Search Results - "Needham, Maurice R C"

Structure of IL-17A in Complex with a Potent, Fully Human Neutralizing Antibody by Gerhardt, Stefan, Abbott, W. Mark, Hargreaves, David, Pauptit, Richard A., Davies, Rick A., Needham, Maurice R.C., Langham, Caroline, Barker, Wendy, Aziz, Azad, Snow, Melanie J., Dawson, Sarah, Welsh, Fraser, Wilkinson, Trevor, Vaugan, Tris, Beste, Gerald, Bishop, Sarah, Popovic, Bojana, Rees, Gareth, Sleeman, Matthew, Tuske, Steven J., Coales, Stephen J., Hamuro, Yoshitomo, Russell, Caroline

“…IL-17A is a pro-inflammatory cytokine produced by the newly identified Th17 subset of T-cells. We have isolated a human monoclonal antibody to IL-17A…”
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Ligands for retinoic acid receptors are elevated in osteoarthritis and may contribute to pathologic processes in the osteoarthritic joint by Davies, Mark R., Ribeiro, Lyn Rosenbrier, Downey‐Jones, Mark, Needham, Maurice R. C., Oakley, Caroline, Wardale, John

“…Objective Vitamin A derivatives, including all‐trans‐retinoic acid (ATRA), have a well‐established role during skeletal development and limb formation and have…”
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Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts by Davies, Mark R, Harding, Christine J, Raines, Stephanie, Tolley, Kurt, Parker, Andrew E, Downey-Jones, Mark, Needham, Maurice R C

“…Nurr1 is an orphan member of the nuclear receptor superfamily; these orphan receptors are a group for which a ligand has yet to be identified. Nurr1 has been…”
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Identification of in Vitro Folding Conditions for Procathepsin S and Cathepsin S Using Fractional Factorial Screens by Tobbell, Dominique A, Middleton, Brian J, Raines, Stephanie, Needham, Maurice R.C, Taylor, Ian W.F, Beveridge, John Y, Abbott, W.Mark

“…Human procathepsin S and cathepsin S were expressed as inclusion bodies in Escherichia coli. Following solubilization of the inclusion body proteins,…”
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A dominant negative form of IKK2 prevents suppression of apoptosis by the peroxisome proliferate nafenopin by Cosulich, Sabina C, James, Neil H, Needham, Maurice R C, Newham, Peter P

“…Peroxisome proliferators (PPs) are a class of non-genotoxic chemicals that cause rodent liver enlargement and hepatocarcinogenesis. In primary rat hepatocyte…”
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A dominant negative form of IKK2 prevents suppression of apoptosis by the peroxisome proliferator nafenopin by Cosulich, Sabina C., James, Neil H., Needham, Maurice R.C., Newham, Peter P., Bundell, Ken R., Roberts, Ruth A.

“…Peroxisome proliferators (PPs) are a class of non-genotoxic chemicals that cause rodent liver enlargement and hepatocarcinogenesis. In primary rat hepatocyte…”
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Expression and purification of biologically active IGF-binding proteins using the LCR/Mel expression system by Bagnall, Wendy, Sharpe, Paul M, Newham, Peter, Tart, Johnathan, Mott, Richard A, Torr, Vanessa R, Forder, Robert A, Needham, Maurice R.C

“…The anabolic effects and bioavailability of insulin-like growth factors I and II (IGF-I, IGF-II) are regulated in part by a family of IGF-binding proteins…”
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