dependent Mitotic Induction of PHO5 by Neef, Daniel W., Kladde, Michael P.

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Coupling Phosphate Homeostasis to Cell Cycle-Specific Transcription: Mitotic Activation of Saccharomyces cerevisiae PHO5 by Mcm1 and Forkhead Proteins by Pondugula, Santhi, Neef, Daniel W., Voth, Warren P., Darst, Russell P., Dhasarathy, Archana, Reynolds, M. Megan, Takahata, Shinya, Stillman, David J., Kladde, Michael P.

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Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae by Neef, Daniel W., Thiele, Dennis J.

“…Summary In mammalian and Drosophila cells, heat stress strongly reduces general protein translation while activating cap‐independent translation mechanisms to…”
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Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases by Neef, Daniel W, Jaeger, Alex M, Thiele, Dennis J

“…Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and prion-based…”
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Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease: e1000291 by Neef, Daniel W, Turski, Michelle L, Thiele, Dennis J

“…Neurodegenerative diseases such as Huntington disease are devastating disorders with no therapeutic approaches to ameliorate the underlying protein misfolding…”
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