Search Results - "Needell, James C"

The Role of the Intestinal Microbiome in Type 1 Diabetes Pathogenesis by Needell, James C., Zipris, Danny

“…The gastrointestinal system represents one of the largest interfaces between the human internal microenvironment and the external world. This system harbors…”
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Disulfide disruption reverses mucus dysfunction in allergic airway disease by Morgan, Leslie E., Jaramillo, Ana M., Shenoy, Siddharth K., Raclawska, Dorota, Emezienna, Nkechinyere A., Richardson, Vanessa L., Hara, Naoko, Harder, Anna Q., NeeDell, James C., Hennessy, Corinne E., El-Batal, Hassan M., Magin, Chelsea M., Grove Villalon, Diane E., Duncan, Gregg, Hanes, Justin S., Suk, Jung Soo, Thornton, David J., Holguin, Fernando, Janssen, William J., Thelin, William R., Evans, Christopher M.

“…Airway mucus is essential for lung defense, but excessive mucus in asthma obstructs airflow, leading to severe and potentially fatal outcomes. Current asthma…”
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Maternal treatment with short-chain fatty acids modulates the intestinal microbiota and immunity and ameliorates type 1 diabetes in the offspring by Needell, James C, Ir, Diana, Robertson, Charles E, Kroehl, Miranda E, Frank, Daniel N, Zipris, Danny

“…We recently hypothesized that the intestinal microbiota and the innate immune system play key roles in the mechanism of Kilham Rat Virus-induced type 1…”
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Involvement of adipose tissue inflammation and dysfunction in virus-induced type 1 diabetes by Needell, James C, Brown, Madalyn N, Zipris, Danny

“…The etiopathogenesis of type 1 diabetes (T1D) remains poorly understood. We used the LEW1.WR1 rat model of Kilham rat virus (KRV)-induced T1D to better…”
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Implication of the intestinal microbiome as a potential surrogate marker of immune responsiveness to experimental therapies in autoimmune diabetes by Needell, James C, Dinarello, Charles A, Ir, Diana, Robertson, Charles E, Ryan, Sarah M, Kroehl, Miranda E, Frank, Daniel N, Zipris, Danny

“…Type 1 diabetes (T1D) is an autoimmune proinflammatory disease with no effective intervention. A major obstacle in developing new immunotherapies for T1D is…”
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Rat Models of Virus-Induced Type 1 Diabetes by Needell, James C, Zipris, Danny

“…Studies performed in humans and animal models have implicated the environment in the etiology of type 1 diabetes (T1D), but the nature and timing of the…”
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Targeting Innate Immunity for Type 1 Diabetes Prevention by Needell, James C., Zipris, Danny

“…Purpose of Review Despite immense research efforts, type 1 diabetes (T1D) remains an autoimmune disease without a known trigger or approved intervention. Over…”
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