Search Results - "Needham, Elise J"

Illuminating the dark phosphoproteome by Needham, Elise J, Parker, Benjamin L, Burykin, Timur, James, David E, Humphrey, Sean J

“…Protein phosphorylation is a major regulator of protein function and biological outcomes. This was first recognized through functional biochemical experiments,…”
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Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway by Mills, Richard J., Parker, Benjamin L., Quaife-Ryan, Gregory A., Voges, Holly K., Needham, Elise J., Bornot, Aurelie, Ding, Mei, Andersson, Henrik, Polla, Magnus, Elliott, David A., Drowley, Lauren, Clausen, Maryam, Plowright, Alleyn T., Barrett, Ian P., Wang, Qing-Dong, James, David E., Porrello, Enzo R., Hudson, James E.

“…We have previously developed a high-throughput bioengineered human cardiac organoid (hCO) platform, which provides functional contractile tissue with…”
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Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest by Mills, Richard J., Titmarsh, Drew M., Koenig, Xaver, Parker, Benjamin L., Ryall, James G., Quaife-Ryan, Gregory A., Voges, Holly K., Hodson, Mark P., Ferguson, Charles, Drowley, Lauren, Plowright, Alleyn T., Needham, Elise J., Wang, Qing-Dong, Gregorevic, Paul, Xin, Mei, Thomas, Walter G., Parton, Robert G., Nielsen, Lars K., Launikonis, Bradley S., James, David E., Elliott, David A., Porrello, Enzo R., Hudson, James E.

“…The mammalian heart undergoes maturation during postnatal life to meet the increased functional requirements of an adult. However, the key drivers of this…”
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Personalized phosphoproteomics identifies functional signaling by Needham, Elise J., Hingst, Janne R., Parker, Benjamin L., Morrison, Kaitlin R., Yang, Guang, Onslev, Johan, Kristensen, Jonas M., Højlund, Kurt, Ling, Naomi X. Y., Oakhill, Jonathan S., Richter, Erik A., Kiens, Bente, Petersen, Janni, Pehmøller, Christian, James, David E., Wojtaszewski, Jørgen F. P., Humphrey, Sean J.

“…Protein phosphorylation dynamically integrates environmental and cellular information to control biological processes. Identifying functional phosphorylation…”
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Development of a human skeletal micro muscle platform with pacing capabilities by Mills, Richard J., Parker, Benjamin L., Monnot, Pauline, Needham, Elise.J, Vivien, Celine J., Ferguson, Charles, Parton, Robert G., James, David E., Porrello, Enzo R., Hudson, James E.

“…Three dimensional engineered culture systems are powerful tools to rapidly expand our knowledge of human biology and identify novel therapeutic targets for…”
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The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms by Pham, Tang Cam Phung, Raun, Steffen Henning, Havula, Essi, Henriquez-Olguín, Carlos, Rubalcava-Gracia, Diana, Frank, Emma, Fritzen, Andreas Mæchel, Jannig, Paulo R., Andersen, Nicoline Resen, Kruse, Rikke, Ali, Mona Sadek, Irazoki, Andrea, Halling, Jens Frey, Ringholm, Stine, Needham, Elise J., Hansen, Solvejg, Lemminger, Anders Krogh, Schjerling, Peter, Petersen, Maria Houborg, de Almeida, Martin Eisemann, Jensen, Thomas Elbenhardt, Kiens, Bente, Hostrup, Morten, Larsen, Steen, Ørtenblad, Niels, Højlund, Kurt, Kjær, Michael, Ruas, Jorge L., Trifunovic, Aleksandra, Wojtaszewski, Jørgen Frank Pind, Nielsen, Joachim, Qvortrup, Klaus, Pilegaard, Henriette, Richter, Erik Arne, Sylow, Lykke

“…Decline in mitochondrial function is linked to decreased muscle mass and strength in conditions like sarcopenia and type 2 diabetes. Despite therapeutic…”
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Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance by Fazakerley, Daniel J., van Gerwen, Julian, Cooke, Kristen C., Duan, Xiaowen, Needham, Elise J., Díaz-Vegas, Alexis, Madsen, Søren, Norris, Dougall M., Shun-Shion, Amber S., Krycer, James R., Burchfield, James G., Yang, Pengyi, Wade, Mark R., Brozinick, Joseph T., James, David E., Humphrey, Sean J.

“…The failure of metabolic tissues to appropriately respond to insulin (“insulin resistance”) is an early marker in the pathogenesis of type 2 diabetes. Protein…”
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Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion by Needham, Elise J., Humphrey, Sean J., Cooke, Kristen C., Fazakerley, Daniel J., Duan, Xiaowen, Parker, Benjamin L., James, David E.

“…Exercise engages signaling networks to control the release of circulating factors beneficial to health. However, the nature of these networks remains…”
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Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells by Recasens, Ariadna, Humphrey, Sean J., Ellis, Michael, Hoque, Monira, Abbassi, Ramzi H., Chen, Brianna, Longworth, Mitchell, Needham, Elise J., James, David E., Johns, Terrance G., Day, Bryan W., Kassiou, Michael, Yang, Pengyi, Munoz, Lenka

“…Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we…”
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Accessible interview practices for disabled scientists and engineers by Greene, Samuel M., Schachat, Sandra R., Arita-Merino, Naomi, Cao, Xiangkun Elvis, Gurnani, Harsha, Heyns, Michael, Cagigas, Maria L., Maikawa, Caitlin L., Needham, Elise J., Perets, Ethan A., Phillips, Elizabeth, Waddle, Anthony W., Wilkinson, Christine E., Zhou, Kevin C., Zlotnick, Hannah M.

“…Increasing representation of people with disabilities in science and engineering will require systemic changes to the culture around support and…”
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Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet by Yau, Belinda, Naghiloo, Sheyda, Diaz-Vegas, Alexis, Carr, Austin V., Van Gerwen, Julian, Needham, Elise J., Jevon, Dillon, Chen, Sing-Young, Hoehn, Kyle L., Brandon, Amanda E., Macia, Laurence, Cooney, Gregory J., Shortreed, Michael R., Smith, Lloyd M., Keller, Mark P., Thorn, Peter, Larance, Mark, James, David E., Humphrey, Sean J., Kebede, Melkam A.

“…Pancreatic islets are essential for maintaining physiological blood glucose levels, and declining islet function is a hallmark of type 2 diabetes. We employ…”
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Motifs mapped for almost all human kinase enzymes by Humphrey, Sean J, Needham, Elise J

“…Advances in our ability to identify and quantify phosphorylation using mass spectrometry has led to a rapid rise in the number of known phosphorylation sites…”
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Targets mapped for almost all human kinase enzymes by Humphrey, Sean J., Needham, Elise J.

“…A computational resource can identify candidate protein targets for almost all members of a major class of kinase enzyme in humans, with implications for…”
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An integrative systems genetic analysis of mammalian lipid metabolism by Parker, Benjamin L., Calkin, Anna C., Seldin, Marcus M., Keating, Michael F., Tarling, Elizabeth J., Yang, Pengyi, Moody, Sarah C., Liu, Yingying, Zerenturk, Eser J., Needham, Elise J., Miller, Matthew L., Clifford, Bethan L., Morand, Pauline, Watt, Matthew J., Meex, Ruth C. R., Peng, Kang-Yu, Lee, Richard, Jayawardana, Kaushala, Pan, Calvin, Mellett, Natalie A., Weir, Jacquelyn M., Lazarus, Ross, Lusis, Aldons J., Meikle, Peter J., James, David E., de Aguiar Vallim, Thomas Q., Drew, Brian G.

“…Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and progression of hepatosteatosis and metabolic syndrome. These conditions are…”
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Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry by Nelson, Marin E, Parker, Benjamin L, Burchfield, James G, Hoffman, Nolan J, Needham, Elise J, Cooke, Kristen C, Naim, Timur, Sylow, Lykke, Ling, Naomi XY, Francis, Deanne, Norris, Dougall M, Chaudhuri, Rima, Oakhill, Jonathan S, Richter, Erik A, Lynch, Gordon S, Stöckli, Jacqueline, James, David E

“…Exercise stimulates cellular and physiological adaptations that are associated with widespread health benefits. To uncover conserved protein phosphorylation…”
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Vascular cells improve functionality of human cardiac organoids by Voges, Holly K., Foster, Simon R., Reynolds, Liam, Parker, Benjamin L., Devilée, Lynn, Quaife-Ryan, Gregory A., Fortuna, Patrick R.J., Mathieson, Ellen, Fitzsimmons, Rebecca, Lor, Mary, Batho, Christopher, Reid, Janice, Pocock, Mark, Friedman, Clayton E., Mizikovsky, Dalia, Francois, Mathias, Palpant, Nathan J., Needham, Elise J., Peralta, Marina, Monte-Nieto, Gonzalo del, Jones, Lynelle K., Smyth, Ian M., Mehdiabadi, Neda R., Bolk, Francesca, Janbandhu, Vaibhao, Yao, Ernestene, Harvey, Richard P., Chong, James J.H., Elliott, David A., Stanley, Edouard G., Wiszniak, Sophie, Schwarz, Quenten, James, David E., Mills, Richard J., Porrello, Enzo R., Hudson, James E.

“…Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular cells within human cardiac organoids (hCOs) enhance their…”
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Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets by Zhao, Jing Hua, Stacey, David, Eriksson, Niclas, Macdonald-Dunlop, Erin, Hedman, Åsa K., Kalnapenkis, Anette, Enroth, Stefan, Cozzetto, Domenico, Digby-Bell, Jonathan, Marten, Jonathan, Folkersen, Lasse, Herder, Christian, Jonsson, Lina, Bergen, Sarah E., Gieger, Christian, Needham, Elise J., Surendran, Praveen, Paul, Dirk S., Polasek, Ozren, Thorand, Barbara, Grallert, Harald, Roden, Michael, Võsa, Urmo, Esko, Tonu, Hayward, Caroline, Johansson, Åsa, Gyllensten, Ulf, Powell, Nick, Hansson, Oskar, Mattsson-Carlgren, Niklas, Joshi, Peter K., Danesh, John, Padyukov, Leonid, Klareskog, Lars, Landén, Mikael, Wilson, James F., Siegbahn, Agneta, Wallentin, Lars, Mälarstig, Anders, Butterworth, Adam S., Peters, James E.

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Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry by Nelson, Marin E, Parker, Benjamin L, Burchfield, James G, Hoffman, Nolan J, Needham, Elise J, Cooke, Kristen C, Naim, Timur, Sylow, Lykke, Ling, Naomi XY, Francis, Deanne, Norris, Dougall M, Chaudhuri, Rima, Oakhill, Jonathan S, Richter, Erik A, Lynch, Gordon S, Stöckli, Jacqueline, James, David E

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Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment by Rudraraju, Rajeev, Gartner, Matthew J., Neil, Jessica A., Stout, Elizabeth S., Chen, Joseph, Needham, Elise J., See, Michael, Mackenzie-Kludas, Charley, Yang Lee, Leo Yi, Wang, Mingyang, Pointer, Hayley, Karavendzas, Kathy, Abu-Bonsrah, Dad, Drew, Damien, Yang Sun, Yu Bo, Tan, Jia Ping, Sun, Guizhi, Salavaty, Abbas, Charitakis, Natalie, Nim, Hieu T., Currie, Peter D., Tham, Wai-Hong, Porrello, Enzo, Polo, Jose M., Humphrey, Sean J., Ramialison, Mirana, Elliott, David A., Subbarao, Kanta

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily infects the respiratory tract, but pulmonary and cardiac complications occur in severe…”
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Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise by Kristensen, Jonas M, Kjøbsted, Rasmus, Larsen, Trine J, Carl, Christian S, Hingst, Janne R, Onslev, Johan, Birk, Jesper B, Thorup, Anette, Steenberg, Dorte E, Knudsen, Jonas R, Henriksen, Nicolai S, Needham, Elise J, Halling, Jens F, Gudiksen, Anders, Rundsten, Carsten F, Hanghøj, Kristian E, Stinson, Sara E, Hoier, Birgitte, Hansen, Camilla C, Jensen, Thomas E, Hellsten, Ylva, Pilegaard, Henriette, Grarup, Niels, Olesen, Jesper, Humphrey, Sean J, James, David E, Pedersen, Michael L, Richter, Erik A, Hansen, Torben, Jørgensen, Marit E, Wojtaszewski, Jørgen F P

“…In the Greenlandic Inuit population, 4% are homozygous carriers of a genetic nonsense TBC1D4 p.Arg684Ter variant leading to loss of the muscle-specific isoform…”
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